Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-03T00:08:37.817Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental Study of Reversibility of a Diazepam Overdose by Physostigmine or Galanthamine

Published online by Cambridge University Press:  28 June 2012

George Havasi ,
Jonas Gintautas ,
Philip R. Warren ,
Ilona Hayasi  and
Barry J. Kraynack
George Havasi
Affiliation:
From the Department of Anesthesiology, Texas Tech University Health Science Center, Lubbock TX, USA.
Jonas Gintautas
Affiliation:
From the Department of Anesthesiology, Texas Tech University Health Science Center, Lubbock TX, USA.
Philip R. Warren
Affiliation:
From the Department of Anesthesiology, Texas Tech University Health Science Center, Lubbock TX, USA.
Ilona Hayasi
Affiliation:
From the Department of Anesthesiology, Texas Tech University Health Science Center, Lubbock TX, USA.
Barry J. Kraynack
Affiliation:
From the Department of Anesthesiology, Texas Tech University Health Science Center, Lubbock TX, USA.
Get access Rights & Permissions [Opens in a new window]

Extract

Diazepam is a commonly used drug for suicidal attempts. The antagonistic effect of physostigmine in these patients is poorly understood.

We studied the interaction of large doses of diazepam and either physostigmine or galanthamine hydrobromide using dose-response curves in 21 cats. After establishing dose-response curves for diazepam, half of the animals received 0.02 mg/kg of physostigmine intravenously. Two minutes later 8, 10, 12, or 14 mg/kg of diazepam was administered intravenously. After 2, 5, and 10 min, animals were evaluated for their response to noise and pain stimuli. The other half of animals were given 0.2 mg/kg of galanthamine intravenously and evaluated for diazepam effect using the same criteria. Sufficient number of days were allowed for the animals to recover from diazepam.

Type
Part II: Clinical Care Topics
Information
Prehospital and Disaster Medicine , Volume 1 , supplement S1: Disaster Resuscitology , 1985 , pp. 287
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)