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Serum leptin concentration in pigs selected for high or low daily food intake

Published online by Cambridge University Press:  20 November 2017

N.D. Cameron ,
J.C. Penman  and
E. McCullough
N.D. Cameron
Affiliation:
Roslin Institute, Roslin, EH25 9PS, Scotland
J.C. Penman
Affiliation:
Roslin Institute, Roslin, EH25 9PS, Scotland
E. McCullough
Affiliation:
Roslin Institute, Roslin, EH25 9PS, Scotland
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Extract

Leptin is synthesised and secreted from adipocytes into the blood stream and transported to the brain, where it acts to cause a release of factors which can reduce food intake (Houseknecht et al., 1998). There are two murine mutations of the recessive gene coding for leptin which are associated with obesity. The Lepob allele determines synthesis and secretion of leptin, while the Lepdb allele determines responsiveness to leptin. In the Edinburgh lean growth experiment in pigs, selection for high and low daily food intake (DFI) has been practiced for seven generations in a Large White herd, which provides the experimental resource to determine if the correlated response in fat deposition is consistent with insufficient leptin production or with insensitivity to leptin.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2000 , 2000 , pp. 22
Copyright
Copyright © The British Society of Animal Science 2000

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References

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