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Studies on immunity to Haemonchus contortus infection: the elimination of a challenge infection by immune sheep

Published online by Cambridge University Press:  06 April 2009

P. K. Bitakaramire
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow

Extract

Ten-month-old Blackface sheep double vaccinated with X-irradiated larvae of H. contortus were shown to be highly resistent to individual challenge with 50000 larvae. Compared to unvaccinated sheep, the percentage reductions in the numbers of worms established 6, 9, 12 and 16 days after challenge were 83, 90, 99 and 100 respectively. The immune response was directed against the 3rd and 4th larval stages.

The author wishes to express his thanks to his colleagues at the Wellcome Laboratories for Experimental Parasitology for their co-operation and help during the period of this experiment.

This work was supported by a grant from Allen and Hanburys Ltd., Ware, England.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1966

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References

REFERENCES

Jarrett, W. F. H., Jennings, F. W., McIntyre, W. I. M., Mulligan, W. & Sharp, N. C. C. (1959). Studies on immunity to Haemonchus contortus infection—vaccination of sheep using a single dose of X-irradiated larvae. Am. J. vet. Res. 20, 527–31.Google Scholar
Jarrett, W. F. H., Jennings, F. W., Mointyre, W. I. M., Mulligan, W. & Sharp, N. C. C. (1961). Studies on immunity to Haemonchus contortus infection—double vaccination of sheep with irradiated larvae. Am. J. vet. Res. 22, 186–8.Google ScholarPubMed
Jennings, F. W., Mulligan, W. & Urquhart, G. M. (1963). Variables in X-ray ‘Inactivation’ of Nippostrongylus brasiliensis larvae. Expl Parasit. 13, 367–73.CrossRefGoogle ScholarPubMed
Ross, J. G. (1963). The role of the larval stages of Haemonchus placei infections of cattle in immunity. J. Helminth. 37, 359–68.CrossRefGoogle ScholarPubMed
Silverman, P. H. & Patterson, J. E. (1960). Histotrophic (parasitic) stages of Haemonchus contortus. Nature, Lond. 185, 54–5.CrossRefGoogle ScholarPubMed
Urquhart, G. M., Jarrett, W. F. H., Jennings, F. W., McIntyre, W. I. M., Mulligan, W. & Sharp, N. C. C. (1966). Studies on immunity to Haemonchus contortus infection—failure of X-irradiated larvae to immunize young lambs. Am. J. vet. Res. (In the Press).Google Scholar
Urquhart, G. M., Jarrett, W. F. H., & Mulligan, W. (1962). Helminth immunity. Adv. vet. Sci. 7, 87129.Google Scholar