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Effects of intrinsic growth ability and protein nutrition on ability to cope with pathogens in mice

Published online by Cambridge University Press:  23 November 2017

J.C. Coltherd ,
L. Bünger ,
I. Kyriazakis  and
J.G.M Houdijk
J.C. Coltherd*
Affiliation:
Animal Nutrition and Health Team, SAC, Edinburgh, Midlothian, United Kingdom
L. Bünger
Affiliation:
Animal Breeding and Development Team, SAC, Edinburgh, Midlothian, United Kingdom
I. Kyriazakis
Affiliation:
Animal Nutrition and Health Team, SAC, Edinburgh, Midlothian, United Kingdom University of Thessaly, Karditsa, Greece
J.G.M Houdijk
Affiliation:
Animal Nutrition and Health Team, SAC, Edinburgh, Midlothian, United Kingdom
*
Email:[email protected]
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Extract

Selection for narrow breeding goals, such as intrinsic growth ability, may reduce the animals’ ability to cope with pathogen challenge (Rauw et al., 1998). Using mice divergently selected for body weight, it has been shown that selection for high body weight reduced ability to cope with a parasitic challenge under low dietary crude protein (CP) conditions, whilst increasing protein nutrition from 50 to 250g/kg dietary CP reduced the penalty of infection in the high body weight line (Houdijk & Bünger, 2007). However, host resistance was not sensitive to protein nutrition, which may have been due to the observed increased food intake on the low CP diet and/or a reduction of food intake as a consequence of excess protein on the high CP diet. The current experiment addressed these assumptions through assessing interactive effects of intrinsic growth ability and infection at a range of levels of dietary CP contents.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2008 , 2008 , pp. 99
Copyright
Copyright © The British Society of Animal Science 2008

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References

Bünger, L, Laidlaw, A, Bulfield, G, Eisen, E.J., Medrano, J.F., Bradford, G.E., Pirchner, F, Renne, U, Schlote, W and Hill, W.G 2001. Mammalian Genome 12, 678–686.CrossRefGoogle Scholar
Houdijk, J.G.M. and Bünger, L 2007. Proceedings of the British Society of Animal Science, 92–92.Google Scholar
Rauw, W, Kanis, E, Noordhuizen-Stassen, E. N. and Grommers, F.J. 1998. Livestock Production Science 56, 15–33.Google Scholar