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Wolbachia as a possible means of driving genes into populations

Published online by Cambridge University Press:  16 March 2011

C. F. Curtis  and
S. P. Sinkins
C. F. Curtis
Affiliation:
London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
S. P. Sinkins
Affiliation:
London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
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Summary

Cytoplasmic incompatibility consists of sterility in cross matings, the crossing type being maternally inherited. It can be explained by the action of Wolbachia symbionts which are transmitted through the egg cytoplasm and leave an imprint on the sperm which prevents it fertilizing unless it is ‘rescued’ by the action of the same type of Wolbachia in the egg. Thus matings between infected males and uninfected females are sterile, but the reciprocal matings are fertile. Hence uninfected females are at risk of failing to transmit their uninfected cytoplasm if they cross mate, but infected females are at no such risk. Therefore natural selection favours the infected state and in two wild insect populations the infection has been observed spreading. If a gene for inability to transmit malaria could be introduced into Wolbachia and if this could be introduced into Anopheles (where these symbionts appear not to occur naturally), release of a limited number of such insects should trigger a process of displacement of malaria vectors, by the non-vector type. A simple model is used to demonstrate the limitations to this process which would be introduced by immigration.

Keywords

cytoplasmic inheritanceWolbachiaCulexAnophelesgenetic controlimmigration.
Type
Research Article
Information
Parasitology , Volume 116 , supplement S1: Symposia of the British Society for Parasitology Volume 35: Parasite-insect interactions: reciprocal manipulation , 1998 , pp. S111 - S115
Copyright
Copyright © Cambridge University Press 1998

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References

Braig, H. R., Guzman, H., Tesh, R. B. & O'Neill, S. L. (1994). Replacement of the natural Wolbachia symbiont of Drosophila simulans with a mosquito counterpart. Nature 367, 453–455.CrossRefGoogle Scholar
Caspari, E. & Watson, G. S. (1959). On the evolutionary importance of cytoplasmic sterility in mosquitoes. Evolution 13, 568–570.CrossRefGoogle Scholar
Curtis, C. F. (1968). Possible use of translocations to fix desirable genes in insect pest populations. Nature 218, 368–369.CrossRefGoogle ScholarPubMed
Curtis, C. F. (1976). Population replacement by means of cytoplasmic incompatibility, 2. Field cage experiments with overlapping generations. Bulletin of the World Health Organization 53, 107–119.Google Scholar
Curtis, C. F. (1992). Selfish genes in mosquitoes. Nature 357, 450.CrossRefGoogle Scholar
Curtis, C. F. & Graves, P. M. (1988). Methods for replacement of malaria vector populations. Journal of Tropical Medicine and Hygiene 91, 43–48.Google Scholar
Duravasula, R. V., Gumbs, A., Panackal, A., Kruglov, O., Aksoy, S., Merrifield, R. B., Richards, F. F. & Beard, C. B. (1997). Prevention of insect borne disease: an approach using transgenic symbiotic bacteria. Proceedings of the National Academy of Sciences, USA 94, 3274–3278.CrossRefGoogle Scholar
Fine, P. E. M. (1978). On the dynamics of symbiotedependent cytoplasmic incompatibility in culicine mosquitoes. Journal of Invertebrate Pathology 30, 10–18.CrossRefGoogle Scholar
Ghelelovitch, S. (1952). Sur le determinisme génétique de la sterilité dans les croisements entre différentes souches de Culex autogenicus. Comptes Rendus de I'Académie des Sciences, Paris 234, 2386–2388.Google Scholar
Hertig, M. (1936). The rickettsia Wolbachia pipientis and associated inclusions of the mosquito Culex pipiens. Parasitology 28, 453–490.CrossRefGoogle Scholar
Hoshizaki, S. & Shimada, T. (1995). PCR based detection of Wolbachia in natural populations of Laodelphax striatellus in central Japan. Insect Molecular Biology 4, 237–243.CrossRefGoogle Scholar
Kidwell, M. G. & Ribeiro, J. M. C. (1992). Can transposable elements be used to drive disease refractoriness genes into vector populations? Parasitology Today 8, 325–329.CrossRefGoogle Scholar
Laven, H. (1959). Speciation by cytoplasmic incompatibility in the Culex pipiens complex. Cold Spring Harbor Symposia on Quantitative Biology 24, 166–173.CrossRefGoogle Scholar
Laven, H. (1967). Eradication of Culex pipiens fatigans by cytoplasmic incompatibility. Nature 216, 383–384.CrossRefGoogle Scholar
Marshall, J. F. (1938). The British Mosquitoes, London, British Museum, Natural History.Google Scholar
O'Neill, S. L.Giordano, R., Colbert, A. M., Karr, T. L. & Robertson, H. M. (1992). 16S rRNA phylogenetic analysis of the bacterial endosymbionts associated with cytoplasmic incompatibility in insects. Proceedings of the National Academy of Sciences, USA 89, 2699–2702.Google Scholar
O'Neill, S. L. & Karr, T. L. (1990). Bidirectional incompatibility between conspecific populations of Drosophila simulans. Nature 348, 178–180.CrossRefGoogle Scholar
Singh, K. R. P., Curtis, C. F. & Krishnamurthy, B. S. (1976). Partial loss of cytoplasmic incompatibility with age in males of Culex fatigans. Annals of Tropical Medicine and Parasitology 70, 463–466.CrossRefGoogle Scholar
Sinkins, S. P. (1996). Wolbachia as a potential gene driving system. Ph.D. thesis, University of London.Google Scholar
Sinkins, S. L., Braig, H. R. & O'Neill, S. L. (1995). Wolbachia superinfections and the expression of cytoplasmic incompatibility. Proceedings of the Royal Society B 261, 325–330.CrossRefGoogle Scholar
Sinkins, S. P., Curtis, C. F. & O'Neill, S. L. (1997). The potential application of inherited symbiont systems to pest control. In Influential Passengers, (ed. O'Neill, S. L., Hoffmann, A. A. and Werren, J. H.), pp. 155–175. Oxford, Oxford University Press.CrossRefGoogle Scholar
Turelli, M. & Hoffmann, A. A. (1991). Rapid spread of an inherited incompatibility factor in Californian Drosophila. Nature 353, 440–442.CrossRefGoogle Scholar
Turelli, M., Hoffmann, A. A. & McKechnie, S. W. (1992). Dynamics of cytoplsmic incompatibility and mtDNA variation in natural Drosophila simulans populations. Genetics 132, 713–723.CrossRefGoogle Scholar
Werren, J. H., Zhang, W. & Guo, L. R. (1995). Evolution and phylogeny of Wolbachia. Proceedings of the Royal Society B 261, 55–63.CrossRefGoogle Scholar
Yen, J. H. & Barr, A. R. (1973). The etiological agent of cytoplasmic incompatibility in Culex pipiens. Journal of Invertebrate Pathology 22, 242–250.CrossRefGoogle ScholarPubMed