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Hyperthermia with Cardiac Arrest, CPR and Irreversible Shock in Monkeys*

Published online by Cambridge University Press:  28 June 2012

John Sassano ,
Gideon Eshel  and
Peter Safar
John Sassano
Affiliation:
From the Resuscitation Research Center, Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
Gideon Eshel
Affiliation:
From the Resuscitation Research Center, Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
Peter Safar
Affiliation:
From the Resuscitation Research Center, Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15260, USA.
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Extract

Each year 4,000–9,000 people die in the USA from hyperthermia-related crises, such as heat stroke and febrile convulsions. In most of these cases, variable combinations of hot environment, physical exercise, dehydration, and infection can be identified. Heat stroke is a complex clinical picture with poorly understood pathophysiology and unexplored resuscitation potentials. Protection of vital organs against hyperthermia is also important for cancer therapy.

This study (1978–1980) was aimed exclusively at the effects of controlled hyperthermia. In pilot experiments on lightly anesthetized dogs and rhesus monkeys, brain temperature was raised to 42°C for 1/2–1 hour by immersion heating. This was followed by cooling to normothermia. Partial recovery with a lucid period of 1 hour or longer was followed by diffuse gastrointestinal bleeding and irreversible shock in spite of standard life support measures.

Type
Part II: Clinical Care Topics
Information
Prehospital and Disaster Medicine , Volume 1 , supplement S1: Disaster Resuscitology , 1985 , pp. 274 - 276
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

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References

1. Shibolet, S, Lancaster, MC, Dannon, Y. Heat stroke: A review. Aviation Space Env Med 1976;47:280.Google ScholarPubMed