Published online by Cambridge University Press: 01 January 2022
Occam’s razor refers to the idea that among competing explanations the simplest should be preferred. This principle has been understood and defended in different ways. Some systems biologists argue that traditional molecular biology is misguided because it relies on an unjustified application of Occam’s razor. I analyze which version of the principle is relevant in this context and ask whether the allegation stands up to scrutiny by looking at actual research. I defend the traditional approach by arguing that its use of Occam’s razor is innocuous and by showing that systems biology heavily relies on considerations of simplicity as well.
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The biologist Johnjoe McFadden defends Occam’s razor against people like Westerhoff in the same spirit, by appealing to the ability of simple models to make “sharper predictions.” See https://www.youtube.com/watch?v=VvpWiV3WtLQ.