Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-26T18:34:37.344Z Has data issue: false hasContentIssue false
  • English
  • Français

Suppression of expulsion of Aspiculuris tetraptera in hydrocortisone and methotrexate treated mice

Published online by Cambridge University Press:  06 April 2009

Jerzy M. Behnke
Jerzy M. Behnke
Affiliation:
Zoology Department, Bedford College, University of London, Regent's Park, London, N. W. 1
Get access Rights & Permissions [Opens in a new window]

Extract

Hydrocortisone treated male and female mice, given a primary infection with Aspiculuris tetraptera, did not reject the worms during the third week of infection. Mice given hydrocortisone during the first week of infection had elevated worm burdens on day 10, suggesting that some worm loss was encountered during the anterior migration in control mice. Furthermore, this temporary period of treatment was sufficient totally to suppress rejection and to allow the parasite to persist until day 28. Methotrexate also significantly delayed rejection, but larval growth was retarded in treated mice. These results, it is suggested, add strength to the hypothesis that the loss of A. tetraptera in a primary infection in mice, is an immunological phenomenon.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 1 , August 1975 , pp. 109 - 116
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anya, A. O. (1966). Studies on the biology of some oxyurid nematodes. II. The hatching of eggs and development of Aspiculuris tetraptera Schultz within the host. Journal of Helminthology 40, 261–8.CrossRefGoogle Scholar
Behnke, J. M. (1974 a). The biology of Aspiculuris tetraptera Schultz (Nematoda, Oxyuroidea). Ph.D. Thesis, University of London.Google Scholar
Behnke, J. M. (1974 b). The distribution of larval Aspiculuris tetraptera Schultz during a primary infection in Mus musculus, Rattus norvegicus and Apodemus sylvaticus. Parasitology 69, 391–402.Google Scholar
Behnke, J. M. (1975). Immune expulsion of the nematode Aspiculuris tetraptera from mice given primary and challenge infections. International Journal for Parasitology (in the Press).Google Scholar
Berenbaum, M. C. (1963). Prolongation of homograft survival in guinea pigs treated with amethopterin. Nature, London 198, 606–7.CrossRefGoogle ScholarPubMed
Bishop, O. N. (1971). Statistics for Biology. 2nd ed. Longman.Google Scholar
Coker, C. M. (1955). Effects of cortisone on Trichinella spiralis infections in non-immunized mice. Journal of Parasitology 41, 498–504.Google Scholar
Cohen, J. J. (1971). The effects of hydrocortisone on the immune response. Annals of Allergy 29, 358–61.Google ScholarPubMed
Cohen, J. J. & Claman, H. N. (1971). Thymus marrow immunocompetence. V. Hydrocortisone resistant cells and processes in the haemolytic antibody response of mice. Journal of Experimental Medicine 133, 1026–34.CrossRefGoogle ScholarPubMed
Cohen, J. J., Fischbach, M. & Clanan, H. N. (1970). Hydrocortisone resistance of graft vs. host activity in mouse thymus, spleen and bone marrow. Immunology 105, 1146–50.Google ScholarPubMed
Dineen, J. K. & Adams, D. B. (1971). The role of the recirculating thymus-dependant lymphocyte in resistance to Trichostrongylus colubriformis in the guinea pig. Immunology 20, 109–13.Google Scholar
Dineen, J. K. & Kelly, J. D. (1973). Expulsion of Nippostrongylus brasiliensis from the intestine of rats. The role of a cellular componeut derived from bone marrow. International Archives of Allergy and Applied Immunology 45, 759–66.CrossRefGoogle ScholarPubMed
Dineen, J. K., Kelly, J. D., Goodrich, B. S. & Smith, I. D. (1974). Expulsion of Nippostrongylus brasiliensis from the small intestine of the rat by prostaglandin-like factors from ram semen. International Archives of Allergy and Applied Immunology 40, 360–74.Google Scholar
DiNetta, J., Katz, F. & Campbell, W. C. (1972). Effect of heterologous antilymphocyte serum on the spontaneous cure of Trichinella spiralis infections in mice. Journal of Parasitology 58, 636–7.CrossRefGoogle ScholarPubMed
Friedman, R. M. (1964). Inhibition of established tuberculin hypersensitivity by methotrexate. Proceedings of the Society for Experimental Biology and Medicine 116, 471–5.CrossRefGoogle ScholarPubMed
Friedman, R. M., Buckler, C. E. & Baron, S. (1961). The effect of aminomethylpteroylglutamic acid on the development of skin hypersensitivity and on antibody formation in guinea pigs. Journal of Experimental Medicine 114, 173–83.CrossRefGoogle ScholarPubMed
Hopkins, C. A., Subramanian, G. & Stallard, H. (1972). The effect of immunosuppressants on the development of Hymenolepis diminuta in mice. Parasitology 65, 111–20.CrossRefGoogle ScholarPubMed
Many, A. & Schwartz, R. S. (1970). On the mechanism of immunological tolerance in cyclophosphamide-treated mice. Clinical and Experimental Immunology 6, 87–99.Google ScholarPubMed
Mathies, A. W. (1959). Certain aspects of the host-parasite relationship of Aspiculuris tetraptera, a mouse pinworm. II. Sex resistance. Experimental Parasitology 8, 39–45.CrossRefGoogle ScholarPubMed
Matheies, A. W. (1962). Certain aspects of the host-parasite relationship of Aspiculuris tetraptera, a mouse pinworm. III. Effect of cortisone. Journal of Parasitology 48, 244–8.Google Scholar
North, R. J. (1972). The action of cortisone on cell-mediated immunity to infection: histogenesis of the lymphoid cell response and selective elimination of committed lymphocytes. Cellular Immunology 3, 501–15.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. (1965). Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts. Parasitology 55, 723–30.CrossRefGoogle Scholar
Ogilvie, B. M. & Jones, V. E. (1967). Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. I. The effect of thymectomy, neonatal infections and splenectomy. Parasitology 57, 335–49.Google Scholar
Ogilvie, B. M. & Jones, V. E. (1971). Nippostrongylus brasiliensis: a review of immunity and the host/parasite relationship in the rat. Experimental Parasitology 29, 138–77.Google Scholar
Ogilvie, B. M. & Jones, V. E. (1973). Immunity in the parasitic relationship between helminths and hosts. Progress in Allergy 17, 93–144.Google Scholar
Olivier, L. (1962). Studies on natural resistance to Taenia taenaeformis in mice. II. The effect of cortisone. Journal of Parasitology 48, 758–62.CrossRefGoogle ScholarPubMed
Ritterson, A. L. (1968). Effect of immunosuppressive drugs (6 mercaptopurine and methotrexate) on the resistance of Chinese hamsters to the tissue phase of Trichinella spiralis. Journal of Infectious Diseases 118, 365–9.CrossRefGoogle Scholar
Smith, I. D., Goodrich, B. S., Kelly, J. D. & Dineen, J. K. (1974). Prostaglandin-like activity of various fractions of ram semen: their role in the immune rejection of the nematode Nippostrongylus brasiliensis from the small intestine of rats. Prostaglandins 5, 87–96.Google Scholar
Sokal, R. R. & Rohlf, F. J. (1969). Biometry. San Francisco: W. H. Freeman & Co.Google Scholar
Stahl, W. (1961). Influences of age and sex on susceptibility of albino mice to infection with Aspiculuris tetraptera. Journal of Parasitology 47, 939–41.CrossRefGoogle ScholarPubMed
Stahl, W. (1966). Experimental Aspiculuriasis. I. Resistance to superinfection. Experimental Parasitology 18, 109–15.Google Scholar
Wakelin, D. (1970). Studies on the immunity of albino mice to Trichuris muris. Suppression of immunity by cortisone acetate. Parasitology 60, 229–37.Google Scholar
Wakelin, D. & Selby, G. R. (1974). The induction of immunological tolerance to the parasitic nematode Trichuris muris in cortisone treated mice. Immunology 26, 1–10.Google Scholar
Wilson, J. M. (1971). Effect of methotrexate on the parasitic development of the nematode Dictyocaulus viviparus (Metastrongylidae), and on the immune response of infected guinea-pigs. Parasitology 63, 145–56.Google Scholar