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Atenolol characterization in solid formulations available in Brazilian market

Published online by Cambridge University Press:  14 November 2013

S. T. B. Salvi ,
S. G. Antonio  and
C. O. Paiva-Santos
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Abstract

Atenolol is the most used drug in Brazil to hypertension treatment. Two crystal structures are known for this molecule: a racemic form (R,S)-atenolol and a pure form S-atenolol. The racemic form is found in commercial tablets. X-ray powder diffraction (XRD) is an adequate tool to study crystalline structures including drugs. Using the Rietveld Method with XRD data it is possible to quantify the crystalline structures existing in the raw material. Other methods like Le Bail and Pawley can be used to the profile fit and phases identification. For this work we analyzed three tablets of atenolol, two generics and the reference (materials were purchased from a drugstore at the city of Araraquara). These tablets were analyzed by Rietveld, Le Bail and Pawley methods. All tablets exhibited the racemic mixture API (R,S)-atenolol. Some crystalline excipients could be characterized: magnesium carbonate hydrate, lactose monohydrate and talc. The conclusion is that the three methods can be efficiently used to characterize the three atenolol tablets.

Keywords

AtenololX-ray powder diffractionRietveld MethodLe Bail MethodPawley Method
Type
Technical Articles
Information
Powder Diffraction , Volume 28 , Supplement S2 , September 2013 , pp. S448 - S457
Copyright
Copyright © International Centre for Diffraction Data 2013 

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References

Akao, M. and Iwai, S. (1977). “The hydrogen bonding of hydromagnesite,” Acta Crystallogr., Sect. B: Struct. Sci. 33, 1273–1275.Google Scholar
Brasil, P. (2010). Saúde anuncia dados da hipertensão no País. Avalilable: http://www.brasil.gov.br/noticias/arquivos/2011/04/25/saude-anuncia-dados-da-hipertensao-no-pais [Accessed: 26/09/2012 at 09:25 A.M.].Google Scholar
Coelho, A. A. (2007). Topas-Academic, version v4.1 (Computer Software), Coelho Software, Brisbane.deGoogle Scholar
Castro, R. A. E., Canotilho, J., Barbosa, R. M., Silva, M. R., Beja, A. M., Paixa, J. A., and Redinha, J. S. E. (2007). “Conformational isomorphism of organic crystals: Racemic and homochiral atenolol,” Cryst. Growth Des. 7, 496–500.Google Scholar
Fries, D. C., Rao, S. T. and Sundaralingam, M. (1971). “Structural chemistry of carbohydrates. III. Crystal and molecular structure of 4-O-β-d-galactopyranosyl-α-d-glucopyranose monohydrate (α-lactose monohydrate),” Acta Crystallogr., Sect. B: Struct. Crystallogr. Cryst. Chem. 27, 994–1005.Google Scholar
Gendre, C., Genty, M., Silva, J. C. D., Tfayli, A., Boiret, M., Lecoq, O., Baron, M., Chaminade, P. and Péan, J. M. (2012). “Comprehensive study of dynamic curing effect on tablet coating structure,” Eur. J. Pharm. Biopharm. 81, 657–665.Google Scholar
Le Bail, A., Duroy, H. and Fourquet, J. L. (1988). “Ab-initio structure determination of LiSbWO6 by X-ray powder diffraction,” Mater. Res. Bull. 23, 447–452.Google Scholar
Lima, V. L. E. (1997). “Os fármacos e a quiralidade: uma breve abordagem,” Quim. Nova. 20, 657–663.Google Scholar
Marques, L. (2011). Brasil terá remédios para hipertensão e diabetes grátis. Avalilable: http://veja.abril.com.br/noticia/saude/governo-distribuira-remedios-para-hipertensao-e-diabetes-gratis [Accessed: 28/09/2012 at 10:25 A.M.].Google Scholar
Pawley, G. (1981). “Unit-cell refinement from powder diffraction scans,” J. Appl. Crystallogr. 14, 357–361.Google Scholar
Pearson, A. A., Gaffney, T. E., Walle, T. and Privitera, P. J. (1989). “A stereoselective central hypotensive action of atenolol,” J. Pharmacol. Exp. Ther. 250, 759–763.Google Scholar
Rayner, J. H. and Brown, G. (1973). “Crystal-structure of talc,” Clays Clay Miner. 21, 103–114.Google Scholar
Rietveld, H. M. (1969). “A profile refinement method for nuclear and magnetic structures,” J. Appl. Crystallogr. 2, 65–71.Google Scholar
Scarlett, N. V. Y. and Madsen, I. C. (2006). “Quantification of phases with partial or no known crystal structures,” Powder Diffr. 21, 278–284.Google Scholar
Swaminathan, V. and Kildsig, D. (2001). “An examination of the moisture sorption characteristics of commercial magnesium stearate,” AAPS PharmSciTech 2, 73–79.Google Scholar
Wada, Y. and Matsubara, T. (1994). “Pseudopolymorphism and Lubricating Properties of Magnesium Stearate,” Powder Technol. 78, 109–114.Google Scholar