Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-12-02T21:40:22.998Z Has data issue: false hasContentIssue false
  • English
  • Français

Sensory basis of activity in Ancylostoma tubaeforme infective larvae

Published online by Cambridge University Press:  06 April 2009

Neil A. Croll  and
Ismail Al-Hadithi
Neil A. Croll
Affiliation:
Department of Zoology and Applied Entomology, Imperial College, London University, London, S. W. 7
Ismail Al-Hadithi
Affiliation:
Department of Zoology and Applied Entomology, Imperial College, London University, London, S. W. 7
Get access Rights & Permissions [Opens in a new window]

Extract

Upon stimulation, following a period of ambient conditions, infective A. tubaeforme larvae follow a committed characteristic pattern of activity, after being released by short-term mechanical or continuous photic stimulation. For the photic response this is stimulated by an increase in the intensity of stimulation, and for non-dark-adapted larvae a sudden fivefold increase in illumination is required, irrespective of previous stimulation.

Acetylcholine chloride, adenosine triphosphate, γ-amino butyric acid, histamine diphosphate, 5-hydroxytryptamine, neostigmine bromide, physostigmine (eserine), potassium hydroxide, succinyl choline chloride and d-tubocurarine chloride have been added to larvae and their subsequent postures and activity recorded. It is concluded that the typical activity pattern of larvae may be altered by the use of drugs which interfere with neuromuscular phenomena, and therefore the activity responses of infective A. tubaeforme are based on sensory and neurosecretory rather than energetic considerations.

We thank Mrs Helen Foreman for maintaining the larvae and the Medical Research Council of Great Britain for their generous support.

Type
Research Article
Information
Parasitology , Volume 64 , Issue 2 , April 1972 , pp. 279 - 291
Copyright
Copyright © Cambridge University Press 1972

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Baldwin, E. & Moyle, V. (1949). A contribution to the physiology and pharmacology of Ascaris lumbricoides from the pig. British Journal of Pharmacology 4, 145–52.Google Scholar
Barrett, J. (1969). The effect of ageing on the metabolism of the infective larvae of Strongyloides ratti, Sandground, 1925. Parasitology 59, 3–17.CrossRefGoogle Scholar
Bishop, D. W. (1958). Motility of the sperm flagellum. Nature 182, 1638–40.CrossRefGoogle ScholarPubMed
Broome, A. W. J. (1961). Studies on the mode of action of methyridine. British Journal of Pharmacology 17, 327–38.Google ScholarPubMed
Castillo, J. C. & de Beer, E. J. (1950). The neuromuscular blocking agents action of succinylcholine chloride (diacetylcholine). Journal of Pharmacology and Experimental Therapeutics, 99, 458–64.Google ScholarPubMed
Croll, N. A. (1965). The klinokinetic behaviour of infective Trichonema larvae in light. Parasitology 55, 579–82.CrossRefGoogle Scholar
Croll, N. A. (1966). Activity and the orthokinetic response of larval Trichonema to light. Parasitology 56, 307–12.CrossRefGoogle ScholarPubMed
Croll, N. A. (1970 a). Sensory basis of activation in nematodes. Experimental Parasitology 27, 350–6.CrossRefGoogle ScholarPubMed
Croll, N. A. (1970 b). Behaviour of Nematodes: Their Senses and Responses. London: Edward Arnold.Google Scholar
Croll, N. A. (1972). Energy utilization of infective Ancylostoma tubaeforme larvae. Parasitology (in the Press).Google ScholarPubMed
Davey, K. G. (1967). Endocrine basis for ecdysis in a parasitic nematoda. Nature 214, 737–8.CrossRefGoogle Scholar
Del Castillo, J. (1969). Pharmacology of nematodes. In Chemical Zoology, vol. 3 (ed. Florkin, M. and Scheer, B. T.). London: Academic Press.Google Scholar
Del Castillo, J. & Morales, T. (1969). Electrophysiological experiments in Ascaris lumbricoides. In Experiments in Physiology and Biochemistry, vol. 2 (ed. Kerkut, G. A.). London: Academic Press.Google Scholar
Denham, D. A. (1971). Ostertagia circumcincta: methyridine and tetromisole against third-stage larvae. Experimental Parasitology 28, 493–8.CrossRefGoogle Scholar
Fiakpui, Z. (1967). Some effects of piperazine and methyridine on the free-living nematode, Caenorhabditis briggsae (Rhabditidae). Nematologica 13, 241–55.CrossRefGoogle Scholar
Glochin, V. C. & Fairbairn, D. (1952). The metabolism of Heterakis gallinae. 1. Aerobic and anaerobic respiration: carbohydrate sparing action of carbon dioxide. Journal of Cellular and Comparative Physiology 39, 341–56.CrossRefGoogle Scholar
Goodman, L. G. & Gilman, A. (1955). The Pharmacological Basis of Therapeutics, 2nd ed. New York: Macmillan.Google Scholar
Goodwin, L. C. & Vaughan, E. M. Williams (1963). Inhibition and neuromuscular paralysis in Ascaris lumbricoides. Journal of Physiology 168, 857–971.CrossRefGoogle ScholarPubMed
Hinks, C. F. (1967). Relationship between serotonin and the circadian rhythm in some nocturnal moths. Nature 214, 386–7.CrossRefGoogle ScholarPubMed
Lee, D. L. (1966). An electron microscope study of the body wall of the third-stage larva of Nippostrongylus brasiliensis. Parasitology 56, 127–35.CrossRefGoogle ScholarPubMed
Rosenbluth, J. (1963). Fine structure of body muscle cells and neuro-muscular junctions in Ascaris lumbricoides. Journal of Cell Biology 19, 82A (Abstr).Google Scholar
Rosenbluth, J. (1965). Ultrastructure of somatic muscle cells in Ascaris lumbricoides. II. Intermuscular junctions, neuromuscular junctions and glycogen stores. Journal of Cell Biology 26, 579–91.CrossRefGoogle ScholarPubMed