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Micronutrient supplementation: when is best and why?*

Published online by Cambridge University Press:  05 March 2007

Mary R. L'abbé ,
Kevin A. Cockell  and
Nora S. Lee
Mary R. L'abbé*
Affiliation:
Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ONK1A OL2, Canada
Kevin A. Cockell
Affiliation:
Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ONK1A OL2, Canada
Nora S. Lee
Affiliation:
Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ONK1A OL2, Canada
*
†Corresponding author: Dr Mary R. L'Abbe, fax +1 613941 6182, mary_l'[email protected]
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Abstract

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For many nutrients, a systematic determination of the effects of high intakes over extended periods of time has not been conducted. Governments and scientific bodies have just begun to establish the methodology for, and to conduct, nutrient risk assessments for setting ‘tolerable upper levels of intake’ (UL) for nutrients. Nutrient risk assessment provides the framework for using available information to evaluate the safety of nutrients when added to foods or when consumed as supplements, in order to minimize the risks from over-consumption. When intakes are inadequate, food fortification may be the appropriate choice for some nutrients, while in other situations, when requirements are markedly higher for some population subgroups than for the general population, supplements may be the most appropriate intervention. The present paper will present some examples of how to use the UL along with food consumption data to assess the appropriateness of food fortification v. supplementation strategies and to assess their impact on nutrient intakes of the population. The important steps to be followed when evaluating which approach is best are: (a) establishing need, i.e. assessing the gap between current and desired intakes; (b) assessing safety, i.e. consider the margin of safety between requirement and UL as well as the severity and reversibility of the adverse effect that was used to establish the UL; (c) estimating exposure through statistical modelling, in which population-based estimates of intakes before and after the intervention are compared; (d) monitoring the impact of the intervention to ensure that the desired benefits are achieved and that excessive intakes are minimized. This approach can optimize the public health benefits of food fortification or supplement use while minimizing the risks due to excessive intakes.

Keywords

Micronutrient intakesNutrient risk assessmentTolerable upper levels of intakeSupplementation v. fortification strategies
Type
Micronutrient Group Symposium on ‘Micronutrient supplementation: when and why?’
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 2 , May 2003 , pp. 413 - 420
Copyright
Copyright © The Nutrition Society 2003

Footnotes

*

Bureau of Nutritional Sciences Publication no.575

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