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Improvement of medicinal plant quality: a Hypericum perforatum literature review as an example

Published online by Cambridge University Press:  12 February 2007

A. Poutaraud  and
P. Girardin
A. Poutaraud*
Affiliation:
National Institute for Agricultural Research (INRA)28, rue de Herrlisheim, F-68021, Colmar, France
P. Girardin
Affiliation:
National Institute for Agricultural Research (INRA)28, rue de Herrlisheim, F-68021, Colmar, France
*
*Corresponding author: E-mail: [email protected]
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Abstract

Numerous factors influence the chemical quality of medicinal plants from crop establishment to extraction of raw material. The most important ones are described using the example of Hypericum perforatum. Optimization of these factors contributes to the objective of producing a high-quality drug, and a method consisting of three scientific approaches (technological, agronomical, plant breeding) is presented. All data concerning the plant (biology, physiology and environmental impacts) and the active components and by-products (pathway, localization and stability) are useful to adapt and to develop management sequences. Although plant breeding appears to be the principal way of improvement, and gives good results in terms of resistance to pathogens, active component content and yield; the agronomical and the technological approaches are also very important. The technological approach after harvesting is especially important to avoid degradation of the active components and to induce, in some cases, the transformation of by-products to those molecules sought. This integrated method (plant breeding and agronomical and chemical approaches) requires research on different levels of organization from molecule to field, and includes all processing systems from farmers to chemists.

Keywords

agronomydrugHypericum perforatummedicinal plantplant breedingquality
Type
Research Article
Information
Plant Genetic Resources , Volume 3 , Issue 2 , August 2005 , pp. 178 - 189
Copyright
Copyright © INRA 2005

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References

Arnholdt-Schmitt, B (2000) RAPD analysis: a method to investigate aspects of the reproductive biology of Hypericum perforatum L. Theoretical and Applied Genetics 100: 906–911.CrossRefGoogle Scholar
Azizi, M and Omid-Beigi, R (2001) Effects of different levels of nitrogen and phosphorus fertilizer on growth, yield and hypericin content of St John's wort. Iranian Journal of Agricultural Sciences 32: 720–725.Google Scholar
Bais, HP, Vepachedu, R, Lawrence, CB, Stermitz, FR and Vivanco, JM (2003) Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St John's wort (Hypericum perforatum L.). Journal of Biological Chemistry 278: 32413–32422.CrossRefGoogle Scholar
Baricevic, D, Umek, A, Kreft, S, Maticic, B and Zupancic, B (1999) Effect of water stress and nitrogen fertilization on the content of hyoscyamine and scopolamine in the roots of deadly nightshade (Atropa belladonna). Environmental and Experimental Botany 42: 17–24.CrossRefGoogle Scholar
Bergonzi, MC, Bilia, AR, Gallori, S, Guerrini, D and Vincieri, FF (2001) Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts. Drug Development and Industrial Pharmacy 27: 491–497.CrossRefGoogle ScholarPubMed
Bernath, J (2002) Strategies and recent achievements in selection of medicinal and aromatic plants. Acta Horticulturae 576: 115–128.CrossRefGoogle Scholar
Bombardelli, E and Morazonni, P (1995) Hypericum perforatum. Fitoterapia 116: 43–67.Google Scholar
Bottcher, H, Gunther, I and Kabelitz, L (2003) Physiological postharvest responses of Common Saint-John's wort herbs (Hypericum perforatum L.). Postharvest Biology and Technology 29: 343–351.CrossRefGoogle Scholar
Brantner, A, Kartnig, T and Quehenberger, F (1994) Comparative phytochemical investigations of Hypericum perforatum L. and Hypericum maculatum Crantz. Scientia Pharmaceutica 62: 261–276.Google Scholar
Briskin, DP and Gawienowski, MC (2001) Differential effects of light and nitrogen on production of hypericins and leaf glands in Hypericum perforatum. Plant Physiology and Biochemistry 39: 1075–1081.CrossRefGoogle Scholar
Briskin, DP, Leroy, A and Gawienowski, M (2000) Influence of nitrogen on the production of hypericins by St John's wort. Plant Physiology and Biochemistry 38: 413–420.CrossRefGoogle Scholar
Brutovska, R, Cellarova, E and Dolezel, J (1998) Cytogenetic variability of in vitro regenerated Hypericum perforatum L. plants and their seed progenies. Plant Science 133: 221–229.CrossRefGoogle Scholar
Brutovska, R, Kusnirikova, P, Bogyiova, E and Cellarova, E (2000) Karyotype analysis of Hypericum perforatum L. Biologia Plantarum 43: 133–136.CrossRefGoogle Scholar
Büter, B, Soldati, A, Schaffner, W and, Berger, K (1996) Site specific dry matter and concentrations of hypericin, biflavons and cadmium in different Hypericum ssp. accessions (first year results). Paper presented at Breeding Research on Medicinal and Aromatic Plants, Quedlinburg, Germany.Google Scholar
Büter, B, Orlacchio, C, Soldati, A and Berger, K (1998 a) Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum. Planta Medica 64: 431–437.CrossRefGoogle ScholarPubMed
Büter, KB, Schraner, E, Schaffner, W and, Büter, B (1998 b) Genetic diversity within and among Hypericum perforatum populations collected in a geographical narrow and wide area. Paper presented at the 46th Annual Congress of the Society for Medicinal Plant Research—Quality of Medicinal Plants and Herbal Medicinal Products, Vienna.Google Scholar
Butterweck, V, Petereit, F, Winterhoff, H and Nahrstedt, A (1998) Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Medica 64: 291–294.CrossRefGoogle ScholarPubMed
Butterweck, V, Christoffel, V, Nahrstedt, A, Petereit, F, Spengler, B and Winterhoff, H (2003) Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models. Life Sciences 73: 627–639.CrossRefGoogle ScholarPubMed
Cellarova, E, Kimakova, GM and Brutovska, R (1992) Multiple shoot formation and phenotypic changes of Ro regenerants in Hypericum perforatum L. Acta Biotechnologica 12: 445–452.CrossRefGoogle Scholar
Cellarova, E, Daxnerova, K, Kimakova, K and Haluskova, K (1994) The variability of hypericin content in the regenerants of Hypericum perforatum. Acta Biotechnologica 14: 267–274.CrossRefGoogle Scholar
Cellarova, E, Brutovska, R, Daxnerova, Z, Brunakova, K and Weigel, RC (1997) Correlation between hypericin content and the ploidy of somaclones of Hypericum perforatum L. Acta Biotechnologica 17: 83–90.CrossRefGoogle Scholar
Chappell, J and Hahlbrock, K (1984) Transcription of plant defence genes in response to UV light or fungal elicitor. Nature 311: 76–78.CrossRefGoogle Scholar
Chatterjee, SK, Nandi, RP, Bharati, P, Yonjan, B and Yonzon, MK (1988) Improvement studies on some alkaloid yielding medicinal plants. Acta Horticulturae 39–46.Google Scholar
Chatterjee, SS, Noldner, M, Koch, E and Erdelmeier, C (1998) Antidepressant activity of Hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry 31: 7–15.CrossRefGoogle ScholarPubMed
Ciccarelli, D, Andreucci, AC and Pagni, AM (2001) Translucent glands and secretory canals in Hypericum perforatum L. (Hypericaceae): morphological, anatomical and histochemical studies during the course of ontogenesis. Annals of Botany 88: 637–644.CrossRefGoogle Scholar
Cott, JM (1997) in vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry 30: 108–112.CrossRefGoogle ScholarPubMed
Curtis, JD and Lersten, NR (1990) Internal secretory structures in Hypericum (Clusiaceae): H. perforatum L. and H. balearicum L. New Phytologist 114: 571–580.CrossRefGoogle Scholar
Debrunner, N, Darbellay, C, Slacanin, I and, Ryser, A (1997) Selection of Hypericum perforatum L. populations resistant to fungal pathogens. Paper presented at the World Congress on Medicinal and Aromatic Plants for Human Welfare, ICMAP ISHS SAIPA, Mendoza, Argentina.Google Scholar
Denke, A, Schempp, H, Mann, E, Schneider, W and Elstner, EF (1999) Biochemical activities of extracts from Hypericum perforatum L.—4th communication: influence of different cultivation methods. Arzneimittel—Forschung—Drug Research 49: 120–125.Google Scholar
Dias, ACP, Majid, A and, Reza, O (2001) Effect of nitrogen and phosphorus fertilisation in the cultivation of Hypericum perforatum variety Topas. Paper presented at the International Congress and 49th Annual Meeting of the Society of Medicinal Plant Research, Erlange, Germany.Google Scholar
Franke, R, Heisig, W and Muggenburg, D (1993) Quality variation in some medicinal plants. Acta Horticulturae 333: 123–127.CrossRefGoogle Scholar
Franke, R, Schenk, R, Bauermann, U (1998) Variability in Hypericum perforatum L. breeding lines. Paper presented at the 46th Annual Congress of the Society for Medicinal Plant Research—Quality of Medicinal Plants and Herbal Medicinal Products, Vienna.Google Scholar
Franke, R, Schenk, R, Bauermann, U (2000) Variability in Hypericum perforatum L. breeding lines. Paper presented at Wocmap—2: Second World Congress on Medicinal and Aromatic Plants for Human Welfare.Google Scholar
Freytag, WE (1984) Bestimmung von, Hypericin un Nachweis von Pseudohypericin in Hypericum perforatum L. durch HPLC. Deutsche Apotheker Zeitung 124: 2383–2386.Google Scholar
Gaedcke, F (1997) Herstellung, Qualitat, Analytik und Anwendung von Johanniskraut-Extraken. Zeitschrift für Arzneimittel aus Gewürzpflanzen 2: 63–72.Google Scholar
Gasic, O, Petrovic, M and Cank, N (1978) Determination of microelement in soil and the investigation of their correlation with the quantity of total isolated alkaloids and colchicine in Colchicum autumnale L. collected from various regions. Planta Medica 33: 276Google Scholar
Gaudin, M, Simmonet, X and Debrunner, N (1999) Sélection d'une variété de millepertuis productive et peu sensible au dépérissement. Revue Suisse de Victiculture, Arboriculture et Horticulture 31: 335–341.Google Scholar
Gaudin, M, Simmonet, X and Debrunner, N (2002) Breeding for a Hypericum perforatum L. variety both productive and Colletotrichum gloeosporoides (penz.) tolerant. Journal of Herbs, Spices and Medicinal Plants 9: 107–120.CrossRefGoogle Scholar
Girzu, MA, Carnat, A, Fraisse, D, Carnat, AP and Lamaison, JL (2000) Flavonoid and dianthranoid levels of the St John's Wort flowering tops. Annales Pharmaceutiques Francaises 58: 341–345.Google Scholar
Granzow, D and, Holzl, J (1998) Isolation of hyperforin from Hypericum perforatum and its stability in organic solvents and extracts. Paper presented at the 46th Annual Congress of the Society for Medicinal Plant Research—Quality of Medicinal Plants and Herbal Medicinal Products, Vienna.Google Scholar
Greenfield, AJ, Mead, DJ, Pwer, JB, Lowe, KC and Davey, MR (1998) Toward hypericin production from fermenter grown cultures of Hypericum perforatum. Abstracts— Plants and Plant Cell Topics C2 11: 89Google Scholar
Haluskova, J and Cellarova, E (1997) RFLP analysis of Hypericum perforatum L. somaclones and their progenies. Euphytica 95: 229–235.CrossRefGoogle Scholar
Hölzl, J and Ostrowski, E (1987) Johnanniskraut (Hypericum perforatum L.). HPLC-Analyse der wichtigen Inhalsstoffe und deren Varibialität in einer Population. Deutsche Apotheker Zeitung 23: 1227–1230.Google Scholar
Hornok, L (1992) Cultivation and Processing of Medicinal Plants. Chichester: John Wiley and SonsGoogle Scholar
Jurgenliemk, G and Nahrstedt, A (2003) Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems. Pharmazie 58: 200–203.Google ScholarPubMed
Kartnig, T, Gruber, A and Sauer, H (1989) Comparative phytochemical investigations of Hypericum species. Planta Medica 55: 215CrossRefGoogle Scholar
Kartnig, T, Gobel, I and Heydel, B (1996) Production of hypericin, pseudohypericin and flavonoids in cell culture in various Hypericum species and their chemotypes. Planta Medica 62: 51–53.CrossRefGoogle Scholar
Kirakosyan, A, Hayashi, H, Inoue, K, Charchoglyan, A and Vardapetyan, V (2000) Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures. Phytochemistry 53: 345–348.CrossRefGoogle ScholarPubMed
Kosuth, J, Koperdakova, J, Tolonen, A, Hohtola, A and Cellarova, E (2003) The content of hypericins and phloroglucinols in Hypericum perforatum L. seedlings at early stage of development. Plant Science 165: 515–521.CrossRefGoogle Scholar
Liu, FF (2000) Optimization of extraction conditions for active components in Hypericum perforatum using response surface methodology. Journal of Agricultural and Food Chemistry 48: 3364–3371.CrossRefGoogle ScholarPubMed
Martonfi, P, Brutovska, R, Cellarova, E and Repcak, M (1996) Apomixis and hybridity in Hypericum perforatum. Folia Geobotanica & Phytotaxonomica 31: 389–396.CrossRefGoogle Scholar
Matzk, F, Meister, A, Brutovská, R and Schubert, I (2001) Reconstruction of reproductive diversity in Hypericum perforatum L. opens novel strategies to manage apomixis. The Plant Journal 26: 275CrossRefGoogle ScholarPubMed
Mayo, GM and Langridge, P (2003) Modes of reproduction in Australian populations of Hypericum perforatum L. (St John's wort) revealed by DNA fingerprinting and cytological methods. Genome 46: 573–579.CrossRefGoogle Scholar
Melnikova, V, Vainshtein, V and, Shikov, A (1998) New appoaches to the technology of oil and water-alcohol extracts of Hypericum perforatum L. Paper presented at the 46th Annual Congress of the Society for Medicinal Plant Research—Quality of Medicinal Plants and Herbal Medicinal Products, Vienna.Google Scholar
Mennini, T and Gobbi, M (2004) The antidepressant mechanism of Hypericum perforatum. Life Sciences 75: 1021–1027.CrossRefGoogle ScholarPubMed
Mohr, T, Hecht, H and Eichhorn, H (1996) Comparative examinations of an improved picking machine for the flower harvest of Chamomilla recutita L. (St. Rauschert), Calendula officinalis L. and Hypericum perforatum L. Drogenreport 9: 15–23.Google Scholar
Murch, SJ, Rupasinghe, HPV and Saxena, PK (2002) An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St John's wort (Hypericum perforatum CV new stem). Planta Medica 68: 1108–1112.CrossRefGoogle Scholar
Murch, SJ, Haq, K, Rupasinghe, HPV and Saxena, PK (2003) Nickel contamination affects growth and secondary metabolite composition of St John's wort (Hypericum perforatum L.). Environmental and Experimental Botany 49: 251–257.CrossRefGoogle Scholar
Nahrstedt, A and Butterweck, V (1997) Biologically active and other chemical constituents of the herb from Hypericum perforatum L. Pharmacopsychiatry 30: 129–134.CrossRefGoogle ScholarPubMed
Nathan, PJ (2001) Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. Journal of Psychopharmacology 15: 47–54.CrossRefGoogle ScholarPubMed
Nielsen, N (1924) Chromosome numbers in the genus Hypericum. Hereditas 5: 372–382.Google Scholar
Oravec, Sen V, Oravec, Jun V, Matonfi, P and Repcak, M (1994) Variability pattern in different cultivated Hypericum perforatum types Paper presented at Cultivation and Improvement of Medicinal and Aromatic Plants TrentoGoogle Scholar
Orth, H, Rentel, C and Schmidt, P (1999) Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L. Journal of Pharmacy and Pharmacology 51: 193–200.CrossRefGoogle ScholarPubMed
Pank, F (1990) The influence of chemical weed control on quality characters of medicinal and aromatic plants. Herba Hungarica 29: 51–58.Google Scholar
Pank, F (2002) Three approaches to the development of high performance cultivars considering the differing biological background of the starting material. Acta Horticulturae 576: 129–137.CrossRefGoogle Scholar
Pank, F, Matzk, F, Kastner, U, Bluthner, WD de, Garcia, EF, Meister, A, Ryschka, U and Schumann, G (2003) Reproductive diversity and strategies for breeding in St John's wort (Hypericum perforatum L.). Euphytica 134: 77–84.CrossRefGoogle Scholar
Pasqua, G, Avato, P, Monacelli, B, Santamaria, AR and Argentieri, MP (2003) Metabolites in cell suspension cultures, calli, and in vitro regenerated organs of Hypericum perforatum cv. Topas. Plant Science 165: 977–982.CrossRefGoogle Scholar
Phillipson, JD (2003) Fifty years of medicinal plant research—every progress in methodology is a progress in science. Planta Medica 69: 491–495.Google Scholar
Pietta, P, Gardana, C and Pietta, A (2001) Comparative evaluation of St John's wort from different Italian regions. Il Farmaco 56: 491–496.CrossRefGoogle ScholarPubMed
Ploss, O, Petereit, F and Nahrstedt, A (2001) Procyanidins from the herb of Hypericum perforatum. Pharmazie 56: 509–511.Google ScholarPubMed
Pluhár, Z, Bernáth, J and Németh, E (2002) Investigations on the infraspecific variability of Hypericum perforatum L. Journal of Herbs, Spices and Medicinal Plants 9: 83–88.CrossRefGoogle Scholar
Poutaraud, A and Girardin, P (2004) Agronomic and chemical characterisation of 39 Hypericum perforatum L. accessions between 1998 and 2000. Plant Breeding 123: 480–484.CrossRefGoogle Scholar
Poutaraud, A Di, Gregorio, F, Chan, Fook, Tin, V and Girardin, P (2001 a) Effect of light on hypericins contents in fresh flowering top parts and in an extract of St John's Wort (Hypericum perforatum). Planta Medica 67: 254–259.CrossRefGoogle Scholar
Poutaraud, A, Lobstein, A, Girardin, P and Weniger, B (2001 b) Improved procedure for the quality control of Hypericum perforatum L. Phytochemical Analysis 12: 355–362.CrossRefGoogle ScholarPubMed
Pretto, FR and Santarem, ER (2000) Callus formation and plant regeneration from Hypericum perforatum leaves. Plant Cell, Tissue and Organ Culture 62: 107–113.CrossRefGoogle Scholar
Repcak, M and Martonfi, P (1997) The localization of secondary substances in Hypericum perforatum flower. Biologia 52: 91–94.Google Scholar
Santarem, ER and Astarita, LV (2003) Multiple shoot formation in Hypericum perforatum L. and hypericin production. Brazilian Journal of Plant Physiology 15: 43–47.CrossRefGoogle Scholar
Schilter, B, Andersson, C, Anton, R, Constable, A, Kleiner, J, O'Brien, J, Renwick, AG, Korver, O, Smit, F and Walker, R (2003) Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food and Chemical Toxicology 41: 1625–1649.CrossRefGoogle ScholarPubMed
Seidler-Lozykowska, K and Dabrowska, J (1996) Topaz—the Polish variety of St John's wort (Hypericum perforatum L.). Herba Polonica 42: 140–143.Google Scholar
Singer, A, Wonnemann, M and Muller, WE (1999) Hyperforin, a major antidepressant constituent of St John's Wort, inhibits serotonin uptake by elevating free intracellular Na+. Journal of Pharmacology and Experimental Therapeutics 290: 1363–1368.Google Scholar
Sirvent, T and Gibson, D (2002) Induction of hypericins and hyperforin in Hypericum perforatum L. in response to biotic and chemical elicitors. Physiological and Molecular Plant Pathology 60: 311–320.CrossRefGoogle Scholar
Southwell, IA and Bourke, CA (2001) Seasonal variation in hypericin content of Hypericum perforatum L. (St John's Wort). Phytochemistry 56: 437–441.CrossRefGoogle ScholarPubMed
Southwell, IA and Campbell, MH (1991) Hypericin content variation in Hypericum perforatum in Australia. Phytochemistry 30: 475–478.CrossRefGoogle Scholar
Steck, N, Messmer, M, Schaffner, W and Bueter, KB (2001) Molecular markers as a tool to verify sexual and apomictic off-spring of intraspecific crosses in Hypericum perforatum. Planta Medica 67: 384–385.CrossRefGoogle ScholarPubMed
Tekel'ova, A, Repcak, M and Zemkova, E (2000) Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum. Planta Medica 66: 778–780.CrossRefGoogle ScholarPubMed
Tetenyi, P (1991) Biological preconditions for cultivation and processing of medicinal plants. In: The Medicinal Plant Industry, Boca Raton, FL: CRC Press, 33–41.Google Scholar
Umek, A, Kreft, S, Kartnig, T and Heydel, B (1999) Quantitative phytochemical analyses of six Hypericum species growing in Slovenia. Planta Medica 65: 388–390.CrossRefGoogle ScholarPubMed
Upton, RE (1997) St John's Wort quality control analytical and therapeutic monograph. HerbalGram 40: 1–32.Google Scholar
Walker, L, Sirvent, T, Gibson, D and Vance, N (2001) Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the northwestern United States. Canadian Journal of Botany 79: 1248–1255.CrossRefGoogle Scholar
Wierzchowska-Renke, K, Zobel, AM, Glowniak, K (1995) Effect of fertilizing with copper and manganese on content of coumarin in Pasticana sativa L. 43rd Annual Congress on Medicinal Plant Research. G: Cultivation of Plants (abstract G3), Halle (Saale), Germany, p. 45.Google Scholar
Wills, RBH, Bone, K and Morgan, M (2000) Herbal products: active constituents, modes of action and quality control. Nutrition Research Reviews 13: 47–77.CrossRefGoogle ScholarPubMed
Yu, K, Hahn, E and Paek, K (2001) Effects of NH 4+: NO 3? ratio and ionic strength on adventitious root growth and ginsenoside production in bioreactor culture of Panax ginseng C.A. Meyer. Acta Horticulturae 560: 259–262.Google Scholar
Zobayed, SMA and Saxena, PK (2003) in vitro -grown roots: a superior explant for prolific shoot regeneration of St John's wort (Hypericum perforatum L. cv ‘New Stem’) in a temporary immersion bioreactor. Plant Science 165: 463–470.CrossRefGoogle Scholar
Zobayed, SMA, Murch, SJ, Rupasinghe, HPV and Saxena, PK (2003) Elevated carbon supply altered hypericin and hyperforin contents of St John's wort (Hypericum perforatum) grown in bioreactors. Plant Cell, Tissue and Organ Culture 75: 143–149.CrossRefGoogle Scholar
Zobel, AM, Crellin, J, Brown, SA and Gloniak, K (1994) Concentration of furanocoumarins under stress conditions and their histological localization. Acta Horticulturae 381: 510–516.CrossRefGoogle Scholar