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Superiority of Colloid over Electrolyte Solution for Severe Normovolemic Hemodilution (NVHD) in Concurrent Treatment of Hemorrhage

Published online by Cambridge University Press:  28 June 2012

Scott Brinkmeyer ,
Peter Safar  and
Etsuro Motoyama
Scott Brinkmeyer
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh. Pittsburgh PA 15260, USA.
Peter Safar
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh. Pittsburgh PA 15260, USA.
Etsuro Motoyama
Affiliation:
From the Resuscitation Research Center and the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh. Pittsburgh PA 15260, USA.
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Extract

Treatment of severe hemorrhage with adequate concurrent administration of plasma substitutes leads to acute normovolemic hemodilution (NVHD). Advantages of hemodilution include: l) reduced risk of infection; 2) decreased thromboembolic phenomena; 3) improved microcirculation; and 4) less use of banked blood resulting in reduced patient cost.

In the 1960's, Takaori and Safar described the types of response to various degrees of hemodilution (HD) and demonstrated that dogs survived when hemodiluted with dextrans to a hematocrit (hct) of 10%. In contrast, HD with Lactated Ringers (LR) was unable to support survival.

Type
Part II: Clinical Care Topics
Information
Prehospital and Disaster Medicine , Volume 1 , supplement S1: Disaster Resuscitology , 1985 , pp. 171 - 172
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

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