Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-18T20:53:05.204Z Has data issue: false hasContentIssue false
  • English
  • Français

Early diet and growth: impact on ageing

Published online by Cambridge University Press:  28 February 2007

A. Aihie Sayer*  and
C. Cooper
C. Cooper
Affiliation:
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The modification of ageing by nutritional intervention is well recognised. Post-weaning diet restriction is the only widely reproducible method to slow ageing, but the effects of prenatal and preweaning diet restriction have been less well characterised. There is some evidence that diet restriction instituted in utero or shortly after birth may have an opposite effect and be associated with increased ageing, and recent work suggests that it may shorten lifespan. Interest in this area has been rekindled by the growing body of epidemiological evidence showing that a number of age-related diseases are associated with poor growth and inadequate nutrition in early life. The relevance of this association to structural and functional ageing changes in different systems is now being considered. Work on musculo-skeletal ageing has demonstrated that loss of muscle strength and bone mass is greater in individuals who did not grow well in early life, and a range of studies suggests that maternal, developmental and nutritional factors are important. The underlying mechanisms remain speculative, and it remains to be determined whether they are system-specific or universal throughout the body. A new cohort of subjects aged between 60 and 70 years is being established to investigate how genetic factors interact with growth and nutritional influences to programme musculo-skeletal ageing in later life.

Keywords

AgeingMusculo-skeletal ageingGrowthPrenatal diet restrictionProgramming
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 61 , Issue 1 , February 2002 , pp. 79 - 85
Copyright
Copyright © The Nutrition Society 2002

References

Aihie Sayer, A & Cooper, C (1997) Undernutrition and aging. Gerontology 43, 203–205.CrossRefGoogle ScholarPubMed
Aihie Sayer, A, Cooper, C, Evans, JR, Rauf, A, Wormald, RPL, Osmond, C & Barker, DJP (1998) Are rates of ageing determined in utero? Age and Ageing 27, 579–583.CrossRefGoogle Scholar
Aihie Sayer, A, Dunn, R, Langley-Evans, S & Cooper, C (2001) Prenatal exposure to a maternal low protein diet shortens life span in rats. Gerontology 47, 9–14.CrossRefGoogle ScholarPubMed
Barker, DJP (1998) Mothers, Babies and Health in Later Life. Edinburgh: Churchill Livingstone.Google Scholar
Barker, DJP, Osmond, C, Golding, J, Kuh, D & Wadsworth, MEJ (1989) Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. British Medical Journal 298, 564–567.CrossRefGoogle ScholarPubMed
Brailsford Robertson, T & Ray, LA (1920) On the growth of relatively long lived compared with that of relatively short lived animals. Journal of Biological Chemistry 42, 71–77.Google Scholar
Campbell, DM, Hall, MH, Barker, DJP, Cross, J, Shiell, AW & Godfrey, KM (1996) Diet in pregnancy and the offspring's blood pressure 40 years later. British Journal of Obstetrics and Gynaecology 103, 273–280.Google Scholar
Cefalu, WT, Wagner, JD, Bell-Farrow, AD, Edwards, IJ, Terry, JG, Weindruch, R & Kemnitz, JW (1999) Influence of caloric restriction on the development of atherosclerosis in nonhuman primates: progress to date. Toxicological Science 52, 49–55.Google Scholar
Chow, BF & Lee, C-J (1964) Effect of dietary restriction of pregnant rats on body weight gain of the offspring. Journal of Nutrition 82, 10–18.Google Scholar
Cooper, C, Cawley, M, Bhalla, A, Egger, P, Ring, F, Morton, L & Barker, D (1995) Childhood growth, physical activity, and peak bone mass in women. Journal of Bone and Mineral Research 10, 940–947.CrossRefGoogle ScholarPubMed
Cooper, C, Eriksson, JG, Forsen, T, Osmond, C, Tuomilehto, J & Barker, DJP (2001) Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study. Osteoporosis International 12, 623–629.CrossRefGoogle ScholarPubMed
Cooper, C, Fall, C, Egger, P, Hobbs, R, Eastell, R & Barker, D (1997) Growth in infancy and bone mass in later life. Annals of the Rheumatic Diseases 56, 17–21.CrossRefGoogle ScholarPubMed
Cooper, C, Walker-Bone, K, Arden, N & Dennison, E (2000) Novel insights into the pathogenesis of osteoporosis: the role of intrauterine programming. Rheumatology (Oxford) 39, 1312–1315.CrossRefGoogle ScholarPubMed
Dennison, E, Godfrey, K, Wheeler, T, Taylor, S, Kellingray, S & Cooper, C (1997) Determinants of neonatal bone mass. Bone 20, 26S Abstr.Google Scholar
Gale, CR, Martyn, CN, Kellingray, S, Eastell, R & Cooper, C (2001) Intrauterine programming of adult body composition. Journal of Clinical Endocrinology and Metabolism 86, 267–272.Google ScholarPubMed
Gluckman, P & Harding, JE (1992) The regulation of fetal growth. In Human Growth: Basic and Clinical Aspects, pp. 253–260 [Hernandez, M and Argente, J, editors]. Amsterdam: Excerpta Medica.Google Scholar
Hales, CN, Barker, DJP, Clark, PMS, Cox, C, Fall, C, Osmond, C & Winter, PD (1991) Fetal and infant growth and impaired glucose tolerance at age 64 years. British Medical Journal 303, 1019–1022.CrossRefGoogle Scholar
Han, VKM & Fowden, AL (1994) Paracrine regulation of fetal growth. In Early Fetal Growth and Development, pp. 275–291 [Ward, RHT, Smith, SK and Donnai, D, editors]. London: RCOG Press.Google Scholar
Hediger, ML, Overpeck, MD, Kuczmarski, RJ, McGlynn, A, Maurer, KR & Davis, WW (1998) Muscularity and fatness of infants and young children born small- or large-for-gestational-age. Pediatrics 102, E60.CrossRefGoogle ScholarPubMed
Hotta, K, Funahashi, T, Bodkin, NL, Ortmeyer, HK, Arita, Y, Hansen, BC & Matsuzawa, Y (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126–1133.CrossRefGoogle ScholarPubMed
Jennings, BJ, Ozanne, SE, Dorling, MW & Hales, CN (1999) Early growth determines longevity in male rats and may be related to telomere shortening in the kidney. FEBS Letters 448, 4–8.CrossRefGoogle ScholarPubMed
Kahn, AJ (1968) Embryogenic effect on post-natal changes in hemoglobin concentration with time. Growth 32, 13–22.Google Scholar
Kahn, HS, Narayan, KM, Williamson, DF & Valdez, R (2000) Relation of birth weight to lean and fat thigh tissue in young men. International Journal of Obesity and Related Metabolic Disorders 24, 667–672.Google Scholar
Kayo, T, Allison, DB, Weindruch, R & Prolla, TA (2001) Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proceedings of the National Academy of Sciences USA 98, 5093–5098.Google Scholar
Keen, RW, Egger, P, Fall, C, Major, PJ, Lanchbury, JS, Spector, TD & Cooper, C (1997) Polymorphisms of the vitamin D receptor, infant growth and adult bone mass. Calcified Tissue International 60, 233–235.Google Scholar
Kirkwood, TBL & Austad, SN (2000) Why do we age? Nature 408, 233–238.Google Scholar
Lee, CK, Klopp, RG, Weindruch, R & Prolla, TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390–1393.CrossRefGoogle ScholarPubMed
Lucas, A (1991) Programming by early nutrition in man. In The Childhood Environment and Adult Disease. Ciba Foundation Symposium no. 156, pp. 38–50 [Bock, GR and Whelan, J, editors] Chichester, West Sussex: John Wiley.Google Scholar
McCance, RA & Widdowson, EM (1962) Nutrition and growth. Proceedings of the Royal Society of London 156B, 326–337.Google Scholar
Martyn, CN, Barker, DJP, Jesperson, S, Greenwald, S, Osmond, C & Berry, C (1995) Growth in utero, adult blood pressure and arterial compliance. British Heart Journal 73, 116–121.Google Scholar
Medvedev, ZA (1990) An attempt at a rational classification of theories of ageing. Biological Reviews 65, 375–398.CrossRefGoogle Scholar
Mi, J, Law, C, Zhang, KL, Osmond, C, Stein, C & Barker, D (2000) Effects of infant birthweight and maternal body mass index in pregnancy on components of the insulin resistance syndrome in China. Annals of Internal Medicine 132, 253–260.CrossRefGoogle ScholarPubMed
Osmond, C, Barker, DJP, Winter, PD, Fall, CHD & Simmonds, SJ (1993) Early growth and death from cardiovascular disease in women. British Medical Journal 307, 1519–1524.CrossRefGoogle ScholarPubMed
Owens, JA (1991) Endocrine and substrate control of fetal growth: placental and maternal influences and insulin-like growth factors. Reproduction, Fertility and Development 3, 501–517.Google Scholar
Phillips, DIW (1995) Relation of fetal growth to adult muscle mass and glucose tolerance. Diabetic Medicine 12, 686–690.Google Scholar
Ralston, SH (1998) Do genetic markers aid in risk assessment? Osteoporosis International 8, Suppl. 1, S37–S42.Google ScholarPubMed
Rich-Edwards, JW, Stampfer, MJ, Manson, JE, Rosner, B, Hankinson, SE, Colditz, GA, Willett, WC & Hennekens, CH (1997) Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. British Medical Journal 315, 396–400.Google Scholar
Roeder, LM (1973) Effect of the level of nutrition on rates of cell proliferation and of RNA and protein synthesis in the rat. Nutrition Reports International 7, 271–288.Google Scholar
Roeder, LM & Chow, BF (1972) Maternal undernutrition and its long-term effects on the offspring. American Journal of Clinical Nutrition 25, 812–821.Google Scholar
Ross, MH & Lustbader, E (1976) Dietary practices and growth responses as predictors of longevity. Nature 262, 548–553.CrossRefGoogle ScholarPubMed
Roth, GS, Ingram, DK, Black, A & Lane, MA (2000) Effects of reduced energy intake on the biology of ageing: the primate model. European Journal of Clinical Nutrition 54, S15–S20.Google Scholar
Stein, CE, Fall, CH, Kumaran, K, Osmond, C, Cox, V & Barker, DJ (1996) Fetal growth and coronary heart disease in south India. Lancet 348, 1269–1273.Google Scholar
Vehaskari, VM, Aviles, DH & Manning, J (2001) Prenatal programming of adult hypertension in the rat. Kidney International 59, 238–245.CrossRefGoogle ScholarPubMed
Walford, RL, Mock, D, MacCallum, T & Laseter, JL (1999) Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives. Toxicological Science 52, 61–65.Google ScholarPubMed
Weindruch, R & Walford, RL (1988) The Retardation of Aging and Disease by Dietary Restriction. Springfield, IL: Charles C Thomas.Google Scholar
Winick, M & Noble, A (1966) Cellular response in rats during malnutrition at various ages. Journal of Nutrition 89, 300–306.CrossRefGoogle ScholarPubMed