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Variation in class-specific humoral immune responses of different mouse strains to microfilariae of Dipetalonema viteae

Published online by Cambridge University Press:  06 April 2009

N. M. Almond ,
M. J. Worms ,
W. Harnett  and
R. M. E. Parkhouse
N. M. Almond
Affiliation:
Divisions of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
M. J. Worms
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
W. Harnett
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
R. M. E. Parkhouse*
Affiliation:
Divisions of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
*
†Reprint requests to Dr R. M. E. Parkhouse.
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Summary

The class-specific antibody responses of 3 strains of mice (C57/Bl10, BALB/C and CBA/N) known to vary in their ability to control the microfilaraemia which follows the subcutaneous transplantation of adult female Dipetalonema viteae has been investigated. The 3 mouse strains showed significant variation (a) in total levels of immunoglobulins and (b) in ability to recognize individual radio-isotope-labelled antigens as measured by coprecipitation. Within each mouse strain it was noted that antigens could vary with respect to the nature of the isotype of the antibody response which they elicited. Furthermore, by comparing results obtained from class-specific coprecipitation with surface ELISA it was found that a similar variation between responses to individual epitopes was also likely. No differences were observed in the humoral response of the 3 mouse strains which could explain the known resistance of the C57/B110 strain; reasons for this are discussed.

Type
Research Article
Information
Parasitology , Volume 95 , Issue 3 , December 1987 , pp. 559 - 568
Copyright
Copyright © Cambridge University Press 1987

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