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Food allergy and nutrition in early life: implications for later health

Published online by Cambridge University Press:  28 February 2007

Ranjit Kumar Chandra
Ranjit Kumar Chandra*
Affiliation:
Memorial University of Newfoundland, Janeway Child Health Centre, St John's, Newfoundland A1A 1R8, Canada
*
*Corresponding author: Dr R. K. Chandra, fax +1 709 778 4191, email [email protected]
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Abstract

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Allergic diseases are a common cause of illness in most industrialized countries. Diet during early childhood is an important determinant of the development of allergy, particularly in high-risk infants who have a parental history of atopy. Maternal avoidance of highly-allergenic foods during pregnancy and lactation, prolonged exclusive breast-feeding, the use of a hydrolysed milk formula, and delayed introduction of dairy products, eggs, fish, nuts and soyabean are associated with a lower incidence of allergic symptoms and signs. These beneficial effects are observed for as long as 18 years of age. Similarly, nutrition and physical growth are important factors that influence immunocompetence and morbidity due to infections. Small-for-gestational age low-birth-weight infants show prolonged impairment of cell-mediated immunity, antibody responses and phagocyte function. Recent studies indicate the beneficial effect of moderate amounts of Zn given in the first 6 months of life. Thus, diet and nutrition in early life are crucial for the development of allergic and infectious disease throughout childhood and into adulthood.

Keywords

Food allergyLow-birth-weight infantsImmune responsesInfection
Type
Symposium on ‘Growing up with good nutrition: a focus on the first two decades’
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 2 , May 2000 , pp. 273 - 277
Copyright
Copyright © The Nutrition Society 2000

References

Arshad, SH, Matthews, S, Grant, C & Hide, DW (1992) Effect of allergen avoidance on development of allergic disorders in infancy. Lancet 339, 1493–1497.Google Scholar
Baumgartner, M, Brown, CA, Exl, B-M, Secretin, M-C, van't Hoft, M & Haschke, F (1998) Controlled trials investigating the use of one partially hydrolyzed whey formula for dietary prevention of atopic manifestations until 60 months of age: An overview using meta-analytic techniques. Nutrition Research 8, 1425–1442.Google Scholar
Burney, PGJ, Chinn, S & Rona, R (1990) Has the prevalence of asthma increased in children? British Medical Journal 300, 1306–1310.Google Scholar
Chandra, RK (1975a) Fetal malnutrition and postnatal immunocompetence. American Journal of Diseases of Children 129, 450–454.Google Scholar
Chandra, RK (1975b) Levels of IgG subclasses, IgM and tetanus antitoxin in paired maternal and foetal sera: Findings in healthy pregnancy and placental insufficiency. In Maternofoetal Transmission of Immunoglobulins, pp. 77–90 [Hemmings, WA, editor]. London: Cambridge University Press.Google Scholar
Chandra, RK (1975c) Antibody formation in first and second generation offspring of nutritionally deprived rats. Science 190, 289–290.Google Scholar
Chandra, RK (1980) Serum thymic hormone activity and cell-mediated immunity in healthy neonates, preterm infants and small-for-gestional age infants. Pediatrics 67, 407–411.Google Scholar
Chandra, RK (1986) Serum levels and synthesis of IgG subclasses in small for gestation low birth weight infants and in patients with selective IgA deficiency. In Immunoglobulins Subclass Deficiencies, pp. 90–99 [Hanson, LA, Soderstrom, T and Oxelius, V-A, editors]. Basel: Kruger.Google Scholar
Chandra, RK (1991) Interactions between early nutrition and the immune system. In The Childhood Environment and Adult Disease. Ciba Foundation Symposium no. 156, pp. 77–88 [Bock, GR and Whelan, J, editors]. Chichester: Wiley-Interscience.Google Scholar
Chandra, RK (1995) Food allergy and atopic disease – Overview. Clinical Reviews in Allergy and Immunology 13, 293–234.Google Scholar
Chandra, RK (1997) Five year follow-up of high risk infants with family history of allergy exclusively breast-fed or fed partial whey hydrolysate, soy and conventional cow's milk formulas. Journal of Pediatiatric Gastroenterology and Nutrition 24, 380–388.Google Scholar
Chandra, RK (2000) Impact of iron and zinc deficiencies on immunity and risk of infection. In Nutrition, Immunity and Infection [Suskind, R, editor]. New York: Raven Press (In the Press).Google Scholar
Chandra, RK, Ali, S, Kutty, KM & Chandra, S (1977) Thymus-dependent lymphocytes and delayed hypersensitivity in low birth weight infants. Biology of the Neonate 31, 15–18.Google Scholar
Chandra, RK & Baker, M (1983) Numerical and functional deficiency of suppressor T cells precedes development of atopic eczema. Lancet ii, 1393–1394.Google Scholar
Chandra, RK, Puri, S, Suraiya, C & Cheema, PS (1986) Influence of maternal food antigen avoidance during pregnancy on incidence of atopic eczema in infants. Clinical Allergy 16, 563–569.Google Scholar
Hattevig, G, Kjellman, B, Sigurs, N & Kjellman, N-I (1989) The effect of maternal avoidance of eggs, cow's milk and fish during lactation upon allergic manifestations in infants. Clinical Allergy 19, 27–32.Google Scholar
Hill, A (2000) Zinc supplements in low birth weight infants. In Nutrition, Immunity and Infection [Suskind, R, editor.] New York: Raven Press (In the Press).Google Scholar
Kleinman, RE, Bahna, S, Powell, GF & Sampson, HA (1991) Use of infant formulas in infants with cow milk allergy. A review and recommendations. Pediatric Allergy and Immunology 2, 146–155.Google Scholar
Lilja, G, Dannaeus, A & Fälth-Magnusson, K (1988) Immune response of the atopic woman and foetus. Effects of high- and low-dose food allergen intake during late pregnancy. Clinical Allergy 18, 131–142.Google Scholar
Moscatelli, P, Bricarelli, FG, Piccinini, A, Tomatis, C & Dufour, MA (1976) Defective immunocompetence in foetal malnutrition. Helvetia Paediatrica Acta 21, 241–247.Google Scholar
Reiger, C, Bauer, CP, Koletzko, B, Lantz, MJ & Reinhardt, D (1998) Ten years of food allergy prevention with partial whey hydrolysate HA formula. Nutrition Research 18, 1327–1462.Google Scholar
Saarinen, UM & Kajosaari, M (1995) Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old. Lancet 346, 1065–1069.Google Scholar
Taylor, B, Wadsworth, J, Wadsworth, M & Peckam, C (1984) Changes in the prevalence of eczema since the 1939–45 war. Lancet ii, 1255–1257.Google Scholar