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Use of Selective Decontamination in the Prevention of Infection After Accidental Irradiation

Published online by Cambridge University Press:  28 June 2012

Itzhak Brook  and
G. David Ledney
Itzhak Brook*
Affiliation:
Wound Infection Management Program, Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5145
G. David Ledney
Affiliation:
Wound Infection Management Program, Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5145
*
PO Box 70412, Chevy Chase, MD 20813-0412USA
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Abstract

Exposure to radiation induces a reduction in the number of gastrointestinal, anaerobic bacterial flora, and an increase in the number of Enterobacteriaceae that are associated with sepsis and mortality. Antimicrobials that suppress anaerobic flora have a deleterious effect on survival by promoting earlier enterobacterial sepsis. In contrast, in studies of animals and immunosuppressed patients, antimicrobials that inhibit gram-negative enteric bacteria and preserve the anaerobic flora have shown a beneficial effect by preventing bacterial translocation and fatal sepsis. The quinolone antimicrobials hold potential for therapy of endogenous and exogenous infection after irrodiation.

Keywords

infectionirradiationquinolonesselective decontaminationsepsis
Type
Collective Review
Information
Prehospital and Disaster Medicine , Volume 8 , Issue 1 , March 1993 , pp. 85 - 88
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1993

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