Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-28T02:52:17.407Z Has data issue: false hasContentIssue false
  • English
  • Français

X-ray powder diffraction data for 1-methylhydantoin, an antiasthmatic and antidepressive hydantoin compound

Published online by Cambridge University Press:  23 April 2015

Gerzon E. Delgado ,
Asiloé J. Mora ,
Jines E. Contreras  and
Cecilia Chacón
Gerzon E. Delgado*
Affiliation:
Laboratorio de Cristalografía, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela
Asiloé J. Mora
Affiliation:
Laboratorio de Cristalografía, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela
Jines E. Contreras
Affiliation:
Laboratorio de Cristalografía, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela
Cecilia Chacón
Affiliation:
Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada-Instituto Politécnico Nacional, México D.F. 11500, México
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

X-ray powder diffraction data, unit cell parameters, and space group for 1-methylhydantoin, C4H6N2O2, are reported [a = 5.6070(9) Å, b = 12.170(1) Å, c = 8.097(1) Å, β = 105.41(1), Z = 4, unit cell volume V = 532.66(9) Å3, with M20 = 50.2 and F30 = 62.2 (0.0082, 59)]. All measured lines were indexed and are consistent with the monoclinic P21/c space group.

Keywords

X-ray powder diffraction1-methylhydantoinantiasthmaticantidepressive
Type
New Diffraction Data
Information
Powder Diffraction , Volume 30 , Issue 2 , June 2015 , pp. 178 - 181
Check for updates
Copyright
Copyright © International Centre for Diffraction Data 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, F. H. (2002). “The Cambridge Structural Database: a quarter of a million crystal structures and rising,” Acta Crystallogr. B 58, 380–388.Google Scholar
Baune, B. T. and Renger, L. (2014). “Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression – a systematic review,” Psychiat. Res. 219, 25–50.Google Scholar
Boultif, A. and Louër, D. (2004). “Powder pattern indexing with the dichotomy method,” J. Appl. Crystallogr. 37, 724–731.CrossRefGoogle Scholar
CSD Cambridge Structure Database (2014). version 5.35, Cambridge Crystallographic Data Centre, Cambridge, UK.Google Scholar
Delgado, G. E., Mora, A. J., Uzcátegui, J., Bahsas, A., and Briceño, A. (2007). “(S)-5-benzylimidazolidine-2,4-dione monohydrate,” Acta Crystallogr. C 63, o448–o450.CrossRefGoogle ScholarPubMed
Delgado, G. E., Seijas, L. E., and Mora, A. J. (2012). “Synthesis and crystal structure determination of hydantoin-L-proline,” J. Chem. Cryst. 42, 968–971.CrossRefGoogle Scholar
de Wolff, P. M. (1968). “A simplified criterion for the reliability of a powder pattern indexing,” J. Appl. Crystallogr. 1, 108–113.CrossRefGoogle Scholar
Han, D., Dong, X. L., and Qiu, Z. D. (2014). “Antiasthmatic effect of 1-methylhydantoin on rat asthma model and its mechanism,” J. Jilin Univ. Med. Ed. 40, 543–548.Google Scholar
ICDD (2011). PDF-2 2011 (Database), edited by Kabekkodu, S., International Centre for Diffraction Data, Newtown Square, PA, USA.Google Scholar
Le Bail, A. (2005). “Whole powder pattern decomposition methods and applications: a retrospection,” Powder Diffr. 20, 316–326.Google Scholar
López, C. A. and Trigo, G. G. (1985). “The chemistry of hydantoins,” Adv. Heterocycl. Chem. 38, 177–228.Google Scholar
Merrit, H. H. and Putnam, T. J. (1938). “A new series of anticonvulsant drugs tested by experiments on animals,” Arch. Neurol. Psychiatry 39, 1003–1015.Google Scholar
Meusel, M. and Gütschow, M. (2004). “Recent developments in hydantoin chemistry. A review,” Org. Prep. Proced. Int. 36, 391–443.CrossRefGoogle Scholar
Mighell, A. D., Hubbard, C. R., and Stalick, J. K. (1981). NBS*AIDS80: A Fortran program for crystallographic data evaluation. National Bureau of Standards (USA), Technical Note 1141.Google Scholar
Mutschler, E. and Derendorf, H. (1995). Drug Actions, Basic Principles and Therapeutic Aspects (Medpharm Scientific Publishers, Stuttgart).Google Scholar
Nogueira, B. A., Ildiz, G. O., Canotilho, J., Eusébio, M. E. S., and Fausto, R. (2014). “Molecular structure, infrared spectra, photochemistry, and thermal properties of 1-methylhydantoin,” J. Phys. Chem. A, 118, 5994–6008.Google Scholar
Park, K. H., Ehrler, J., Spoerri, H., and Kurth, M. J. (2001). “Preparation of a 990-member chemical compound library of hydantoin- and isoxazoline-containing heterocycles using multipin technology,” J. Comb. Chem. 3, 171–176.CrossRefGoogle ScholarPubMed
Puszynska-Tuszkanow, M., Daszkiewicz, M., Maciejewska, G., Staszak, Z., Wietrzyk, J., Filip, B., and Cieslak-Golonka, M. (2011). “HSAB principle and nickel(II) ion reactivity towards 1-methyhydantoin,” Polyhedron 30, 2016–2025.Google Scholar
Rodriguez-Carvajal, J (2014) Fullprof, version 5.3, LLB, CEA-CNRS, France.Google Scholar
Seijas, L. E., Mora, A. J., Delgado, G. E., Brunelli, M., and Fitch, A. N. (2010). “Study of the conversion of N-carbamoyl-L-proline to hydantoin-L-proline using powder synchrotron X-ray diffraction,” Powder Diffr. 25, 342–348.Google Scholar
Smith, G. S. and Snyder, R. L. (1979). “FN: a criterion for rating powder diffraction patterns and evaluating the reliability of powder-pattern indexing,” J. Appl. Crystallogr. 12, 60–65.CrossRefGoogle Scholar
Yang, B., Liu, D., Li, C. Z., Liu, F. Y., Peng, Y. M., and Jiang, Y. S. (2007). “1-methylhydantoin cytotoxicity on renal proximal tubular cells in vitro ,” Ren Fail. 29, 1025–1029.Google Scholar
You, J. S., Zhang, R. R., Wang, C. G., Shi, J. L., Guo, J. Y., Shi, S. N., Hou, W. H., and Liu, Y. (2013). “Effects of 1-methylhydantoin on behavior changes in depressive rats and its possible mechanisms,” Chin. Phar. Bull. 29, 1104–1108.Google Scholar
Supplementary material: File

Delgado supplementary material

Delgado supplementary material 1

Download Delgado supplementary material(File)
File 94.2 KB