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Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle

Published online by Cambridge University Press:  05 March 2007

Yun Chau Long ,
Ulrika Widegren  and
Juleen R. Zierath
Yun Chau Long
Affiliation:
Department of Surgical Sciences, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4, II, SE-171 77, Stockholm, Sweden
Ulrika Widegren
Affiliation:
Department of Surgical Sciences, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4, II, SE-171 77, Stockholm, Sweden
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Abstract

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Exercise training improves glucose homeostasis through enhanced insulin sensitivity in skeletal muscle. Muscle contraction through physical exercise is a physiological stimulus that elicits multiple biochemical and biophysical responses and therefore requires an appropriate control network. Mitogen-activated protein kinase (MAPK) signalling pathways constitute a network of phosphorylation cascades that link cellular stress to changes in transcriptional activity. MAPK cascades are divided into four major subfamilies, including extracellular signal-regulated kinases 1 and 2, p38 MAPK, c-Jun NH2-terminal kinase and extracellular signal-regulated kinase 5. The present review will present the current understanding of parallel MAPK signalling in human skeletal muscle in response to exercise and muscle contraction, with an emphasis on identifying potential signalling mechanisms responsible for changes in gene expression.

Keywords

Mitogen-activated protein kinaseSkeletal muscleExercise
Type
Symposium 1: Exercise signalling pathways controlling fuel oxidation during and after exercise
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 2 , May 2004 , pp. 227 - 232
Copyright
Copyright © The Nutrition Society 2004

References

Abe, JI, Kusuhara, M, Ulevitch, RJ, Berk, BC & Lee, JD (1996) Big mitogen-activated protein kinase 1(BMK1) is a redox-sensitive kinase. Journal of Biological Chemistry 271, 16586–16590.CrossRefGoogle ScholarPubMed
Alessi, DR, Cuenda, A, Cohen, P, Dudley, DT & Saltiel, AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. Journal of Biological Chemistry 270, 27489–27494.CrossRefGoogle ScholarPubMed
Aronson, D, Dufresne, SD & Goodyear, LJ (1997a) Contractile activity stimulates the c-Jun NH2-terminal kinase pathway in rat skeletal muscle. Journal of Biological Chemistry 272, 25636–25640.CrossRefGoogle ScholarPubMed
Aronson, D, Violan, MA, Dufresne, SD, Zangen, D, Fielding, RA & Goodyear, LJ (1997b) Exercise stimulates the mitogen-activated protein kinase pathway in human skeletal muscle. Journal of Clinical Investigation 99, 1251–1257.CrossRefGoogle ScholarPubMed
Black, BL & Olson, EN (1998) Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annual Review of Cell Developmental Biology 14, 167–196.Google Scholar
Boppart, MD, Aronson, D, Gibson, L, Roubenoff, R, Abad, LW, Bean, J, Goodyear, LJ & Fielding, RA (1999) Eccentric exercise markedly increases c-Jun NH 2 -terminal kinase activity in human skeletal muscle. Journal of Applied Physiology 87, 1668–1673.Google Scholar
Boppart, MD, Asp, S, Wojtaszewski, JFP, Fielding, RA, Mohr, T & Goodyear, LJ (2000) Marathon running transiently increases c-Jun NH 2 -terminal kinase and p38γ activities in human skeletal muscle. Journal of Physiology (London) 526, 663–669.CrossRefGoogle Scholar
Brunet, A & Pouyssegur, J (1997) Mammalian MAP kinase modules: How to transduce specific signals. Essays in Biochemistry 32, 1–16.Google Scholar
Chen, Z, Gibson, TB, Robinson, F, Silvestro, L, Pearson, G, Xu, B, Wright, A, Vanderbilt, C & Cobb, MH (2001) MAP kinases. Chemical Reviews 101, 2449–2476.CrossRefGoogle ScholarPubMed
Cuenda, A, Rouse, J, Doza, YN, Meier, R, Cohen, P, Gallagher, T-F, Young, PR & Lee, JC (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Letters 364, 229–233.Google Scholar
Deak, M, Clifton, A, Lucocq, L & Alessi, D (1998) Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO Journal 15, 6552–6563.Google Scholar
Goedert, M, Cuenda, A, Craxton, M, Jakes, R & Cohen, P (1997) Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO Journal 16, 3563–3571.Google Scholar
Johnson, GL & Lapadat, R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911–1912.Google Scholar
Krook, A, Widegren, U, Jiang, XJ, Henriksson, J, Wallberg-Henriksson, H, Alessi, D & Zierath, JR (2000) Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle. American Journal of Physiology 279, R1716–R1721.Google Scholar
Nebreda, AR & Gavin, AC (1999) Cell survival demands some Rsk. Science 286, 1309–1310.Google Scholar
Pearson, G, Robinson, F Beers Gibson, T, Xu, BE, Karandikar, M, Berman, K & Cobb, MH (2001) Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocrine Reviews 22, 153–183.Google Scholar
Raught, B & Gingras, AC (1999) eIF4E activity is regulated at multiple levels. International Journal of Biochemistry and Cell Biology 31, 43–57.CrossRefGoogle ScholarPubMed
Ryder, JW, Fahlman, R, Wallberg-Henriksson, H, Alessi, DR, Krook, A & Zierath, JR (2000) Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle: Involvement of the mitogen- and stress-activated protein kinase 1. Journal of Biological Chemistry 275, 1457–1462.Google Scholar
Sassone-Corsi, P, Mizzen, CA, Cheung, P, Crosio, C, Monaco, L, Jacquot, S, Hanauer, A & Allis, CD (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285, 886–891.Google Scholar
Schonwasser, DC, Marais, RM, Marshall, CJ & Parker, PJ (1998) Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Molecular and Cellular Biology 18, 790–798.CrossRefGoogle ScholarPubMed
Thomson, S, Clayton, AL, Hazzalin, CA, Rose, S, Barratt, MJ & Mahadevan, LC (1999a) The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO Journal 18, 4779–4793.Google Scholar
Thomson, S, Mahadevan, LC & Clayton, AL (1999b) MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Seminars in Cell and Developmental Biology 10, 205–214.CrossRefGoogle ScholarPubMed
Van Biesen, T, Hawes, BE, Raymond, JR, Luttrell, LM, Koch, WJ & Lefkowitz, RJ (1996) G(o)-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. Journal of Biological Chemistry 271, 1266–1269.Google Scholar
Widegren, U, Jiang, XJ, Krook, A, Chibalin, AV, Björnholm, M, Tally, M, Roth, RA, Henriksson, J, Wallberg-Henriksson, H & Zierath, JR (1998) Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle. FASEB Journal 12, 1379–1389.Google Scholar
Widegren, U, Ryder, JW & Zierath, JR (2001) Mitogen-activated protein kinase (MAPK) signal transduction in skeletal muscle: Effects of exercise and muscle contraction. Acta Physiologica Scandinavica 172, 227–238.CrossRefGoogle ScholarPubMed
Widegren, U, Wretman, C, Lionikas, A, Westerblad, H & Henriksson, J (2000) Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle. Pflugers Archives European Journal of Physiology 441, 317–322.Google Scholar
Williamson, D, Gallagher, P, Harber, M, Hollon, C & Trappe, S (2003) Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. Journal of Physiology (London) 547, 977–987.Google Scholar
Wretman, C, Lionikas, A, Widegren, U, Lannergren, J, Westerblad, H & Henriksson, J (2001) Effects of concentric and eccentric contractions on phosphorylation of MAPKerk1/2 and MAPKp38 in isolated rat skeletal muscle. Journal of Physiology (London) 535, 155–164.Google Scholar
Wretman, C, Widegren, U, Lionikas, A, Westerblad, H & Henriksson, J (2000) Differential activation of mitogen-activated protein kinase signalling pathways by isometric contractions in isolated slow- and fast-twitch rat skeletal muscle. Acta Physiologica Scandinavica 170, 45–49.CrossRefGoogle ScholarPubMed
Yu, M, Blomstrand, E, Chibalin, AV, Krook, A & Zierath, JR (2001) Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle. Journal of Physiology (London) 536, 273–282.Google Scholar
Yu, M, Stepto, NK, Chibalin, AV, Fryer, LGD, Carling, D, Krook, A, Hawley, JA & Zierath, JR (2003) Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. Journal of Physiology (London) 546, 327–335.Google Scholar
Zetser, A, Gredinger, E & Bengal, E (1999) p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the MEF2c transcription factor. Journal of Biological Chemistry 274, 5193–5200.CrossRefGoogle ScholarPubMed
Zhao, Y, Bjorbaek, C & Moller, DE (1996) Regulation and interaction of pp90(RSK) isoforms with mitogen-activated protein kinase. Journal of Biological Chemistry 271, 29773–29779.CrossRefGoogle Scholar
Zierath, JR (2002) Exercise effects of muscle insulin signaling and action. Exercise training-induced changes in insulin signaling in skeletal muscle. Journal of Applied Physiology 93, 773–781.CrossRefGoogle Scholar
Zierath, JR, Wallberg-Henriksson, H (1992) Exercise training in obese diabetic patients. Sports Medicine 14, 171–189.CrossRefGoogle ScholarPubMed