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A systematic review of anti-Entamoeba histolytica activity of medicinal plants published in the last 20 years

Published online by Cambridge University Press:  04 February 2021

Saeed Nezaratizade Open the ORCID record for Saeed Nezaratizade [Opens in a new window] ,
Nooshin Hashemi Open the ORCID record for Nooshin Hashemi [Opens in a new window] ,
Davood Ommi Open the ORCID record for Davood Ommi [Opens in a new window] ,
Ilkay Erdogan Orhan Open the ORCID record for Ilkay Erdogan Orhan [Opens in a new window]  and
Faham Khamesipour Open the ORCID record for Faham Khamesipour [Opens in a new window]
Saeed Nezaratizade
Affiliation:
Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Nooshin Hashemi
Affiliation:
School of Medicine, Bam University of Medical Sciences, Bam, Iran
Davood Ommi
Affiliation:
Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ilkay Erdogan Orhan
Affiliation:
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Faham Khamesipour*
Affiliation:
Shahid Beheshti University of Medical Sciences, Tehran, Iran
*
Author for correspondence: Faham Khamesipour, E-mail: [email protected]
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Abstract

Amoebiasis has emerged as a major health problem worldwide. It is endemic in the present scenario is different and sub-tropical regions especially in Asia, Latin America and also in Africa. Causative of amoebiasis is a protozoan known as Entamoeba histolytica. We screened all the databases such as PubMed, Science Direct, Medline and Google Scholar by using the keywords ‘anti-Entamoeba histolytica activity of medicinal plants, anti-Entamoeba histolytica activity of herbal drugs, the anti-amoebic activity of natural drugs’. In the present study, we found 7861 articles, where all articles were screened for bias analysis and included 32 full-matching articles in total reporting the use of medicinal plants as a remedy for amoebiasis. Through these articles, we found 42 herbs having anti-amoebic activity. In bias analysis, we also found four articles under high bias risk. In our study, seven medicinal plants were concluded to possess the most potent anti-amoebic activity based on their IC50 value, which was less than 1 μg mL−1. On bias analysis, we found four articles with high bias risk, hence these studies can be repeated for better results.

Keywords

Anti-amoebic activityanti-Entamoeba histolytica activitymedicinal plantsPRISMA
Type
Review Article
Information
Parasitology , Volume 148 , Issue 6 , May 2021 , pp. 672 - 684
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Copyright
Copyright © The Author(s) 2021. Published by Cambridge University Press

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