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Published online by Cambridge University Press: 23 November 2017
Scrapie is an invariably fatal, infectious disease of adult sheep and goats characterised by degeneration of the central nervous system. It is one of the Transmissible Spongiform Encephalopathies (TSE), a disease family which includes Bovine Spongiform Encephalopathy (BSE) in cattle, Chronic Wasting Disease (CWD) in deer, and Kuru and variant Creutzfeldt-Jakob Disease (vCJD) in humans. Scrapie was first discovered in European sheep in the early 18th Century and is now present in many sheep populations worldwide.