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Cover to provide an inert atmosphere for XRD sample changers

Published online by Cambridge University Press:  10 January 2013

Charles Buckner  and
Peter Varlashkin
Charles Buckner
Affiliation:
Advanced Design and Automation, Glaxo Wellcome, Inc., Five Moore Drive, PO Box 13398, Research Triangle Park, North Carolina 27709
Peter Varlashkin
Affiliation:
Pharmaceutics and Chemical Analysis, Glaxo Wellcome, Inc., Five Moore Drive, PO Box 13398, Research Triangle Park, North Carolina 27709
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Abstract

A cover for Scintag's six and twelve-position sample changers was designed and constructed to provide an inert atmosphere for samples during diffraction batch runs. The cover is equipped with inlet and outlet gas ports and fits over the top of the sample changer. Using dry nitrogen gas fed into the inlet of the cover, a sample of lithium bromide was protected from atmospheric moisture for greater than 18 h. The cover uses a thin Mylar window that gives greater than 95% transparency for copper K-alpha X-rays. The cover is a simple device that allows our lab to run multiple moisture-sensitive samples in a batch mode. The simple approach and materials used in the construction of the cover could be applied to other brands of powder diffractometers.

Type
Technical Articles
Information
Powder Diffraction , Volume 15 , Issue 2 , June 2000 , pp. 101 - 103
Copyright
Copyright © Cambridge University Press 2000

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References

Buckner, C., Kidd, C., Long, S., Varlashkin, P., and Zhu, J. (1999). “Environmentally-controlled sample stage for Scintag's six-position XRD sample changer,” Powder Diff. 14, 296–299.CrossRefGoogle Scholar
Nyqvist, H. (1983). “Saturated salt solutions for maintaining specified relative humidities,” Int. J. Pharm. Tech. & Prod. Mfr. 4, 47–48.Google Scholar