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Hourly measurement of plasma leptin and cortisol concentrations in non-pregnant ewes under group housing conditions over 23 hours

Published online by Cambridge University Press:  20 November 2017

J. Dandrea ,
S. Pearce ,
G. Davidson ,
C. Morrison ,
P. Goddard ,
D.H. Keisler ,
T. Stephenson  and
M.E. Symonds
J. Dandrea
Affiliation:
Academic Division of Child Health, University Hospital, Nottingham, NG7 2UH, UK
S. Pearce
Affiliation:
Academic Division of Child Health, University Hospital, Nottingham, NG7 2UH, UK
G. Davidson
Affiliation:
Livestock Systems Project, The Macaulay Institute, Craigiebuckler, Aberdeen, AB15 8QH, UK
C. Morrison
Affiliation:
Department of Animal Sciences, University of Missouri, Columbia, Missouri, 65211-5300, USA
P. Goddard
Affiliation:
Livestock Systems Project, The Macaulay Institute, Craigiebuckler, Aberdeen, AB15 8QH, UK
D.H. Keisler
Affiliation:
Department of Animal Sciences, University of Missouri, Columbia, Missouri, 65211-5300, USA
T. Stephenson
Affiliation:
Academic Division of Child Health, University Hospital, Nottingham, NG7 2UH, UK
M.E. Symonds
Affiliation:
Academic Division of Child Health, University Hospital, Nottingham, NG7 2UH, UK
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Extract

The closely related actions of cortisol and leptin (Ahima & Flier, 2000) are involved with appetite, tissue growth and maturation, energy balance and weight deposition so that resistance to either may lead to obesity. In normal weight humans, plasma leptin and cortisol exhibit diurnal variation, peaking during darkness and late afternoon (respectively). In sheep, the literature consensus is that plasma cortisol levels are greatest during daylight. Ovine plasma leptin is also reported to vary in response to photoperiod-driven changes (Bocquier et al., 1998) and such as alterations in voluntary feed intake as daylength changes. Daily circadian patterns, however, are thought to be entrained by the time of daily feed presentation (Marie et al., 2001). The aim of the present study was to investigate the diurnal variation in ovine plasma leptin in unrestrained animals with ad-lib access to hay and water in relation to their plasma cortisol profile over the same period. Remote blood sampling was employed in order to reduce sampling stress that would affect the animals’ plasma physiology.

Type
Poster Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 89
Copyright
Copyright © The British Society of Animal Science 2002

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References

Ahima, R. S. & Flier, J. S. (2000). Leptin. Annual Reviews of Physiology 62: 413–437.CrossRefGoogle ScholarPubMed
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Delavaud, C., Bocquier, F., Chilliard, Y., Keisler, D., Gertler, A. & G, K. (2000). Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. Journal of Endocrinology 165: 519–526.CrossRefGoogle ScholarPubMed
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JD was sponsored by a M.A.F.F. PhD studentship; SP was sponsored by a BBSRC PhD studentship. The project was sponsored by grants from The Society for Endocrinology and The University of Nottingham.Google Scholar