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A practical guide to pharmaceutical analyses using X-ray powder diffraction

Published online by Cambridge University Press:  15 April 2019

T. G. Fawcett ,
S. Gates-Rector ,
A. M. Gindhart ,
M. Rost ,
S. N. Kabekkodu ,
J. R. Blanton  and
T. N. Blanton Open the ORCID record for T. N. Blanton [Opens in a new window]
T. G. Fawcett*
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
S. Gates-Rector
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
A. M. Gindhart
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
M. Rost
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
S. N. Kabekkodu
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
J. R. Blanton
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
T. N. Blanton
Affiliation:
International Centre for Diffraction Data, Newtown Square, Pennsylvania 19073
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected]
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Abstract

Advances in instrumentation, software applications, and database content have all contributed to improvements in pharmaceutical analyses by powder diffraction methods in the 21st century. When compared to the globally harmonized United States Pharmacopeia General Chapter <941>, “Characterization of Crystalline and Partially Crystalline Solids by X-ray Powder Diffraction”, many historic problems in pharmaceutical analysis have been addressed by combinations of improved methods and instrumentation. Major changes in the last 20 years include (i) a dramatic lowering in detection capability and detection limits, (ii) enhanced capabilities for dynamic measurements such as in situ analyses under a variety of conditions, and (iii) the ability to identify and characterize nanomaterials, non-crystalline, and amorphous materials by both coherent and incoherent scattering profiles.

Keywords

pharmaceuticalsguidepowder diffraction
Type
Review Article
Information
Powder Diffraction , Volume 34 , Issue 2 , June 2019 , pp. 164 - 183
Copyright
Copyright © International Centre for Diffraction Data 2019 

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