Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-02T21:06:46.387Z Has data issue: false hasContentIssue false

X-ray powder diffraction data for letrozole (C17H11N5)

Published online by Cambridge University Press:  02 September 2015

Yan Mei Huang
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Hong Qin Yang
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Shou Jun Zheng
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Pei Xiao Tang
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
Hui Li*
Affiliation:
College of Chemical Engineering, Sichuan University, Chengdu 610065, China
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected]

Abstract

X-ray powder diffraction data, unit-cell parameters, and space group for letrozole, C17H11N5, are reported [a = 7.034(0) Å, b = 16.177(5) Å, c = 13.411(3) Å, α = γ = 90°, β = 105.71(9)°, unit-cell volume V = 1469.0(3) Å3, Z = 4, and space-group P21/c]. All measured lines were indexed and are consistent with the P21/c space group. No detectable impurity was observed.

Type
Data Reports
Copyright
Copyright © International Centre for Diffraction Data 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cohen, M. H., Johnson, J. R., Li, N., Chen, G., and Pazdur, R. (2002). “Approval summary letrozole in the treatment of postmenopausal women with advanced breast cancer,” Clin. Cancer Res. 8, 665669.Google ScholarPubMed
Geisler, J., Helle, H., Ekse, D., Duong, N. K., Evans, D. B., Nordbø, Y., Aas, T., and Lønning, P. E. (2008). “Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels,” Clin. Cancer Res. 14, 63306335.Google Scholar
Harris, K. D. M. (2012). “Powder diffraction crystallography of molecular solids,” Top. Curr. Chem. 315, 133178.CrossRefGoogle ScholarPubMed
Pan, Q. Q., Guo, P., Duan, J., Cheng, Q., and Li, H. (2012). “Comparative crystal structure determination of griseofulvin: powder X-ray diffraction versus single-crystal X-ray diffraction,” Chin. Sci. Bull. 57, 38673871.Google Scholar
Wang, J., Bei, F. L., Li, R. Y., Yang, X. J., and Wang, X. (2004). “Synthesis, characterization and single crystal structure of 4,4′-(1H-1,2,4triazol-1-methylene) -bisbenzonitrile,” Youji Huaxue 24, 550553.Google Scholar
Xu, X. Y., Ma, W. X., Wang, J., Chen, H. H., Yang, X. J., and Wang, X. (2002). “Crystal structure of 4,4′-(1-H-1,2,4-triazol-1-ylmethylene)bis(benzonitrile),” Huaihai Gongxueyuan Xuebao 11, 3033.Google Scholar
Supplementary material: Image

Huang supplementary material

Huang supplementary material 1

Download Huang supplementary material(Image)
Image 97.5 KB
Supplementary material: File

Huang supplementary material

Huang supplementary material 2

Download Huang supplementary material(File)
File 43.2 KB