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Urinary excretion of benzoic acid and hippuric acid in sheep given ruminal infusion of 3-phenylpropionic and cyclohexanecarboxylic acids

Published online by Cambridge University Press:  05 November 2021

J.H. Pagella ,
X.B. Chen ,
N.A. MacLeod  and
E.R. Ãrskov
J.H. Pagella
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen AB2 9SB, United Kingdom
X.B. Chen
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen AB2 9SB, United Kingdom
N.A. MacLeod
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen AB2 9SB, United Kingdom
E.R. Ãrskov
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen AB2 9SB, United Kingdom
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Extract

Microbial fermentation of lignoceluUosic feeds in the rumen produces 3-phenylpropionic (PPA) and cyclohexanecarboxylic (CHCA) acids. Feed phenolic cinnamic acids are regarded as the main precursors of PPA upon microbial action (Martin 1982b). CHCA can be produced by microbial metabolism of dietary alicyclic compounds such as quinic and shikimic acids (Balba and Evans, 1977; Martin, 1982a). Following absorption CHCA and PPA are subjected to metabolism mainly in the liver yielding benzoic acid (BA) which is extensively excreted in urine mainly as its glycine conjugate hippuric acid (HA). The aim of this work was to assess the quantitative relationship between the urinary excretion of total BA (free BA + HA) and the uptake of PPA and CHCA.

Type
Sheep
Information
Proceedings of the British Society of Animal Science , Volume 1996 , March 1996 , pp. 179
Copyright
Copyright © The British Society of Animal Science 1996

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References

Balba, M.T. and Evans, W.C. 1977. The origin of hexahydrohippurate (cyclohexanoylglycine) in the urine of herbivores. Biochemical Society Transactions 5: 300–302.10.1042/bst0050300CrossRefGoogle ScholarPubMed
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