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Published online by Cambridge University Press: 28 June 2012
The effect of positive inotropic agents on circulation and ventricular fibrillation threshold are not fully understood during the influence of metabolic acidosis during circulatory arrest. This is the same case with alkalosis, caused by the over-correction of sodium bicarbonate. Furthermore, the role of calcium during CPR is not clear.
Therefore, we investigated the influence of metabolic acidosis and alkalosis with and without the administration of the positive inotropic substances epinephrine and calcium upon contractility and ventricular fibrillation threshold.