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Some general characteristics of the transport of nutrients and toxic compounds in yeasts and fungi

Published online by Cambridge University Press:  23 August 2011

A. A. Eddy
A. A. Eddy
Affiliation:
Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester M60 1QD
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Extract

This essay deals in turn with the six main mechanisms that are believed to be involved in the passage of small molecules across the cell membrane of yeasts and fungi. Such solutes include amino acids, carbohydrates, purines and pyrimidines and other nutrients, among which are the ions K+, , or . The subject has been reviewed extensively (see, for example, Eddy, 1982; Cooper, 1982; Serrano, 1984; Harold, 1986). Transport systems relate to chemotherapy in two ways. First, they may themselves be potential targets for drug action. Second, they may deliver a drug to its intracellular target, the drug being an illicit passenger in a transport system with a different primary role. Most of our knowledge about yeast and fungal transport is currently based on studies with relatively few species selected because they are known to be amenable to genetic and biochemical analysis. The organisms include representative strains of Neurospora crassa or of Saccharomyces cerevisiae and selected species of Rhodotorula and Schizosaccharomyces. Fungal organisms pathogenic to man, such as Candida albicans, those causing either systemic fungal infections (see Kerridge, 1986; Shepherd, Poulter & Sullivan, 1985), or the numerous fungal diseases of plants have been little used as models of nutrient transport, despite their clinical or economic importance. Whether all these ecologically diverse organisms, which in evolutionary terms are only distantly related, employ only the transport mechanisms so far discovered in Saccharomyces cerevisiae is an open question.

Type
Research Article
Information
Parasitology , Volume 96 , supplement S1: Symposia of the British Society for Parasitology Volume 25 Molecular transfer across parasite membranes , January 1988 , pp. S45 - S56
Copyright
Copyright © Cambridge University Press 1988

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