Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-27T03:20:27.402Z Has data issue: false hasContentIssue false
  • English
  • Français

Chairman's introduction: What can we expect to learn from genomics?

Published online by Cambridge University Press:  07 March 2007

John C. Mathers
John C. Mathers*
Affiliation:
Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon, Tyne NE1 7RU, UK
*
Corresponding author: Professor John Mathers, fax +44 191 222 8684, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Symposium on ‘How and why measure individual variability’
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 1 , February 2004 , pp. 1 - 4
Copyright
Copyright © The Nutrition Society 2004

References

Bingham, SA (2002) Biomarkers in nutritional epidemiology. Public Health Nutrition 5, 821–827.CrossRefGoogle ScholarPubMed
Brindle, JT, Antti, H, Holmes, E, Tranter, G, Nicholson, JK, Bethell, HWL, Clarke, S, Schofield, PM, McKilligin, E, Mosedale, DE & Grainger, DJ (2002) Rapid and non-invasive diagnosis of the presence and severity of coronary heart disease using 1 H-NMR-based metabonomics. Nature Medicine 8, 1439–1444.CrossRefGoogle Scholar
Daniel, H (2003) Perspectives in post-genomic nutritional research. In Molecular Nutrition, pp. 13–20 [Zempleni, J, Daniel, H, editors]. Wallingford, Oxon. CABI Publishing.CrossRefGoogle Scholar
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41 London H.M. Stationery Office.Google Scholar
Department of Health (2003) Our Inheritance, Our Future. Realising the Potential of Genetics in the NHS. London: The Stationery Office.Google Scholar
Dong, C, Yoon, W & Goldschmidt-Clermont, PJ (2002) DNA methylation and atherosclerosis. Journal of Nutrition 132, 2406S–2409S.CrossRefGoogle ScholarPubMed
Girelli, D, Martinelli, N, Pizzolo, F, Frisco, S, Olivieri, O, Stranieri, C, Trabetti, E, Faccini, G, Tinazzi, E, Pignatti, PF & Corrocher, R (2003) The interaction between MTHFR 677 C→T genotype and folate status is a determinant of coronary atherosclerosis risk. Journal of Nutrition 133, 1281–1285.CrossRefGoogle ScholarPubMed
Grimble, RF, Howell, WM, O'Reilly, G, Turner, SJ, Markovic, O, Hirrell, S, East, JM & Calder, PC (2002) The ability of fish oil to suppress tumor necrosis factor α production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor α production. American Journal of Clinical Nutrition 76, 454–459.CrossRefGoogle ScholarPubMed
Haga, SB, Khoury, MJ & Burke, W (2003) Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nature Genetics 34, 347–350.CrossRefGoogle Scholar
Jaenisch, R & Bird, A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genetics 33, 245–254.CrossRefGoogle ScholarPubMed
James, SJ, Pogribna, M, Pogribny, IP, Melynk, S, Hine, RJ, Gibson, JB, Yi, P, Tafoya, DL, Swenson, DH, Wilson, VL & Gaylor, DW (1999) Abnormal folate metabolism and mutation in methylenetetrahydrofolate reductase (MTHFR) gene may be maternal risk factors for Down syndrome. American Journal of Clinical Nutrition 70, 495–501.CrossRefGoogle ScholarPubMed
Jones, PA & Laird, PW (1999) Cancer epigenetics comes of age. Nature Genetics 21, 163–167.CrossRefGoogle ScholarPubMed
Kim, YI (1999) Folate and carcinogenesis: evidence, mechanisms, and implications. Journal of Nutritional Biochemistry 10, 66–88.CrossRefGoogle ScholarPubMed
Mariadason, J, Corner, GA & Augenlicht, LH (2000) Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: Comparison with trichostatin A, sulindac and curcumin and implications for chemoprevention of colorectal cancer. Cancer Research 60, 4561–4572.Google Scholar
Mathers, JC (2003) Nutrition and cancer prevention; diet–gene interactions. Proceedings of the Nutrition Society 62, 605–610.CrossRefGoogle ScholarPubMed
Mattson, MP (2003) Methylation and acetylation in nervous system development and neurodegenerative disorders. Ageing Research Reviews 2, 329–342.CrossRefGoogle ScholarPubMed
Müller, M & Kersten, S (2003) Nutrigenomics: goals and strategies. Nature Reviews Genetics 4, 315–322.CrossRefGoogle ScholarPubMed
Nicholson, JK, Lindon, JC, Holmes, E (1999) 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181–1189.CrossRefGoogle Scholar
Rampersaud, GC, Kauwell, GPA, Hutson, AD, Cerda, JJ, Bailey, LB (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. American Journal of Clinical Nutrition 72, 998–1003.CrossRefGoogle ScholarPubMed
Richardson, B (2003) Impact of aging on DNA methylation. Ageing Research Reviews 2, 245–261.CrossRefGoogle ScholarPubMed
Strahl, BD & Allis, D (2000) The language of covalent histone modifications. Nature 403, 41–45.CrossRefGoogle ScholarPubMed
Tyers, M & Mann, M (2003) From genomics to proteomics. Nature 422, 193–197.CrossRefGoogle ScholarPubMed
Vincent, S, Plannells, R, Defoort, C, Bernard, M-C, Gerber, M, Prudhomme, J, Vague, P & Lairon, D (2002) Genetic polymorphisms and lipoprotein responses to diets. Proceedings of the Nutrition Society 61, 427–434.CrossRefGoogle ScholarPubMed
Watson, JD & Crick, FHC (1953) Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. Nature 171, 737–738.CrossRefGoogle ScholarPubMed
Widdowson, EM (1936) A study of English diets by the individual method. Part 1. Men. Journal of Hygiene, Cambridge 36, 293–309.CrossRefGoogle Scholar
Zhang, J (2003) Genomics and beyond. In Molecular Nutrition, 1–12 [Zempleni, J, Daniel, H, editors]. Wallingford, Oxon.: CABI Publishing.Google Scholar