Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-25T07:18:38.230Z Has data issue: false hasContentIssue false
  • English
  • Français

Genomic and ploidy manipulation for enhanced production of phyto-pharmaceuticals

Published online by Cambridge University Press:  12 February 2007

U.C. Lavania
U.C. Lavania*
Affiliation:
Central Institute of Medicinal and Aromatic Plants, Lucknow, 226 015, India
*
*Corresponding author: E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Polyploidization is often accompanied by increased cell size and conspicuous changes in secondary metabolism. Where vegetative plant organs are the source of secondary metabolites, as is the case with most medicinal plants, ploidy manipulations such as direct chromosome doubling or allopolyploidization provide a rapid means to realize enhanced production of phyto-pharmaceuticals. Supported with prospective examples, this article illustrates the potential of genomic and ploidy manipulation to enhance the resourcing of pharmaceuticals of plant origin and suggests some appropriate strategies for optimum utilization.

Keywords

medicinal plantsphyto-pharmaceuticalsploidy manipulationpolyploid breedingpolyploidysecondary metabolism
Type
Research Article
Information
Plant Genetic Resources , Volume 3 , Issue 2 , August 2005 , pp. 170 - 177
Copyright
Copyright © NIAB 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alston, RE, Rosler, H, Naifeh, K and Mabri, TJ (1965) Hybrid compounds in natural interspecific hybrids. Proceedings of the National Academy of Sciences USA 54: 1458–1465.CrossRefGoogle ScholarPubMed
Andreev, VS (1963) The increase of morphine content in polyploids of opium poppy (Papaver somniferum L.). Doklady Akademii Nauk SSSR 148: 206–208.Google Scholar
Banerjee, PK (1968) Variation of chemical content with change in chromosome number. In: Sharma, AK and Sharma, A (eds) Proceedings of the International Seminar on Chromosomes Nucleus (Supplement). Calcutta: University of Calcutta, 324–331.Google Scholar
Barber, HN (1970) Hybridization and evolution of plants. Taxon 19: 154–160.CrossRefGoogle Scholar
Berkov, S (2001) Size and alkaloid content of seeds in induced autotetraploids of Datura innoxia, Datura stramonium and Hyoscyamus niger. Pharmaceutical Biology 39: 329–331.CrossRefGoogle Scholar
Berkov, S and Philipov, S (2002) Alkaloid production in diploid and autotetraploid plants of Datura stramonium. Pharmaceutical Biology 40: 617–621.CrossRefGoogle Scholar
Berkov, S, Pavlov, A, Kovatcheva, P, Stanimirova, P and Philipov, S (2003) Alkaloid spectrum in diploid and tetraploid hairy root cultures of Datura stramonium. Zeitschrift für Naturforschung 58: 42–46.CrossRefGoogle ScholarPubMed
Bhatt, B and Heble, MR (1978) Improvement of solasodine content in fruits of spiny and mutant tetraploid of Solanum khasianum Clarke. Environmental and Experimental Botany 18: 127–130.CrossRefGoogle Scholar
Cullis, C and Davies, DR (1974) Ribosomal RNA cistron number in a polyploid series of plants. Chromosoma 46: 23–28.CrossRefGoogle Scholar
de Jesus-Gonzalez, L and Weathers, PJ (2003) Tetraploid Artemisia annua hairy roots produce more artemisinin than diploids. Plant Cell Reports 21: 809–813.CrossRefGoogle ScholarPubMed
de Wet, JMJ (1980) Origin of polyploids. In: Lewis, WH (ed.) Polyploidy—Biological Relevance. New York: Plenum Press, 3–16.CrossRefGoogle Scholar
Dhawan, OP and Lavania, UC (1996) Enhancing the productivity of secondary metabolites via induced polyploidy: a review. Euphytica 87: 81–89.CrossRefGoogle Scholar
Evans, WC (1996) Genetic aspects. In: Trease and Evans' Pharmacognosy, 14th edn. London: WB Saunders Company, 87–99.Google Scholar
Galitski, T, Saldanha, AJ, Styles, CA, Lander, ES and Fink, GR (1999) Ploidy regulation of gene expression. Science 285: 251–254.CrossRefGoogle ScholarPubMed
Gao, SL, Zhu, DN, Cai, ZH and Xu, DR (1996 a) Autotetraploid plants from colchicine treated bud culture of Salvia miltiorrhiza Bge. Plant Cell, Tissue and Organ Culture 47: 73–77.CrossRefGoogle Scholar
Gao, SL, Zhu, DN, Cai, ZH and Xu, DR (1996 b) The relation between characters and crude drug quality in polyploid lines of danshen. Journal of Plant Resources and Environment 5: 1–4.Google Scholar
Goswami, R, Tyagi, BR, Rani, A, Uniyal, GC and Kumar, S (1996) Colchicine induced auto-tetraploids in periwinkle, Catharanthus roseus. Journal of Medicinal and Aromatic Plant Sciences 18: 38–45.Google Scholar
Griesbach, RJ and Kamo, KK (1996) The effect of induced polyploidy on the flavonoids of Petunia Mitchell. Phytochemistry 42: 361–363.CrossRefGoogle Scholar
Guo, M, Davis, D and Birchler, JA (1996) Dosage effect on gene expression in a maize ploidy series. Genetics 142: 1349–1355.CrossRefGoogle Scholar
Janaki-Ammal, EK and Prasad, PN (1984) Relationship between polyploidy and diosgenin content in different parts of Costus speciosus (Koen) Sm. Currrent Science 53: 601–602.Google Scholar
Jenkins, G and Chatterjee, R (1995) Search for structural component for homology. In: Brandham, PE and Bennett, MD (eds) Kew Chromosome Conference IV. Kew: Royal Botanic GardensGoogle Scholar
Khosla, MK, Bradu, BL and Gupta, SC (1990) Polyploidy breeding in Ocimum for evolving high yielding, better quality strains of essential oil importance. In: Bhattacharya, SC, Sen, N and Sethi, KL (eds) Biosciences 3. London: Aspect Publishing Press 75–80.Google Scholar
Krishnan, R, Chandravadana, MV, Mohankumar, GN and Ramachander, PR (1985) Effect of induced autotetraploidy on alkaloid content and root weight in Catharanthus roseus L.G. Don. Herba Hungarica 24: 43–51.Google Scholar
Lavania, UC (1986) Genetic improvement of Egyptian henbane, Hyoscyamus muticus L. through induced tetraploidy. Theoretical and Applied Genetics 73: 292–298.CrossRefGoogle ScholarPubMed
Lavania, UC (1988 a) Enhanced productivity of the essential oil in the artificial autopolyploid of vetiver (Vetiveria zizanioides L. Nash). Euphytica 38: 271–276.CrossRefGoogle Scholar
Lavania, UC (1988 b) Development of fertile autotetraploid strain in Hyoscymus muticus L. Tropical Agriculture 65: 277–278.Google Scholar
Lavania, UC (1995) Genesis of high bivalent pairing in autotetraploids and autotriploids, and reduction in bound arm associations over generations. In: Brandham, PE and Bennett, MD (eds) Kew Chromosome Conference IV. Kew: Royal Botanic Gardens, 397–406.Google Scholar
Lavania, UC and Srivastava, S (1990) Evolutionary genomic change paralleled by differential responses in 2x and 4x calli cultures. Experientia 46: 322–324.CrossRefGoogle Scholar
Lavania, UC and Srivastava, S (1991) Enhanced productivity of tropane alkaloids and fertility in artificial autotetraploids of Hyoscyamus niger L. Euphytica 52: 73–77.CrossRefGoogle Scholar
Levin, DA (2002) The Role of Chromosomal Change in Plant Evolution. New York: Oxford University PressCrossRefGoogle Scholar
Levy, M (1976) Altered glycoflavone expression in induced autotetraploids of Phlox drummondi. Biochemical Systematics and Ecology 4: 249–259.CrossRefGoogle Scholar
Mable, BK (2003) Breaking down taxonomic barriers in polyploidy research. Trends in Plant Science 8: 582–590.CrossRefGoogle ScholarPubMed
Manwell, C and Baker, CM (1970) Molecular Biology and Origin of Species. Seattle: University of WashingtonGoogle Scholar
Masterson, J (1994) Stomatal size in fossil plants: evidence for polyploidy in majority of angiosperms. Science 264: 421–423.CrossRefGoogle ScholarPubMed
Mears, JA (1980) Chemistry of polyploids. A summary with comments on Parthenium (Asteraceae-Ambrosiinae). In: Lewis, WH (ed.) Polyploid: Biological Relevance. New York: Plenum Press, 77–101.CrossRefGoogle Scholar
Melcher, E and Huan, N (1981) Alkaloid content in trisomic mutants of Datura stramonium. Planta Medica 42: 102–103.Google Scholar
Milo, J, Levy, A, Palevitch, D and Ladizinsky, G (1987) Thebaine content and yield in induced tetraploid and triploid plants of Papaver bracteatum Lindl. Euphytica 36: 361–367.CrossRefGoogle Scholar
Nakai, Y (1977) Variation of esterase isozymes and some soluble proteins in diploids and their induced autotetraploids in plants. Japanese Journal of Genetics 52: 171–181.Google Scholar
Osborn, TC, Pires, JC, Birchler, JA, Auger, DL, Chen, ZJ, Lee, H-S, Comai, L, Madlung, A, Doerge, RW, Colot, V and Martienssen, RA (2003) Understanding mechanisms of novel gene expression in polyploids. Trends in Genetics 19: 141–147.CrossRefGoogle ScholarPubMed
Otto, SP and Whitton, J (2000) Polyploid incidence and evolution. Annual Review of Genetics 34: 401–437.CrossRefGoogle ScholarPubMed
Owuor, JBO (1985) Interspecific hybridization between Coffea arabica L. and tetraploid C. canephora P. EXFr.II. Meiosis in F 1 hybrids and back crosses to C. arabica.. Euphytica 34: 355–360.CrossRefGoogle Scholar
Repcák, M, Eliasová, A, Ruscancinová, A (1998) Production of herniarin by diploid and tetraploid Chamomilla recutita. Pharmazie 53: 278–279.Google Scholar
Rudolph, W and Schwartz, P (1951) Polyploidie effekte bei Datura tatula. Plant 39: 36–64.Google Scholar
Sardzhveladze, GP and Kharebava, LG (1990) Studies on the raw material and made tea of the polyploid No. 2582-VICh II of the cultivar Kolkhida. Subtroicheskie Kultury 4: 52–57.Google Scholar
Schwartz, D and Laughner, W (1969) A molecular basis for heterosis. Science 166: 626–627.CrossRefGoogle ScholarPubMed
Silvarolla, MB, Mazzafera, P, Lima, MMA, de Medina Filho, HP and Fazuoli, LC (1999) Ploidy level and caffeine content in leaves of Coffea. Scientia Agricola 56: 661–663.CrossRefGoogle Scholar
Srivastava, S and Lavania, UC (1990) Meiotic regularization, restoration of seed fertility and alkaloid content in the induced autotetraploids of Hyoscyamus albus L. Plant Breeding 104: 160–166.CrossRefGoogle Scholar
Stebbins, GL (1971) Chromosomal Evolution in Higher Plants. London: Addison WesleyGoogle Scholar
Svehlíková, V and Repcák, M (2000) Variation of apigenin quantity in diploid and tetraploid Chamomilla recutita (L.) Rauschert. Plant Biology 2: 403–407.CrossRefGoogle Scholar
Tal, M (1980) Physiology of polyploids. In: Lewis, WH (ed.) Polyploidy: Biological Relevance. New York: Plenum Press, 61–75.CrossRefGoogle Scholar
Wallaart, TE, Pras, N and Quax, WJ (1999) Seasonal variations of artemisinin and its biosynthetic precursors in tetraploid Artemisia annua plants compared with the wild-type. Planta Medica 65: 723–728.CrossRefGoogle Scholar
Wendel, JF (2000) Genome evolution in polyploids. Plant Molecular Biology 42: 225–249.CrossRefGoogle ScholarPubMed
Wold, JK, Paulsen, BS, Ellingsen, DF and Nordal, A (1983) Increase in thebaine content of Papaver bracteatum Lindl after polyploidization with colchicine. Nordic Pharmaceutica Acta 45: 103–109.Google Scholar