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Structural changes in the bovine nematode Haemonchus placei, that may be associated with host immune response

Published online by Cambridge University Press:  06 April 2009

E. Harness ,
K. Smith  and
Patricia Bland
E. Harness
Affiliation:
Institute for Research on Animal Diseases, Compton, Nr Newbury, Berks.
K. Smith
Affiliation:
Institute for Research on Animal Diseases, Compton, Nr Newbury, Berks.
Patricia Bland
Affiliation:
Institute for Research on Animal Diseases, Compton, Nr Newbury, Berks.
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Extract

The structure of H. placei adult worms, obtained from calves at 4, 7, 10 or 11–13 weeks after primary infection, has been studied. A reorganization of rough endoplasmic reticuhim in the cytoplasm of the gut cells was seen at 10 weeks and this was followed by marked vacuolation of many of these cells, associated with an increase in lipid production. Increases of lipid were also found in the hypodermis, lateral cords and occasionally muscle cells of worms examined at 11–13 weeks after infection.

It is suggested that these changes are the result of the host immune response, because they resemble changes which occur in the rat nematode Nippostrongylus brasiliensis and which are known to be caused by host immunity.

Type
Research Article
Information
Parasitology , Volume 66 , Issue 1 , February 1973 , pp. 199 - 205
Copyright
Copyright © Cambridge University Press 1973

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References

Harness, E., Sellwood, S. A., & Young, E. R., (1971). Experimental Haemonchus placei infection in calves: influence of anaemia and numbers of larvae on worm development. Journal of Comparative Pathology 81, 129–36.CrossRefGoogle ScholarPubMed
Lee, D. L., (1969). Changes in adult Nippostrongylus brasiliensis during the development of immunity to this nematode in rats. I. Changes in ultrastructure. Parasitology 59, 29–39.CrossRefGoogle Scholar
Lee, D. L., (1971). Changes in adult Nippostrongylus brasiliensis during the development of immunity to this nematode. II. Total lipids and neutral lipids. Parasitology 63, 271–4.CrossRefGoogle Scholar
Millonig, G., (1961). Advantage of a phosphate buffer for osmium tetroxide solutions in fixation. Journal of Applied Physics 32, 1637.Google Scholar
Ogilvie, B. M., & Hockley, D. J., (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.CrossRefGoogle ScholarPubMed
Ogilvie, B. M., & Jones, V. E., (1971). Nippostrongylus brasiliensis: A review of immunity and the host/parasite relationship in the rat. Experimental Parasitology 29, 138–77.CrossRefGoogle ScholarPubMed
Sabatini, D. D., Bensch, K., & Barnett, R. J., (1963). Cytochemistry and electron microscopy. The presentation of cellular ultrastructure and enzymatic activity by aldehyde fixation. Journal of Cell Biology 17, 19–58.CrossRefGoogle Scholar
Smith, K., & Harness, E., (1972). The ultrastructure of the adult stage of Trichostrongylus colubriformis and Haemonchus placei. Parasitology 64, 173–9.CrossRefGoogle ScholarPubMed
Taliaferro, W. H., & Sarles, M. P., (1939). The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus muris. Journal of Infectious Diseases 64, 157–92.CrossRefGoogle Scholar
Venable, J. H., & Coggeshall, R., (1965). A simplified lead citrate stain for use in electron microscopy. Journal of Cell Biology 25, 407–8.CrossRefGoogle ScholarPubMed
Wright, K. A., & Jones, N. O., (1965). Some techniques for the orientation and embedding of nematodes for electron microscopy. Nematologica 11, 125–30.Google Scholar