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Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses

Published online by Cambridge University Press:  28 February 2007

Laurence S. Harbige  and
Benjamin A. C. Fisher
Laurence S. Harbige*
Affiliation:
School of Chemical and Life Sciences, University of Greenwich, Wellington Street, London SE18 6PF, UK
Benjamin A. C. Fisher
Affiliation:
School of Chemical and Life Sciences, University of Greenwich, Wellington Street, London SE18 6PF, UK
*
*Corresponding Author: Dr L. S. Harbige, fax +44 20 8331 8305, email [email protected]
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Abstract

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Immunological unresponsiveness or hyporesponsiveness (tolerance) can be induced by feeding protein antigens to naïve animals. Using a classical oral ovalbumin gut-induced tolerance protocol in BALB/c mice we investigated the effects of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on high-and low-dose oral tolerance (and in non-tolerised animals, i.e. effects of antigen challenge alone) in relation to lymphoproliferative, cytokine and antibody responses. Fish oil rich in long-chain n-3 fatty acids decreased both T-helper (Th) 1- and Th2-like responses. In contrast, borage (Borago officinalis) oil rich in n-6 PUFA, of which γ-linolenic acid is rapidly metabolised to longer-chain n-6 PUFA, increased Th1-like responses and decreased Th2-like responses, and possibly enhanced suppressor cell or Th3-like activity. These findings are in general agreement with other studies on the effects of long chain n-3 PUFA on immune system functions, and characterise important differences between long-chain n-3 and n-6 PUFA, defining more precisely and broadly the immunological regulatory mechanisms involved. They are also discussed in relation to autoimmune disease.

Keywords

Dietary n-3 and n-6 fatty acidsCytokine and antibody responsesTolerogenic and antigenic immune responses
Type
Symposium on ‘Dietary influences on mucosal immunity’
Information
Proceedings of the Nutrition Society , Volume 60 , Issue 4 , November 2001 , pp. 449 - 456
Copyright
Copyright © The Nutrition Society 2001

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