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Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin

Published online by Cambridge University Press:  05 July 2012

James Cockram ,
Colin Hill ,
Corrinne Burns ,
Randoph R. J. Arroo ,
Jack G. Woolley ,
Ian Flockart ,
Trevor Robinson ,
Christopher J. Atkinson ,
Michael J. Davies  and
Nigel Dungey
...Show all authors
James Cockram*
Affiliation:
John Bingham Laboratory, National Institute of Agricultural Botany (NIAB), Huntington Road, Cambridge CB3 0LE, UK
Colin Hill
Affiliation:
Extraction Technology Developments Ltd, 10 Myrtle Green, Ashford TN23 3QN, UK
Corrinne Burns
Affiliation:
Natural Products Research, The School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
Randoph R. J. Arroo
Affiliation:
Natural Products Research, The School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
Jack G. Woolley
Affiliation:
Natural Products Research, The School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
Ian Flockart
Affiliation:
Botanical Developments Ltd, Benover Road, Yalding, Maidstone ME18 6ET, UK
Trevor Robinson
Affiliation:
Frontier Agriculture Ltd, Witham St. Hughes, Lincoln LN6 9TN, UK
Christopher J. Atkinson
Affiliation:
East Malling Research, New Road, East, Malling ME19 6BJ, UK
Michael J. Davies
Affiliation:
East Malling Research, New Road, East, Malling ME19 6BJ, UK
Nigel Dungey
Affiliation:
Humber VHB, Pharma Unit, Runcton Nursery, Chichester PO20 1LJ, UK
Andy J. Greenland
Affiliation:
John Bingham Laboratory, National Institute of Agricultural Botany (NIAB), Huntington Road, Cambridge CB3 0LE, UK
Lydia L. M. J. Smith
Affiliation:
John Bingham Laboratory, National Institute of Agricultural Botany (NIAB), Huntington Road, Cambridge CB3 0LE, UK
Steven Bentley
Affiliation:
John Bingham Laboratory, National Institute of Agricultural Botany (NIAB), Huntington Road, Cambridge CB3 0LE, UK
*
*Corresponding author. E-mail: [email protected]
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Abstract

The antimalarial drug artemisinin (ART) is commercially extracted from the medicinal plant Artemisia annua L. Here, we report the screening of 70 A. annua plants representing 14 diverse germplasm accessions sourced from around the world, and identify lines containing >2% ART. These extremely high-yielding individuals have been maintained as vegetative clones, and they represent promising germplasm resources for future A. annua breeding programmes.

Keywords

chemovarplant pre-breedingPlasmodium falciparum
Type
Short Communication
Information
Plant Genetic Resources , Volume 10 , Issue 2 , August 2012 , pp. 152 - 154
Copyright
Copyright © NIAB 2012

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