Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-24T14:42:32.412Z Has data issue: false hasContentIssue false
  • English
  • Français

Powder X-ray diffraction of levothyroxine sodium pentahydrate, C15H10I4NNaO4(H2O)5

Published online by Cambridge University Press:  11 November 2015

J.A. Kaduk ,
K. Zhong ,
T.N. Blanton ,
S. Gates  and
T.G. Fawcett
J.A. Kaduk
Affiliation:
Illinois Institute of Technology, 3101 S. Dearborn St., Chicago, Illinois 60616
K. Zhong
Affiliation:
International Centre for Diffraction Data, 12 Campus Blvd., Newtown Square, Pennsylvania 19073-3273
T.N. Blanton*
Affiliation:
International Centre for Diffraction Data, 12 Campus Blvd., Newtown Square, Pennsylvania 19073-3273
S. Gates
Affiliation:
International Centre for Diffraction Data, 12 Campus Blvd., Newtown Square, Pennsylvania 19073-3273
T.G. Fawcett
Affiliation:
International Centre for Diffraction Data, 12 Campus Blvd., Newtown Square, Pennsylvania 19073-3273
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected] Data were submitted via Genie (http://www.icdd.com/websubmission/launch.html), the ICDD® Web Submission Page.
Get access Rights & Permissions [Opens in a new window]

Abstract

The room-temperature crystal structure of levothyroxine sodium pentahydrate has been refined using synchrotron powder diffraction data. The compound crystallizes in space group P1 (#1) with a = 8.2489(4), b = 9.4868(5), c = 15.8298(6) Å, α = 84.1387(4), β = 83.1560(3), γ = 85.0482(3) deg, V = 1220.071(9) Å3, and Z = 2. Hydrogen atoms (missing from the previously-reported structure) were included.

Keywords

levothyroxine sodiumSynthroiddensity functional theoryRietveld refinement
Type
Data Reports
Information
Powder Diffraction , Volume 30 , Issue 4 , December 2015 , pp. 370 - 371
Copyright
Copyright © International Centre for Diffraction Data 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, F. H. (2002). “The Cambridge Structural Database: a quarter of a million crystal structures and rising,” Acta Crystallogr. Sect. B: Struct. Sci. 58, 380–388. CSD Refcode QQQETG01.Google Scholar
Katrusiak, A. and Katrusiak, A. (2004). “Thyroxine revisited,” J. Pharm. Sci. 93(12), 3066–3075.Google Scholar

Kaduk supplementary material

Kaduk supplementary material 1

Download Kaduk supplementary material(Audio)
Audio 848.5 KB