Hostname: page-component-669899f699-ggqkh Total loading time: 0 Render date: 2025-04-30T07:16:59.795Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of negative energy balance on expression of the ovarian insulin-like growth factor (IGF) system in the post partum dairy cow

Published online by Cambridge University Press:  23 November 2017

S Llewellyn ,
R Fitzpatrick ,
D A Kenny ,
R J Scaramuzzi  and
D C Wathes
S Llewellyn*
Affiliation:
Royal Veterinary College, London, United Kingdom
R Fitzpatrick
Affiliation:
Teagasc Research Centre, Athenry, Co. Galway, Ireland
D A Kenny
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland
R J Scaramuzzi
Affiliation:
Royal Veterinary College, London, United Kingdom
D C Wathes
Affiliation:
Royal Veterinary College, London, United Kingdom
*
Email: [email protected]
Get access

Extract

Subfertility in lactating cows has a multifactorial background, but a significant cause may be the negative energy balance (NEB) associated with early lactation. One effect of NEB is to delay the interval from calving to first ovulation. The likely candidates for mediating the effects of NEB on reproductive function are the metabolites and metabolic hormones that change in relation to physiological and nutritional state. Circulating IGF-I concentrations fall post partum and both IGF-I and insulin concentrations influence the interval from calving to first ovulation, follicular oestradiol production, and the number of ovulatory oestrogen-active follicles. Moreover, cows with higher IGF-I concentrations after calving generally ovulate within 35 days. Effects of circulating IGF-I on developing follicles are influenced by IGF receptor concentrations and local production of specific binding proteins (IGFBPs). We postulated that severe NEB compromises the early stages of follicular growth via alterations to the follicular IGF system.

Type
Theatre presentations
Information
Proceedings of the British Society of Animal Science , Volume 2006 , March 2006 , pp. 17
Copyright
Copyright © The American Society of International Law 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Jarrige, J. 1989. Eds Agabriel, J., Champciaux, P. and Espinasse, C.. CNERTA, Dijon, France.Google Scholar
Perks, C.M., Peters, A.R & Wathes, D.C. 1999. Follicular and luteal expression of insulin-like growth factors I and II and the type 1 IGF receptor in the bovine ovary. Journal of Reproduction and Fertility 116: 157-165.CrossRefGoogle ScholarPubMed