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Uptake of [14C]oxamniquine by Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

N. M. Woolhouse  and
B. Kaye
N. M. Woolhouse
Affiliation:
Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ
B. Kaye
Affiliation:
Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ
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Extract

The uptake and retention of drug-related material by Schistosoma mansoni was studied in the mouse host following a single oral or intramuscular does (50 mg/kg) of [14C]oxamniquine. Male worms took up more labelled material than did female worms but the amount in each particular sex of worm was found to be similar after both routes of administration. Exposure of worms was therefore independent of the route of administration. Six days after drug administration, at the time of an hepatic shift, significantly more drug-related material* was present in male worms than in female worms. Examination of worms recovered from mice 4 h after treatment showed that metabolites of oxamniquine constituted 70–90% of the drug-related material present in the worms. Both sexes of worms were able to take up matebolites of oxamniquine win vitro.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 1 , August 1977 , pp. 111 - 118
Copyright
Copyright © Cambridge University Press 1977

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References

REFERENCES

Blair, D. M. & Weber, M. C. (1975). Oral oxamniquine in the treatment of persistent Schistosoma mansoni bilharziasis. Central African Journal of Medicine 21, 24–6.Google ScholarPubMed
Coutinho, A., Domingues, A. L. C. & Bonfim, J. R. A. (1973). Treatment of mansoni schistosomiasis with oxamniquine. Revista do Instituto de Medicrina Tropical de Sao Paulo 15, (Suppl. 1), 15–34.Google Scholar
Domingues, A. L. C. & Coutinho, A. (1975). Tratamento da esquistossomose mansonica com oxamniquine oral. Revista do Instituto de Medicina Tropical de Sao Paulo 17, 164–80.Google ScholarPubMed
Eyakuse, V. M. (1973). A clinical trial of oxamniquine (UK-4271) by large intramuscular dose against schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de Sao Paulo 15 (Suppl. 1), 67–72.Google Scholar
Foster, R. & Cheetham, B. L. (1973). Studies with the schistosomicide oxamniquine (UK-4271) I. Activity in rodents and in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 674–84.CrossRefGoogle ScholarPubMed
Foster, R., Cheetham, B. L. & King, D. F. (1973). Studies with the schistosomicide oxamniquine (UK-4271) II. Activity in primates. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 685–93.CrossRefGoogle ScholarPubMed
Katz, N., Pellegrino, J., Grinbaum, E., Chaves, A. & Zicker, F. (1973). Further clinical trials with oxaminiquine, a new antischistosomal agent. Revista do Instituto de Medicina Tropical de Sao Paulo 15, (Suppl. 1), 35–40.Google ScholarPubMed
Kaye, B. & Woolhouse, N. M. (1972). The metabolism of a new schistosomicide, 2-isopropylaminomethyl–6-methy1–7-nitro-1,2,3,4-tetrahydroquinoline (UK 3883). Xenobiotica 2, 169–78.CrossRefGoogle Scholar
Koura, M., Gaber, A., Meguid, M. A. & Saif, M. (1975). Treatment of intestinal biharziasis with oral oxamniquine (a preliminary report). Journal of the Egyptian Medical Association 58, 287–95.Google Scholar
Lennox, R. W. & Schiller, E. L. (1972). Changes in dry weight and glycogen content as criteria for measuring the postcercarial growth and development of Schistosoma mansoni. Journal of Parasitology 58, 489–94.CrossRefGoogle ScholarPubMed
Prata, A., Figueiredo, J. F. M., Brandt, P. C. & Lavria, L. (1973). Oxamniquine given in a single intramuscular dose for the treatment of Schistosoma mansoni infection. Revista do Instituto de Medicina Tropical de Sao Paulo 15 (Suppl. 1), 47–57.Google Scholar
Silva, L. C. Da, Sette, H. Jr, Chamone, D. A. F., Alquezar, S. A., Punskas, J. A. & Raia, S. (1974). Clinical trials with oral oxamniquine (UK-4271) for the treatment of mansonian schistosomiasis. Revista do Instituto de Medicina Tropical de Sao Paulo 167, 103–9.Google Scholar
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Woolhouse, N. M. & Wood, P. R. (1976). The determination of oxamniquine in serum. Jounral of Pharmaceutical Sciences (in the Press).Google Scholar