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The schistosome in the mammalian host: understanding the mechanisms of adaptation

Published online by Cambridge University Press:  18 June 2007

J. R. KUSEL*
Affiliation:
Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
B. H. AL-ADHAMI
Affiliation:
Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
M. J. DOENHOFF
Affiliation:
School of Biological Sciences, University of Wales, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK
*
*Corresponding author: Glasgow Biomedical Research Centre, 120 University Place, GlasgowG12 8TA, UK. Tel: 0141 330 5471. Fax: 0141 330 4600. E-mail: [email protected]

Summary

In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs of the parasite, with host fluids and cells. The surface and secretions of the schistosome egg have very different properties from those of other parasite stages, but adapted for the dispersal of the eggs and for the preservation of host liver function. We draw from studies of mammalian cells and other organisms to indicate how further work might be carried out on the signalling function of the surface glycocalyx, the raft structure of the surface and existence of pores in the surface membrane, the repair of the surface membrane, the role of the membrane structure in ion channel function (including recent work on the actin cytoskeleton and calcium channels) and the possible role of P-glycoproteins in the adaptation of the parasite to its environment. We are speculative in some areas, such as the suggestions that variability in surface properties of schistosomes may relate to the existence of membrane rafts and that parasite communities may exhibit quorum sensing. This speculative approach is adopted with the hope that future work on the whole organisms and their interactions will be encouraged.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2007

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References

REFERENCES

Agnew, A. M., Murare, H. M. and Doenhoff, M. J. (1993). Immune attrition of adult schistosomes. Parasite Immunology 15, 261271.CrossRefGoogle ScholarPubMed
Al-Adhami, B. H., Doenhoff, M., Thornhill, J. A., Akhkha, A., White, E. and Kusel, J. R. (2001). A study of some characteristics of individual clones of Schistosoma mansoni with emphasis on biological and metabolic activities. Parasitology 123, 563572.CrossRefGoogle ScholarPubMed
Al-Adhami, B. H., Noble, C., Sharaf, O., Thornhill, J., Doenhoff, M. and Kusel, J. R. (2005). The role of acidic organelles in the development of schistosomula of Schistosoma mansoni and their response to signalling molecules. Parasitology 130, 309322.CrossRefGoogle ScholarPubMed
Albi, E., Peloso, I. and Magni, M. V. (1999). Nuclear membrane sphingomyelin-cholesterol changes in rat liver after hepatectomy. Biochemical and Biophysical Research Communications 262, 692695.CrossRefGoogle ScholarPubMed
Allan, D., Payares, G. and Evans, W. H. (1987). The phospholipids and fatty acid composition of Schistosoma mansoni and its purified tegumental membranes. Molecular and Biochemical Parasitology 23, 123128.CrossRefGoogle ScholarPubMed
Amiri, P., Locksley, R. M., Parslow, T. G., Sadick, M., Rector, E., Ritter, D. and McKerrow, J. H. (1992). Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature, London 356, 604607.CrossRefGoogle ScholarPubMed
Andrade, Z. A. and Warren, K. S. (1964). Mild prolonged schistosomiasis in mice: alterations on host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 58, 5357.CrossRefGoogle ScholarPubMed
Angeli, V., Faveeuw, C., Roye, O., Fontaine, J., Tessier, E., Capron, A., Wolowczuk, I., Capron, M. and Trottein, F. (2001). Role of parasite derived prostaglandin D-2 in the inhibition of epidermal cell migration during schistosomiasis infection. Journal of Experimental Medicine 193, 11351147.CrossRefGoogle Scholar
Angelucci, F., Johnson, K. A., Baiocco, P., Miele, A. E., Brunori, M., Valle, C., Vigorosi, F., Troiani, A. R., Liberti, P., Cioli, D., Klinkert, M.-Q. and Bellelli, A. (2004). Schistosoma mansoni fatty acid binding protein. Specificity and functional control as revealed by crystallographic structure. Biochemistry 43, 1300013011.CrossRefGoogle ScholarPubMed
Appelmelk, B. J., Monteiro, M. A., Martin, S. L., Moran, A. P. and Vandenbroucke-Grauls, C. M. (2000). Why Helicobacter pylori has Lewis antigens. Trends in Microbiology 8, 565570.CrossRefGoogle ScholarPubMed
Apps, D. K., Percy, J. M. and Perez-Castineir, J. R. (1989). Topography of a vacuolar-type H+-translocating ATPase: chromaffin-granule membrane ATPase. The Biochemical Journal 263, 8188.CrossRefGoogle ScholarPubMed
Asahi, H. and Stadecker, M. J. (2003). Analysis of egg antigens inducing hepatic lesions in schistosome infection. Parasitology International 52, 361367.CrossRefGoogle ScholarPubMed
Ashton, P. D., Harrop, R., Shah, B. and Wilson, R. A. (2001). The schistosome egg: development and secretions. Parasitology 122, 329338.CrossRefGoogle ScholarPubMed
Aspinall, G. O., Monteiro, M. A., Shaver, R. T., Kurjanczyk, L. A. and Penner, J. L. (1997). Lipopolysaccharides of Helicobacter pylori serogroups O:3 and O:6–structures of a class of lipopolysaccharides with reference to the location of oligomeric units of D-glycero-alpha-D-manno-heptose residues. European Journal of Biochemistry 248, 592601.CrossRefGoogle Scholar
Bahgat, M., Franklow, K., Doenhoff, M. J., Li, Y. L., Ramzy, R. M., Kirsten, C. and Ruppel, A. (2001). Infection induces antibodies against the cercarial secretions, but not against the cercarial elastases of Schistosoma mansoni, Schistosoma heamatobium, Schistosoma japonicum, and Trichobilharzia ocellata. Parasite Immunology 23, 557565.CrossRefGoogle ScholarPubMed
Bahia, D., Mortara, R. A., Kusel, J. R., Andrade, L. F., Ludolf, F., Kuser, P. R., Avelar, L., Trolet, J., Dissous, C., Pierce, R. J. and Oliveira, G. (2007). Schistosoma mansoni: Expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration. Experimental Parasitology 116, 225232.CrossRefGoogle ScholarPubMed
Baptista, A. P. and Andrade, Z. A. (2005). Angiogenesis and schistosomal granuloma formation. Memorias do Instituto Oswaldo Cruz 100, 183185.CrossRefGoogle ScholarPubMed
Bàthori, G., Parolini, I., Tombola, F., Szabò, I., Messina, I., Oliva, M., De Pinto, V., Lisanti, M., Sargiacomo, M. and Zoratti, M. (1999). Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. Journal of Biological Chemistry 274, 2960729612.CrossRefGoogle ScholarPubMed
Bayne, C. J. and Grevelding, C. G. (2003). Cloning of Schistosoma mansoni sporocysts in vitro and detection of genetic heterogeneity among individuals within clones. Journal of Parasitology 89, 10561060.CrossRefGoogle ScholarPubMed
Beguin, P., Mahalakshmi, R. N., Nagashima, K., Cher, D. H., Takahashi, A., Yamada, Y., Seino, Y. and Hunziker, W. (2005). 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity. Journal of Cell Science 118, 19231934.CrossRefGoogle ScholarPubMed
Bergwerff, A. A., VanDam, G. J., Rotmans, J. P., Deelder, A. M., Kamerling, J. P. and Vliegenthart, J. F. G. (1994). The immunologically reactive part of immunopurified circulating anodic antigen from Schistosoma mansoni is a threonine-linked polysaccharide consisting of→6)-(beta-D-GlcpA-(1→3))-beta-D-GalpNAc-(1→repeating units. Journal of Biological Chemistry 269, 3151031517.CrossRefGoogle Scholar
Billah, M. M. (1993). Phospholipase D and cell signaling. Current Opinion in Immunology 5, 114123.CrossRefGoogle ScholarPubMed
Blanton, R. E., Licate, R. S. and Aman, R. A. (1994). Characterisation of a native and recombinant S. haematobium serine protease inhibitor gene product. Molecular and Biochemical Parasitology 63, 111.CrossRefGoogle ScholarPubMed
Blobel, C. P. (2002). Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding. Inflammation Research 51, 8384.CrossRefGoogle Scholar
Bogers, J. J., Nibbeling, H. A., van Marck, E. A. and Deelder, A. M. (1994). Immunofluorescent visualisation of the excretory and gut system of Schistosoma mansoni by confocal laser scanning microscopy. American Journal of Tropical Medicine and Hygiene 50, 612619.CrossRefGoogle ScholarPubMed
Bogitsch, B. J. (1975). Cytochemistry of gastrodermal autophagy following starvation in Schistosoma mansoni. Journal of Parasitology 61, 237248.CrossRefGoogle Scholar
Bohana-Kashtan, O., Ziporen, L., Donin, N., Kraus, S. and Fishelson, Z. (2004). Cell signals transduced by complement. Molecular Immunology 41, 583597.CrossRefGoogle ScholarPubMed
Boros, D. L., Pelley, R. P. and Warren, K. S. (1975). Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni. Journal of Immunology 114, 14371441.CrossRefGoogle ScholarPubMed
Borst, P., Zelcer, N. and van Helvoort, A. (2000). ABC transporters in lipid transport. Biochimica et Biophysica Acta 1486, 128144.CrossRefGoogle ScholarPubMed
Bosch, I. B., Wang, Z. X., Tao, L. F. and Shoemaker, C. B. (1994). Two Schistosoma mansoni cDNA's encoding ATP-binding cassette (ABC) family proteins. Molecular and Biochemical Parasitology 65, 351356.CrossRefGoogle ScholarPubMed
Bostic, J. R. and Strand, M. (1996). Molecular cloning of a Schistosoma mansoni protein expressed in the gynecophoral canal of male worms. Molecular and Biochemical Parasitology 79, 7989.CrossRefGoogle ScholarPubMed
Boyle, J. P. and Yoshino, T. P. (2003). Gene manipulation in parasitic helminths. International Journal for Parasitology 33, 12591268.CrossRefGoogle ScholarPubMed
Braccia, A., Villani, M., Immerdal, L., Niels-Christiansen, L. L., Nystrom, B. T., Hansen, G. H. and Danielsen, E. M. (2003). Microvillar membrane microdomains exist at physiological temperature. Role of galectin-4 as lipid raft stabilizer revealed by “superrafts”. Journal of Biological Chemistry 278, 1567915684.CrossRefGoogle ScholarPubMed
Braschi, S., Curwen, R., Ashton, P., Verjovski-Almeida, S. and Wilson, R. A. (2006). The tegumental surface membranes of the human parasite Schistosoma mansoni: a proteomic analysis after differential extraction. Proteomics 6, 14711482.CrossRefGoogle Scholar
Braschi, S. and Wilson, R. A. (2006). Proteins exposed at the adult schistosome surface revealed by biotinylation. Molecular and Cellular Proteonomics 5, 347356.CrossRefGoogle ScholarPubMed
Breternitz, R., Kusel, J. R., Lutz, F., Buehrle, C. and Ruppel, A. (1992). Schistosoma mansoni: stage-dependent formation and repair of membrane pores induced by a cytotoxin from Pseudomonas aeruginosa. Experimental Parasitology 74, 340347.CrossRefGoogle ScholarPubMed
Bricker, C. S., Pax, R. A. and Bennett, J. L. (1982). Microelectrode studies of the tegument, subtegumental compartments of male Schistosoma mansoni: anatomical sources of electric potential. Parasitology 85, 149161.CrossRefGoogle Scholar
Brouwers, J. F. H. M., Skelly, P. J., Van Golde, L. M. G. and Tielens, A. G. M. (1999). Studies on phospholipids argue against sloughing of tegumental membranes in adult Schistosoma mansoni. Parasitology 119, 287294.CrossRefGoogle ScholarPubMed
Brouwers, J. F. H. M., Versluis, C., Van Golde, L. M. G. and Tielens, A. G. M. (1998). 5-Octadecenoic acid: new evidence for a novel type of fatty acid modification in schistosomes. The Biochemical Journal 334, 315319.CrossRefGoogle Scholar
Brown, D. A. (2001). Seeing is believing: visualization of rafts in model membranes. Proceedings of the National Academy of Sciences, USA 98, 1051710518.CrossRefGoogle ScholarPubMed
Brown, S. P. and Grenfell, B. T. (2001). An unlikely partnership: parasites, concomitant immunity and host defence. Proceedings of the Royal Society of London, B 268, 25432549.CrossRefGoogle ScholarPubMed
Brownlee, D. J., Fairweather, I. and Johnston, C. F. (1993). Immunocytochemical demonstration of neuropeptides in the peripheral nervous system of the roundworm Ascaris suum (Nematoda, Ascaroidea). Parasitology Research 79, 302308.CrossRefGoogle ScholarPubMed
Brunet, L. R., Beall, M., Dunne, D. W. and Pearce, E. J. (1999). Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection. Journal of Immunology 163, 49764984.CrossRefGoogle ScholarPubMed
Brunet, L. R., Finkelman, F. D., Cheever, A. W., Kopf, M. A. and Pearce, E. J. (1997). IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. Journal of Immunology 159, 777785.CrossRefGoogle ScholarPubMed
Byram, J. E., Doenhoff, M. J., Musallam, R., Brink, L. H. and Von Lichtenberg, F. (1979). Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. II. Pathology. American Journal of Tropical Medicine and Hygiene 28, 274285.CrossRefGoogle ScholarPubMed
Byram, J. E. and Von Lichtenberg, F. (1977). Altered schistosome granuloma formation in nude mice. American Journal of Tropical Medicine and Hygiene 26, 944956.CrossRefGoogle ScholarPubMed
Capron, A., Riveau, G., Capron, M. and Trottein, F. (2005). Schistosomes: the road from host-parasite interactions to vaccines in clinical trials. Trends in Parasitology 21, 143149.CrossRefGoogle ScholarPubMed
Capron, M., Carlier, Y., Nzeyimana, H., Minoprio, P., Santoro, F., Sellin, B. and Capron, A. (1980). In vitro study of immunological events in human and experimental schistosomiasis: relationships between cytotoxic antibodies and circulating Schistosoma antigens. Parasite Immunology 2, 223235.CrossRefGoogle ScholarPubMed
Carvalho, M. G., Mello, R. T., Soares, A. L., Bicalho, R. S., Lima e, Silva F. C. and Coelho, P. M. (2005). Murine schistosomiasis mansoni: process of blood coagulation at pre-patent, acute and chronic phases, and consequence of chemotherapeutic cure on the reversion of changes. Blood Coagulation and Fibrinolysis 16, 469475.CrossRefGoogle ScholarPubMed
Carvalho, W. S., Lopes, C. T., Juliano, L., Coelho, P. M., Cunha-Melo, J. R., Beraldo, W. T. and Pesquero, J. L. (1998). Purification and partial characterization of kininogenase activity from Schistosoma mansoni adult worms. Parasitology 117, 311319.CrossRefGoogle ScholarPubMed
Cebria, F. and Newmark, P. A. (2005). Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture. Development 132, 36913703.CrossRefGoogle ScholarPubMed
Chai, M., McManus, D. P., McInnes, R., Moertel, L. P., Tran, M., Loukas, M., Jones, M. K. and Gobert, G. N. (2006). Transcriptome profiling of lung schistosomula, in vitro cultured schistosomula, and the adult Schistosoma japonicum. Molecular and Cellular Life Sciences 63, 919929.CrossRefGoogle ScholarPubMed
Cheever, A. W. (1965). A comparative study of Schistosoma mansoni infections in mice, gerbils and multimammate rats: I. The relation of portal hypertension to size of hepatic granulomas. American Journal of Tropical Medicine and Hygiene 14, 211226.CrossRefGoogle Scholar
Cheever, A. W., Hoffmann, K. F. and Wynn, T. A. (2000). Immunopathology of schistosomiasis mansoni in mice and men. Immunology Today 21, 465466.CrossRefGoogle ScholarPubMed
Cheever, A. W., Lewis, F. A. and Wynn, T. A. (1997). Schistosoma mansoni: unisexual infections sensitize mice for granuloma formation around intravenously injected eggs. Parasitology Research 83, 5759.CrossRefGoogle ScholarPubMed
Cheever, A. W., Poindexter, R. W. and Wynn, T. A. (1999). Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment. Infection and Immunity 67, 22012208.CrossRefGoogle ScholarPubMed
Chen, L., Rao, K. V. N., He, Y. X. and Ramaswamy, K. (2002). Skin stage schistosomula of Schistosoma mansoni produce an apoptosis-inducing factor that can cause apoptosis of T cells. Journal of Biological Chemistry 277, 3432934335.CrossRefGoogle ScholarPubMed
Chen, Q., Rehman, S., Smant, G. and Jones, J. T. (2005). Functional analysis of pathogenicity proteins of the potato cyst nematode Globodera rostochiensis using RNAi. Molecular Plant Microbe Interactions 18, 621625.CrossRefGoogle ScholarPubMed
Chlichlia, K., Schauwienold, B., Kirsten, C., Doenhoff, M. J., Fishelson, Z. and Ruppel, A. (2005). Schistosoma japonicum reveals distinct reactivity with antisera directed to proteases mediating host infection and invasion by cercariae of S. mansoni or S. haematobium. Parasite Immunology 27, 97102.CrossRefGoogle ScholarPubMed
Chmiela, M., Wadstrom, T., Folkesson, H., Planeta, M. I., Czkwianianc, E., Rechcinski, T. and Rudnicka, W. (1998). Anti-Lewis X antibody and Lewis X-anti-Lewis X immune complexes in Helicobacter pylori infection. Immunology Letters 61, 119125.CrossRefGoogle ScholarPubMed
Chun, J., Kwon, T., Lee, E. J., Kim, C. H., Han, Y. S., Hong, S. K., Hyun, S. and Kang, S. S. (2004). 14-3-3 Protein mediates phosphorylation of microtubule-associated protein tau by serum- and glucocorticoid-induced protein kinase 1. Molecules and Cells 18, 360368.CrossRefGoogle ScholarPubMed
Cioffi, D. L., Wu, S., Alexeyev, M., Goodman, S. R., Zhu, M. X. and Stevens, T. (2005). Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. Circulation Research 25, 11641172.CrossRefGoogle Scholar
Cioli, D., Botros, S. S., Wheatcroft-Francklow, K., Mbaye, A., Southgate, V., Tchuente, L. A., Troini, A. R., El-Din, S. H., Sabra, A. N., Alton, J., Engels, D. and Doenhoff, M. (2004). Determination of ED50 values for praziquantel in praziquantel resistant and praziquantel susceptible Schistosoma mansoni. International Journal for Parasitology 34, 979987.CrossRefGoogle ScholarPubMed
Cioli, D. and Pica-Mattoccia, L. (2003). Praziquantel. Parasitology Research 90 (Suppl.1), S3S9.CrossRefGoogle ScholarPubMed
Clegg, J. A. (1965). In vitro cultivation of Schistosoma mansoni. Experimental Parasitology 16, 133147.CrossRefGoogle ScholarPubMed
Clegg, J. A. (1974). Host antigens and the immune response in schistosomiasis. In Parasites in the Immunised Host: Mechanisms of Survival (ed. Porter, R. and Knight, J.), pp. 161176. Elsevier, North Holland, The Netherlands.Google Scholar
Clegg, J. A. and Smithers, S. R. (1972). The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro. International Journal for Parasitology 2, 7998.CrossRefGoogle ScholarPubMed
Colley, D. and Wikel, S. K. (1974). Schistosoma mansoni: Simplified method for the production of schistosomules. Experimental Parasitology 35, 4451.CrossRefGoogle ScholarPubMed
Cooke, A., Tonks, P., Jones, F. M., O'Shea, H., Hutchings, P., Fulford, A. J. C. and Dunne, D. W. (1999). Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice. Parasite Immunology 21, 169176.CrossRefGoogle ScholarPubMed
Cooke, A., Zaccone, P., Raine, T., Phillips, J. M. and Dunne, D. W. (2004). Infection and autoimmunity: are we winning the war, only to lose the peace? Trends in Parasitology 20, 316321.CrossRefGoogle ScholarPubMed
Cooper, P. J. (2004). The potential impact of early exposures to geohelminth infections on the development of atopy. Clinical Reviews in Allergy and Immunology 26, 514.CrossRefGoogle ScholarPubMed
Cornford, E. G. (1985). Schistosoma mansoni, S. japonicum, and S. haematobium: permeability to acidic amino acids and effect of separated and unseparated adults. Experimental Parasitology 59, 355363.CrossRefGoogle ScholarPubMed
Cornford, E. M. and Oldendorf, W. H. (1979). Transintegumental uptake of metabolic substrates in male and female Schistosoma mansoni. Journal of Parasitology 65, 357363.CrossRefGoogle ScholarPubMed
Coulson, P. S. and Wilson, R. A. (1989). Portal shunting and resistance to Schistosoma mansoni in 129 strain mice. Parasitology 99, 383389.CrossRefGoogle ScholarPubMed
Crabtree, J. E. and Wilson, R. A. (1986). Schistosoma mansoni: an ultrastructural examination of pulmonary migration. Parasitology 92, 343354.CrossRefGoogle ScholarPubMed
Crabtree, J. E. and Wilson, R. A. (1987). Pulmonary cellular reactions to Schistosoma mansoni schistosomula in normal and vaccinated mice. Advances in Experimental Medical Biology 216A, 701707.CrossRefGoogle ScholarPubMed
Crispe, I. N. (2003). Hepatic T cells and liver tolerance. Nature Reviews Immunology 3, 5162.CrossRefGoogle ScholarPubMed
Crompton, M. (1999). The mitochondrial permeability transition pore and its role in cell death. The Biochemical Journal 341, 233249.CrossRefGoogle ScholarPubMed
Cunha, V. M. N., Meyer-Fernandes, J. R. and Noel, F. (1992). A (Ca++-Mg++)ATPase from Schistosoma mansoni is coupled to an active transport of calcium. Molecular and Biochemical Parasitology 52, 167174.CrossRefGoogle Scholar
Curwen, R. S., Ashton, P. D., Sundaralingam, S. and Wilson, R. A. (2006). Identification of novel protease and immunomodulators in the secretions of schistosome cercariae that facilitate host entry. Molecular and Cellular Proteonomics 5, 835844.CrossRefGoogle ScholarPubMed
Curwen, R. S. and Wilson, R. A. (2003). Invasion of skin by schistosome cercariae: some neglected facts. Trends in Parasitology 19, 6366.CrossRefGoogle ScholarPubMed
Cushley, W. and Kusel, J. R. (1987). Interaction of the plant toxin, ricin, with different life-cycle stages of Schistosoma mansoni. Molecular and Biochemical Parasitology 24, 6771.CrossRefGoogle ScholarPubMed
Cutts, L. and Wilson, R. A. (1997). The protein antigens secreted in vivo by adult male Schistosoma mansoni. Parasitology 114, 245255.CrossRefGoogle ScholarPubMed
Dahl, S. G., Sylte, I. and Ravna, A. W. (2004). Structures and models of transporter proteins. Journal of Pharmacology and Experimental Therapeutics 309, 853860.CrossRefGoogle ScholarPubMed
Damian, R. T. (1987). The exploitation of immune responses by parasites: presidential address. Journal of Parasitology 73, 313.CrossRefGoogle Scholar
Damian, R. T., Greene, N. D. and Hubbard, W. J. (1973). Occurrence of mouse 2-macroglobulin antigenic determinants on Schistosoma mansoni adults, with evidence on their nature. Journal of Parasitology 59, 6473.CrossRefGoogle ScholarPubMed
Darani, H. Y., Curtis, R. H., McNeice, C., Price, H. P., Sayers, H. R. and Doenhoff, M. J. (1997). Schistosoma mansoni: anomalous immunogenic properties of a 27kDa larval serine protease associated with protective immunity. Parasitology 115, 237247.CrossRefGoogle Scholar
Davies, A., Douglas, L., Hendrich, J., Wratten, J., Tran, V. M., Foucault, I., Koch, D., Pratt, W. S., Saibil, H. R. and Dolphin, A. C. (2006). The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. Journal of Neuroscience 26, 87488757.CrossRefGoogle ScholarPubMed
Davies, A. J., Hall, J. G., Targett, G. A. and Murray, M. (1980). The biological significance of the immune response with special reference to parasites and cancer. Journal of Parasitology 66, 705721.CrossRefGoogle ScholarPubMed
Davies, S. J., Grogan, J. L., Blank, R. B., Lim, K. C., Locksley, R. M. and McKerrow, J. H. (2001). Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science 294, 13581361.CrossRefGoogle ScholarPubMed
Davies, S. J. and Pearce, E. (1995). Surface-associated serine-threonine kinase in adult Schistosoma mansoni. Molecular and Biochemical Parasitology 70, 3144.CrossRefGoogle Scholar
Davies, S. J., Shoemaker, C. B. and Pearce, E. J. (1998). A divergent member of the transforming growth factor beta receptor family from Schistosoma mansoni is expressed on the parasite surface membrane. Journal of Biological Chemistry 273, 1123411240.CrossRefGoogle ScholarPubMed
Day, T. A., Bennett, J. L. and Pax, R. A. (1992). Schistosoma mansoni: patch clamp study of a non-selective cation channel in the outer tegumental membrane of the adult female worm. Experimental Parasitology 74, 348356.CrossRefGoogle Scholar
Dean, D. A. (1977). Decreased binding of cytotoxic antibody by developing Schistosoma mansoni. Evidence for surface change independent of host antigen adsorption and membrane turnover. Journal of Parasitology 63, 418426.CrossRefGoogle ScholarPubMed
Debry, P., Nash, E. A., Neklason, D. W. and Metherall, J. E. (1997). Role of multidrug resistance P-glycoproteins in cholesterol esterification. Journal of Biological Chemistry 272, 10261031.CrossRefGoogle ScholarPubMed
de la Fuente, J. M., Eaton, P., Barrientos, A. G., Menendez, M. and Penades, S. (2005). Thermodynamic evidence for Ca2+-mediated self-aggregation of Lewis X gold glyconanoparticles. A model for cell adhesion via carbohydrate-carbohydrate interaction. Journal of the American Chemical Society 127, 61926197.CrossRefGoogle Scholar
Deng, J., Gold, D., LoVerde, P. T. and Fishelson, Z. (2003). Inhibition of membrane attack complex of complent by Schistosoma mansoni paramyosin. Infection and Immunity 71, 64026410.CrossRefGoogle Scholar
De Riso, L., Ristoratore, F., Sebastiano, M. and Bazzicalupo, P. (1994). Amphid defective mutant of Caenorhabditis elegans. Genetica 94, 195202.CrossRefGoogle ScholarPubMed
de Vijver, K. K. V., Hokke, C. H., van Remoortere, A., Jacobs, W., Deelder, A. M. and van Marck, E. A. (2004). Glycans of Schistosoma mansoni and keyhole limpet haemocyanin induce hepatic granulomas in vivo. International Journal for Parasitology 34, 951961.CrossRefGoogle Scholar
Dillon, G. P., Feltwell, T., Skelton, J. P., Ashton, P. D., Coulson, P. S., Quail, M. A., Nikolaidou-Katsaridou, N., Wilson, R. A. and Ivens, A. C. (2006). Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni. International Journal for Parasitology 36, 18.CrossRefGoogle ScholarPubMed
Dingle, J. T. and Lucy, J. A. (1965). Membrane phenomena in relation to vitamin A. Proceedings of the Nutrition Society 24, 170172.CrossRefGoogle Scholar
Doctor, R., Dahl, R., Fouassier, L., Kilic, G. and Fitz, J. G. (2002). Cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover. American Journal of Physiological Cell Physiology 282, C1042C1052.CrossRefGoogle ScholarPubMed
Doenhoff, M. J. (1997). A role for granulomatous inflammation in the transmission of infectious disease: schistosomiasis and tuberculosis. Parasitology 115, S113S125.CrossRefGoogle ScholarPubMed
Doenhoff, M. J. (1998). Granulomatous inflammation and the transmission of infection: schistosomiasis – and TB too? Immunology Today 19, 462467.CrossRefGoogle ScholarPubMed
Doenhoff, M. J. (2003). Granulomas are not just gizmos for immunologists. Trends in Immunology 24, 168169; author reply 169170.CrossRefGoogle Scholar
Doenhoff, M. J. (2006). Subversion of the immune response by helminths. In Microbial Subversion of Immunity: Current Topics (ed. Lachmann, P. J. and Oldstone, M. B. A.), pp. 107176. Caister Academic Press, Norfolk, England.Google Scholar
Doenhoff, M. J., Chiodini, P. L. and Hamilton, J. V. (2004). Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies? Trends in Parasitology 20, 3539.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Hassounah, O. A. and Lucas, S. B. (1985). Does the immunopathology induced by schistosome eggs potentiate parasite survival. Immunology Today 6, 203206.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Hassounah, O., Murare, H., Bain, J. and Lucas, S. (1986). The schistosome egg granuloma: immunopathology in the cause of host protection or parasite survival. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 503514.CrossRefGoogle ScholarPubMed
Doenhoff, M., Musallam, R., Bain, J. and McGregor, A. (1978). Studies on the host-parasite relationship in Schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion. Immunology 35, 771778.Google ScholarPubMed
Doenhoff, M., Musallam, R., Bain, J. and McGregor, A. (1979). Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. I. Pathogenesis. American Journal of Tropical Medicine and Hygiene 28, 260263.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Pearson, S., Dunne, D. W., Bickle, Q., Lucas, S., Bain, J., Musallam, R. and Hassounah, O. (1981). Immunological control of hepatotoxicity and parasite egg excretion in Schistosoma mansoni infections – stage specificity of the reactivity of immune serum in T-cell deprived mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 4153.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Sabah, A. A., Fletcher, C., Webbe, G. and Bain, J. (1987). Evidence for an immune-dependent action of praziquantel on Schistosoma mansoni in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 947951.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Stanley, R. G., Griffiths, K. and Jackson, C. L. (2002). An anti-atherogenic effect of Schistosoma mansoni infections in mice associated with a parasite-induced lowering of blood total cholesterol. Parasitology 125, 415421.CrossRefGoogle ScholarPubMed
Doenhoff, M. J., Stanley, R. G., Pryce, D., Curtis, R. C., Parry, H., Griffiths, K. and Jackson, C. L. (2003). Identification of a fibrinolytic enzyme in Schistosoma mansoni eggs and modulated blood fibrinogen metabolism in S. mansoni-infected mice. Parasitology 126, 231234.CrossRefGoogle ScholarPubMed
Domingo, E. O. and Warren, K. S. (1968). Endogenous desensitization: changing host granulomatous response to schistosome eggs at different stages of infection with Schistosoma mansoni. American Journal of Pathology 52, 369379.Google Scholar
Doolley, J. S. and Trust, T. J. (1988). Surface protein composition of Aeromonas hydrophila strains virulent for fish: identification of a surface array protein. Journal of Bacteriology 170, 499506.CrossRefGoogle Scholar
Dorsey, C. H. and Cousin, C. E. (1986). Schistosoma mansoni: a new parenchymal cell in cercariae. Experimental Parasitology 61, 3341.CrossRefGoogle ScholarPubMed
Dourmashkin, R. R., Deteix, P., Simone, C. B. and Henkart, P. A. (1980). Electron microscopic demonstration of lesions in target cell membranes associated with antibody dependent cellular cytotoxicity. Clinical and Experimental Immunology 42, 554563.Google ScholarPubMed
Dunne, D. W., Hassounah, O., Musallam, R., Lucas, S., Pepys, M. B., Baltz, M. and Doenhoff, M. (1983). Mechanisms of Schistosoma mansoni egg excretion: parasitological observations in immunosuppressed mice reconstituted with immune serum. Parasite Immunology 5, 4760.CrossRefGoogle ScholarPubMed
Dunne, D. W., Jones, F. M. and Doenhoff, M. J. (1991). The purification, characterization, serological activity and hepatotoxic properties of two cationic glycoproteins (alpha-1 and omega-1) from Schistosoma mansoni eggs. Parasitology 103, 225236.CrossRefGoogle ScholarPubMed
Dunne, D. W., Lucas, S., Bickle, Q., Pearson, S., Madgwick, L., Bain, J. and Doenhoff, M. J. (1981). Identification and partial purification of an antigen (omega-1) from Schistosoma mansoni eggs which is putatively hepatotoxic in T-cell deprived mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 5471.CrossRefGoogle ScholarPubMed
Duvaux-Miret, D., Stefano, G. B., Smith, E. M., Mallozzi, L. A. and Capron, A. (1992). Proopiomelanocortin-derived peptides as tools of immune evasion for the human trematode Schistosoma mansoni. Acta Biologia Hungarica 43, 281286.Google ScholarPubMed
Dyer, M. and Day, K. P. (2003). Regulation of the rate of asexual growth and commitment to sexual development by diffusible factors from in vitro cultures of Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene 68, 403409.CrossRefGoogle ScholarPubMed
Eggens, I., Fenderson, B., Toyokuni, T., Dean, B., Stroud, M. and Hakomori, S. (1989). Specific interaction between Lex and Lex determinants. A possible basis for cell recognition in preimplantation embryos and in embryonal carcinoma cells. Journal of Biological Chemistry 264, 94769484.CrossRefGoogle ScholarPubMed
Egner, R., Mahe, Y., Pandjaitan, R. and Kuchler, K. (1995). Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Molecular and Cellular Biology 15, 58795887.CrossRefGoogle ScholarPubMed
Eliseenkova, A. V., Ktitorova, O. V., Kakpakova, E. S., Sidorova, T. A. and Stavrovskaya, A. A. (1998). Induction of P-glycoprotein functional activity and multidrug resistance by a soluble factor(s) produced by some mammalian cells. Membrane and Cellular Biology 12, 469479.Google ScholarPubMed
El Awady, M. K., Gad, Y. Z., Wen, Y., Eassawi, M., Effat, L., Amr, K. S., Ismail, S. and Christ, G. J. (2001). Schistosoma hematobium soluble egg antigens induce proliferation of urothelial and endothelial cells. World Journal of Urology 19, 263266.CrossRefGoogle ScholarPubMed
El Ridi, R. and Tallima, H. (2006). Equilibrium in lung schistosomula sphingomyelin breakdown and biosynthesis allows very small molecules, but not antibody, to access proteins at the host-parasite interface. Journal of Parasitology 92, 730737.CrossRefGoogle Scholar
El Ridi, R., Tallima, H., Mohamed, S. H. and Montash, M. (2004). Depletion of Schistosoma mansoni lung stage schistosomula cholesterol by methyl-beta cyclodextrin dramatically increases specific antibody binding to surface membrane antigens. Journal of Parasitology 90, 727732.CrossRefGoogle ScholarPubMed
Emerson, S. G. and Cone, R. E. (1981). Regulation of murine B lymphocyte plasma membrane protein turnover and shedding. Journal of Cellular Physiology 109, 2535.CrossRefGoogle ScholarPubMed
Endicott, J. A. and Ling, V. (1989). The biochemistry of P glycoprotein mediated drug resistance. Annual Review of Biochemistry 58, 137171.CrossRefGoogle Scholar
Erasmus, D. A. (1987). The adult schistosome: structure and reproductive biology. In Biology of Schistosomes, from Genes to Latrines (ed. Rollinson, D. and Simpson, A. J. G.), pp. 5176. Academic Press, London.Google Scholar
Falcone, F. H. and Pritchard, D. I. (2005). Parasite role reversal: worms on trial. Trends in Parasitology 21, 157160.CrossRefGoogle ScholarPubMed
Fallon, P. G. and Dunne, D. W. (1999). Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection. Journal of Immunology 162, 41224132.CrossRefGoogle ScholarPubMed
Fallon, P., Teixeira, M. M., Neice, C. M., Williams, P. J., Hellewell, T. J. and Doenhoff, M. J. (1996). Enhancement of Schistosoma mansoni infectivity by intradermal injections of larval extracts: a putative role for larval proteases. Journal of Infectious Diseases 173, 14601466.CrossRefGoogle ScholarPubMed
Fetterer, R. H., Pax, R. A., Bennet, J. L. and Bennett, J. L. (1981). Na+/K+ transport and tegumental membrane potential in adult male Schistosoma mansoni. Parasitology 82, 97109.CrossRefGoogle ScholarPubMed
File, S. (1995). Interaction of schistosome eggs with vascular endothelium. Journal of Parasitology 81, 234238.CrossRefGoogle ScholarPubMed
Finken, M., Sobek, A., Symmons, P. and Kunz, W. (1994). Characterisation of the complete protein disulfide isomerase gene of Schistosoma mansoni and identification of the tissues of its expression. Molecular and Biochemical Parasitology 64, 135144.CrossRefGoogle ScholarPubMed
Fitzpatrick, J. M. and Hoffmann, K. F. (2006). Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing. International Journal for Parasitology 36, 10811089.CrossRefGoogle ScholarPubMed
Fitzsimmons, C. M., Schramm, G., Jones, F. M., Chalmers, I. W., Hoffmann, K. F., Grevelding, C. G., Wuhrer, M., Hokke, C. H., Haas, H., Doenhoff, M. J. and Dunne, D. W. (2005). Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 144, 123127.CrossRefGoogle ScholarPubMed
Foley, M., MacGregor, A. N., Kusel, J. R., Garland, P. B., Downie, T. and Moore, I. (1986). The lateral diffusion of lipid probes in the surface membrane of Schistosoma mansoni. Journal of Cell Biology 103, 807818.CrossRefGoogle ScholarPubMed
Forsyth, K. D., Simpson, A. C. and Levinsky, R. J. (1989). CD15 antibodies increase neutrophil adhesion to endothelium by an LFA-1-dependent mechanism. European Journal of Immunology 19, 13311334.CrossRefGoogle ScholarPubMed
Foster, C. B., Flanigan, T. P., DeStigter, K. K., Blanton, R., Dumenco, L. L., Gallagher, C. and Ratnoff, O. D. (1992). Inhibition of the activation of Hageman factor (factor XII) by extracts of Schistosoma mansoni. Journal of Laboratory and Clinical Medicine 120, 735739.Google ScholarPubMed
Freedman, D. O. and Ottesen, E. A. (1988). Eggs of Schistosoma mansoni stimulate endothelial cell proliferation in vitro. Journal of Infectious Diseases 158, 556562.CrossRefGoogle ScholarPubMed
Freitag, H., Neupert, W. and Benz, R. (1982). Purification and characterisation of a pore protein of the outer mitochondrial membrane from Neurospora crassa. European Journal of Biochemistry 123, 629636.CrossRefGoogle ScholarPubMed
Funatsu, N., Kumanogoh, H., Sokawa, Y. and Maekawa, S. (2000). Identification of gelsolin as an actin regulatory component in a Triton insoluble low density fraction (raft) of newborn bovine brain. Neuroscience Research 36, 311317.CrossRefGoogle Scholar
Fusco, A. C., Salafsky, B. and Delbrook, K. (1986). Schistosoma mansoni: production of cercarial eicosanoids as correlates of penetration and transformation. Journal of Parasitology 72, 397404.CrossRefGoogle ScholarPubMed
Gadsby, D. and Nairn, A. C. (1999). Control of CTFR channel gating by phosphorylation and nucleotide hydrolysis. Physiological Reviews 79 (Suppl.), S77S107.CrossRefGoogle ScholarPubMed
Garrett, J. E., Capuano, I. V., Hammerland, L. G., Hung, B. C. P., Bron, E. M., Herbert, S. C., Nemeth, E. F. and Fuller, F. (1995). Molecular cloning and functional expression of human parathyroid hormone calcium sensing receptor cDNA's. Journal of Biological Chemistry 270, 1291912925.CrossRefGoogle Scholar
Gaus, K., Gratton, E., Kable, E. P., Jones, A. S., Gelissen, I., Kritharides, L. and Jessup, W. (2003). Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proceedings of the National Academy of Sciences USA 100, 1555415559.CrossRefGoogle ScholarPubMed
Ghendler, Y., Parizade, M., Arnon, R., McKerrow, J. H. and Fishelson, Z. (1996). Schistosoma mansoni: evidence for a 28 kDa membrane–bound protease on schistosomula. Experimental Parasitology 83, 7382.CrossRefGoogle Scholar
Gohla, A. and Bokoch, G. M. (2002). 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Current Biology 12, 17041710.CrossRefGoogle ScholarPubMed
Golan, D. E., Brown, C. S., Cianci, C. M., Furlong, S. T. and Caulfield, J. P. (1986). Schistosomula of Schistosoma mansoni use lysophosphatgidylcholine to lyse human red cells and immobilize cell membrane components. Journal of Cell Biology 103, 819828.CrossRefGoogle ScholarPubMed
Goldring, O. L., Kusel, J. R. and Smithers, S. R. (1977 a). Schistosoma mansoni: origin in vitro of host-like surface antigens. Experimental Parasitology 43, 8293.CrossRefGoogle ScholarPubMed
Goldring, O. L., Sher, A., Smithers, S. R. and McLaren, D. J. (1977 b). Host antigens and parasite antigens of murine Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 71, 144148.CrossRefGoogle ScholarPubMed
Gonnert, R. and Andrews, P. (1977). Praziquantel, a new board-spectrum antischistosomal agent. Zeitschrift für Parasitenkunde 52, 129150.CrossRefGoogle ScholarPubMed
Goodman, M. B., Ernstrom, G. G., Chelur, D. S., O'Hagan, R., Yao, C. A. and Chalfie, M. (2002). MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature, London 415, 10391042.CrossRefGoogle ScholarPubMed
Gradilone, S. A., Garcia, F., Huebert, R. C., Tietz, P. S., Larocca, M. C., Kierbel, A., Carreras, F. L., Larusso, N. F. and Marinelli, R. A. (2003). Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes. Hepatology 37, 14351441.CrossRefGoogle ScholarPubMed
Greenberg, R. M. (2005). Are Ca2+ channels targets of praziquantel action? International Journal for Parasitology 35, 19.CrossRefGoogle ScholarPubMed
Grevelding, C. (2006). Transgenic flatworms. In Parasitic Flatworms – Molecular Biology, Biochemistry, Immunology and Physiology (ed. Maule, A. G. and Marks, N. J.). CAB International. Wallingford, UK.Google Scholar
Grevelding, C. G. (1995). The female-specific W1 sequence of the Puerto Rican strain of Schistosoma mansoni occurs in both genders of a Liberian strain. Molecular and Biochemical Parasitology 71, 269272.CrossRefGoogle ScholarPubMed
Grevelding, C. G., Sommer, G. and Kunz, W. (1997). Female-specific gene expression in Schistosoma mansoni is regulated by pairing. Parasitology 115, 635640.CrossRefGoogle ScholarPubMed
Grimaud, J. A., Borojevic, R. and Araujo Dos, Santos H. (1976). Schistosomal pigment in human and murine infections with Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 70, 7377.CrossRefGoogle ScholarPubMed
Gryseels, B., Polman, K., Clerinx, J. and Kestens, L. (2006). Human schistosomiasis. Lancet 368, 11061118.CrossRefGoogle ScholarPubMed
Gui, M., Kusel, J. R., Shi, Y. E. and Ruppel, A. (1995). Schistosoma japonicum and S. mansoni: comparison of larval migration patterns in mice. Journal of Helminthology 69, 1925.CrossRefGoogle ScholarPubMed
Gupta, B. C. and Basch, P. F. (1987). The role of Schistosoma mansoni males in feeding and development of female worms. Journal of Parasitology 73, 481486.CrossRefGoogle ScholarPubMed
Haisch, K., Schramm, G., Falcone, F. H., Alexander, C., Schlaak, M. and Haas, H. (2001). A glycoprotein from Schistosoma mansoni eggs binds non-antigen-specific immunoglobulin E and releases interleukin-4 from human basophils. Parasite Immunology 23, 427434.CrossRefGoogle ScholarPubMed
Hamed, R. R., Maharem, T. M. and El Guindy, A. S. (1997). Proteoglycans from adult worms of Schistosoma haematobium. Journal of Helminthology 71, 151160.CrossRefGoogle ScholarPubMed
Hamilton, J. V., Chiodini, P. L., Fallon, P. G. and Doenhoff, M. J. (1999). Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens. Parasitology 118, 8389.CrossRefGoogle ScholarPubMed
Hanna, W. F., Kerr, C. L., Shaper, J. H. and Wright, W. W. (2004). Lewis X-containing reaction in capacitated mouse sperm. Biology of Reproduction 71, 778789.CrossRefGoogle ScholarPubMed
Harn, D. A., Cianci, C. M. and Caulfield, J. P. (1989). Schistosoma mansoni: immunization with cercarial glycocalyx preparation increases the adult worm burden. Experimental Parasitolology 68, 108110.CrossRefGoogle ScholarPubMed
Harnett, W. and Kusel, J. R. (1986). Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology 93, 401405.CrossRefGoogle ScholarPubMed
Harnett, W., Kusel, J. R. and Barrowman, M. M. (1985). The use of aldehydes to show the relationship between host and parasite antigens at the surface of adult male Schistosoma mansoni. Parasite Immunology 7, 415428.CrossRefGoogle ScholarPubMed
Harrison, R. A. and Doenhoff, M. J. (1983). Retarded development of Schistosoma mansoni in immunosuppressed mice. Parasitology 86, 429438.CrossRefGoogle ScholarPubMed
Harrop, R., Coulson, P. S. and Wilson, R. A. (1999). Characterization, cloning and immunogenicity of antigens released by lung-stage larvae of Schistosoma mansoni. Parasitology 118, 583594.CrossRefGoogle ScholarPubMed
Harrop, R. and Wilson, R. A. (1993). Protein synthesis and release by cultured schistosomula of Schistosoma mansoni. Parasitology 107, 265274.CrossRefGoogle ScholarPubMed
Haseeb, M., Eveland, L. K. and Fried, B. (1985). The uptake, localisation and transfer of C14 cholesterol in Schistosoma mansoni males and females maintained in vitro. Comparative Biochemistry and Physiology 82A, 421423.CrossRefGoogle Scholar
Hassounah, O. A. and Doenhoff, M. J. (1993). Comparison of the hepatoprotective effects of immune cells and serum in Schistosoma mansoni-infected immunosuppressed mice. Parasite Immunology 15, 657661.CrossRefGoogle ScholarPubMed
Hayashi, N., Matsui, K., Tsutsui, H., Osada, Y., Mohamed, R. T., Nakano, H., Kashiwamura, S., Hyodo, Y., Takeda, K., Akira, S., Hada, T., Higashino, K., Kojima, S. and Nakanishi, K. (1999). Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens. Journal of Immunology 163, 67026711.CrossRefGoogle ScholarPubMed
Hayashi, Y., Hironaka, K., Shikata, K., Ogawa, S., Ota, K., Wada, J., Kamata, K., Ota, Z. and Makino, H. (2001). Ultrastructure of glomerular basement membrane in active heymann nephritis rats revealed by tissue-negative staining method. American Journal of Nephrology 21, 249255.CrossRefGoogle ScholarPubMed
Head, B. P., Patel, H. H., Roth, D. M., Murray, F., Swaney, J. S., Niesman, I. R., Farquhar, M. G. and Insel, P. A. (2006). Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. Journal of Biological Chemistry 281, 2639126399.CrossRefGoogle ScholarPubMed
Herbert, D. R., Holscher, C., Mohrs, M., Arendse, B., Schwegmann, A., Radwanska, M., Leeto, M., Kirsch, R., Hall, P., Mossmann, H., Claussen, B., Forster, I. and Brombacher, F. (2004). Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20, 623635.CrossRefGoogle ScholarPubMed
Hernandez, D. C., Kim, K. C., McKerrow, J. H. and Davies, S. J. (2004). Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Experimental Parasitology 106, 5961.CrossRefGoogle ScholarPubMed
Herve, M., Angeli, V., Pinzar, E., Wintjens, R., Faveeuw, C., Narumiya, S., Capron, A., Urade, Y., Capron, M., Riveau, G. and Trottein, F. (2003). Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion. European Journal of Immunology 33, 27642772.CrossRefGoogle Scholar
Hirano, K., Iiizumi, Y., Mori, Y., Toyoshi, K., Sugiura, M. and Iino, S. (1985). Role of alkaline phosphatase in phosphate uptake into brush border membrane vesicles from human intestinal mucosa. Journal of Biochemistry 97, 14611466.CrossRefGoogle ScholarPubMed
Hockley, D. J. (1973). Ultrastructure of the tegument of Schistosoma. Advances in Parasitology 11, 233305.CrossRefGoogle ScholarPubMed
Hockley, D. J. and McLaren, D. J. (1973). Schistosoma mansoni: changes in the outer membrane of the tegument during development from cercaria to adult worm. International Journal for Parasitology 3, 1325.CrossRefGoogle ScholarPubMed
Hockley, D. J., McLaren, D. J., Ward, B. J. and Nermut, M. V. (1975). A freeze–fracture study of the tegumental membrane of Schistosoma mansoni (Platyhelminthes:) Tissue and Cell 7, 485496.CrossRefGoogle ScholarPubMed
Holowka, D., Gosse, J. A., Hammond, A. T., Han, X., Sengupta, P., Smith, N. L., Wagenknecht-Wiesner, A., Wu, M., Young, R. M. and Baird, B. (2005). Lipid segregation and IgE receptor signaling: a decade of progress. Biochimica et Biophysica Acta 1746, 252259.CrossRefGoogle ScholarPubMed
Holowka, D., Sheets, E. D. and Baird, B. (2000). Interactions between Fc(epsilon)RI and lipid raft components are regulated by the actin cytoskeleton. Journal of Cell Science 113, 10091019.CrossRefGoogle ScholarPubMed
Hu, W., Brindley, P. J., McManus, D. P., Feng, Z. and Han, Z. G. (2004). Schistosome transcriptomes: new insights into the parasite and schistosomiasis. Trends in Molecular Medicine 10, 217225.CrossRefGoogle ScholarPubMed
Imai, S. and Fujita, K. (2004). Molecules of parasites as immunomodulatory drugs. Current Topics in Medicinal Chemistry 4, 539552.CrossRefGoogle ScholarPubMed
Jacobs, W., Deelder, A., Bogers, J., van de Vijver, K. and van Marck, E. (1999 a). Schistosomal granuloma modulation III. Schistosoma haematobium worms accelerate S. mansoni soluble egg antigen-induced hepatic granuloma formation in vivo. Parasitology Research 85, 905909.CrossRefGoogle ScholarPubMed
Jacobs, W., van Dam, G., Bogers, J., Deelder, A. and van Marck, E. (1999 b). Schistosomal granuloma modulation. I. Schistosoma mansoni worm antigens CAA and CCA prime egg-antigen-induced hepatic granuloma formation. Parasitology Research 85, 713.CrossRefGoogle ScholarPubMed
Janas, E., Priest, R. and Malhotra, R. (2005). Functional role of lipid rafts in CD20 activity? Biochemical Society Symposia 72, 165175.Google Scholar
Jones, J. T., Helm, C. N. and Kusel, J. R. (1988). Variation of susceptibility to Schistosoma mansoni to damage by polycations. Molecular and Biochemical Parasitology 30, 3544.CrossRefGoogle ScholarPubMed
Jones, J. T. and Kusel, J. R. (1989). Intra-specific variation in Schistosoma mansoni. Parasitology Today 5, 3739.CrossRefGoogle ScholarPubMed
Jones, M. K., Gobert, G. N., Zhang, L., Sunderland, P. and McManus, D. P. (2004). Cytoskeletal and motor proteins in human schistosomes and their roles in surface maintenance and host-parasite interactions. BioEssays 26, 752765.CrossRefGoogle ScholarPubMed
Kalkum, M., Lyon, G. J. and Chait, B. T. (2003). Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry. Proceedings of the National Academy of Sciences, USA 100, 27952800.CrossRefGoogle ScholarPubMed
Kannagi, R., Nudelman, E., Levery, S. B. and Hakamori, S.-I. (1982). A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1. Journal of Biological Chemistry 257, 1486514874.CrossRefGoogle Scholar
Kanse, S. M., Liang, O., Schubert, U., Haas, H., Preissner, K. T., Doenhoff, M. J. and Dennis, R. D. (2005). Characterisation and partial purification of Schistosoma mansoni egg-derived pro-angiogenic factor. Molecular and Biochemical Parasitology 144, 7685.CrossRefGoogle ScholarPubMed
Kaplan, G., Unkeless, J. C. and Cohn, Z. A. (1979). Insertion and turnover of macrophage plasma membrane proteins. Proceedings of the National Academy of Sciences, USA 76, 38243828.CrossRefGoogle ScholarPubMed
Kapp, K., Knobloch, J., Schussler, P., Sroka, S., Lammers, R., Kunz, W. and Grevelding, C. G. (2004). The Schistosoma mansoni Src kinase TK3 is expressed in the gonads and likely involved in cytoskeletal organization. Molecular and Biochemical Parasitology 138, 171182.CrossRefGoogle ScholarPubMed
Kapp, K., Schussler, P., Kunz, W. and Grevelding, C. G. (2001). Identification, isolation and characterization of a Fyn-like tyrosine kinase from Schistosoma mansoni. Parasitology 122, 317327.CrossRefGoogle ScholarPubMed
Karanja, D. M. S., Colley, D. G., Nahlen, B. L., Ouma, J. H. and Secor, W. E. (1997). Studies on schistosomiasis in western Kenya. 1. Evidence for immune-facilitated excretion of schistosome eggs from patients with Schistosoma mansoni and human immunodeficiency virus coinfections. American Journal of Tropical Medicine and Hygiene 56, 515521.CrossRefGoogle ScholarPubMed
Keefe, D., Shi, L., Feske, S., Massol, R., Navarro, F., Kirchhausen, T. and Lieberman, J. (2005). Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity 23, 249262.CrossRefGoogle ScholarPubMed
Kim, E., Day, T. A., Marks, N., Johnson, R. N., Halton, D., Shaw, C., Chen, G. Z., Bennett, J. L. and Pax, R. A. (1995 a). Immunohistochemical localization of a shaker-related voltage-gated potassium channel protein in Schistosoma mansoni (Trematoda: Digenea). Experimental Parasitology 81, 421429.CrossRefGoogle ScholarPubMed
Kim, J. S., Soucek, J., Matousek, J. and Raines, R. T. (1995 b). Mechanism of ribonuclease cytotoxicity. Journal of Biological Chemistry 270, 3109731102.CrossRefGoogle ScholarPubMed
Knobloch, J., Kunz, W. and Grevelding, C. G. (2006). Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni. International Journal forParasitology 36, 12611272.Google ScholarPubMed
Knolle, P. A. and Gerken, G. (2000). Local control of the immune response in the liver. Immunological Reviews 174, 2134.CrossRefGoogle ScholarPubMed
Knudsen, G. M., Medzihradszky, K. F., Lim, K. C., Hansell, E. and McKerrow, J. H. (2005). Proteomic analysis of Schistosoma mansoni cercarial secretions. Molecular and Cellular Proteomics 4, 18621875.CrossRefGoogle ScholarPubMed
Kovbasnjuk, O. N. and Spring, K. R. (2000). The apical membrane glycocalyx of MDCK cells. Journal of Membrane Biology 176, 1929.CrossRefGoogle ScholarPubMed
Kroemer, G., Zamzami, N. and Susin, S. A. (1997). Mitochondrial control of apoptosis. Immunology Today 18, 4451.CrossRefGoogle ScholarPubMed
Kusel, J. R. and Gordon, J. F. (1989). Biophysical studies on the schistosome surface and their relevance to its properties under immune and drug attack. Parasite Immunology 11, 431451.CrossRefGoogle ScholarPubMed
Kusel, J. R. and Mackenzie, P. E. (1975). The measurement of the relative turnover rates of proteins of the surface membrane of Schistosoma mansoni. Parasitology 71, 261273.CrossRefGoogle ScholarPubMed
Kusel, J. R., Mackenzie, P. E. and McLaren, D. J. (1975). The release of membrane antigens into culture by adult Schistosoma mansoni. Parasitology 71, 247259.CrossRefGoogle ScholarPubMed
Kusel, J. R., Oliviera, F. A., Coelho, P. M. Z., Mattos, A.-C., Reis, K., Lima, S. and Ribeiro, F. (2006). The effects of ions, poly-l-lysine and praziquantel on the excretory system of Schistosoma mansoni. Memorias do Oswaldo Cruz 101, 293298.CrossRefGoogle ScholarPubMed
Kusel, J. R., Stones, L. and Harnett, W. (1981). The use of membrane-active compounds to examine the structure of the surface membrane of Schistosoma mansoni. Bioscience Reports 1, 253261.CrossRefGoogle ScholarPubMed
Kusel, J. R., Stones, L. and Harnett, W. (1982). The effects of retinol (vitamin A alcohol) and various non-ionic detergents on the surfaces of schistosomula and adult Schistosoma mansoni. Molecular and Biochemical Parasitology 5, 147163.CrossRefGoogle ScholarPubMed
La Flamme, A. C., Ruddenklau, K. and Backstrom, B. T. (2003). Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infection and Immunity 71, 49965004.CrossRefGoogle ScholarPubMed
Lane, C. A., Pax, R. A. and Bennett, J. L. (1987). L-glutamine: an amino acid required for maintenance of the tegumental membrane potential of Schistosoma mansoni. Parasitology 94, 233242.CrossRefGoogle ScholarPubMed
Lejoly-Boisseau, H., Appriou, M., Seigneur, M., Pruvost, A., Tribouley-Duret, J. and Tribouley, J. (1999). Schistosoma mansoni: in vitro adhesion of parasite eggs to the vascular endothelium. Subsequent inhibition by a monoclonal antibody directed to a carbohydrate epitope. Experimental Parasitology 91, 2029.CrossRefGoogle Scholar
Lewis, F., Heiny, S. and Sher, F. A. (1985). Evidence against the existence of specific Schistosoma mansoni subpopulations which are resistant to irradiated vaccine-induced immunity. American Journal of Tropical Medicine and Hygiene 34, 8691.CrossRefGoogle ScholarPubMed
Lin, Y. L. and He, S. (2006). Sm22.6 antigen is an inhibitor to human thrombin. Molecular and Biochemical Parasitology 147, 95100.CrossRefGoogle ScholarPubMed
Lipton, J., Kleemann, G., Ghosh, R., Lints, R. and Emmons, S. W. (2004). Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate. Journal of Neuroscience 24, 74277434.CrossRefGoogle Scholar
Liu, F., Lu, J., Hu, W., Wang, S. Y., Cui, S. J., Chi, M., Yan, Q., Wang, X. R., Song, H. D., Xu, X. N., Wang, J. J., Zhang, X. L., Zhang, X., Wang, Z. Q., Xue, C. L., Brindley, P. J., McManus, D. P., Yang, P. Y., Feng, Z., Chen, Z. and Han, Z. G. (2006). New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. Public Library of Science, Pathogenesis 2, e29.Google ScholarPubMed
Livigni, A., Scorziello, A., Agnese, S., Adornetto, A., Carlucci, A., Garbi, C., Castaldi, I., Annuziato, L., Avvedimento, E. V. and Feliciello, A. (2006). Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism. Molecular and Cell Biology 17, 263271.CrossRefGoogle ScholarPubMed
Lo, S. K., Golenbock, D. T., Sass, P. M., Maskati, A., Xu, H. and Silverstein, R. L. (1997). Engagement of the Lewis X antigen (CD15) results in monocyte activation. Blood 89, 307314.CrossRefGoogle ScholarPubMed
Lockwich, T. P., Liu, X., Singh, B. B., Jadlowiec, J., Weiland, S. and Ambudkar, I. S. (2000). Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. Journal of Biological Chemistry 275, 1193411942.CrossRefGoogle Scholar
Loeffler, D. A., Lundy, S. K., Singh, K. P., Gerard, H. C., Hudson, A. P. and Boros, D. L. (2002). Soluble egg antigens from Schistosoma mansoni induce angiogenesis-related processes by up-regulating vascular endothelial growth factor in human endothelial cells. Journal of Infectious Diseases 185, 16501656.CrossRefGoogle ScholarPubMed
LoVerde, P. T., Niles, E. G., Osman, A. and Wu, W. (2005). Gender specific biology of Schistosoma mansoni: male/female interactions. In Schistosomiasis (ed. Secor, E. and Colley, D. G.), pp. 2745. Springer Verlag, Berlin.CrossRefGoogle Scholar
Lucas, S., Musallam, R., Bain, J., Hassounah, O., Bickle, Q. and Doenhoff, M. (1980). The pathological effects of immunosuppression of Schistosoma mansoni-infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with antithymocyte serum, and treatment with hydrocortisone acetate. Transactions of the Royal Society of Tropical Medicine and Hygiene 74, 633643.CrossRefGoogle ScholarPubMed
Lyons, K. M. (1973). The epidermis and sense organs of the monogenea and some related groups. Advances in Parasitology 11, 193232.CrossRefGoogle ScholarPubMed
MacGregor, A. N. and Kusel, J. R. (1989). Isolation and characterisation of a surface membrane glycoprotein from adult Schistosoma mansoni. Molecular and Biochemical Parasitology 34, 237244.CrossRefGoogle ScholarPubMed
MacGregor, A. N., Stott, D. I. and Kusel, J. R. (1985). Lectin binding in the surface membrane of Schistosoma mansoni. Molecular and Biochemical Parasitology 16, 163172.CrossRefGoogle ScholarPubMed
Magee, A. I. and Parmryd, I. (2003). Detergent-resistant membranes and the protein composition of lipid rafts. Genome Biology 4, 234237.CrossRefGoogle ScholarPubMed
Mair, G. R., Maule, A. G., Day, T. A. and Halton, D. W. (2000). A confocal microscopical study of the musculature of adult Schistosoma mansoni. Parasitology 121, 163170.CrossRefGoogle ScholarPubMed
Mair, G. R., Niciu, M. J., Stewart, M. T., Brennan, G., Omar, H., Halton, D. W., Mains, R., Eipper, B. A., Maule, A. G. and Day, T. A. (2004). A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni. FASEB Journal 18, 114121.CrossRefGoogle ScholarPubMed
Makarov, A. A. and Ilinskaya, O. N. (2003). Cytotoxic ribonucleases: molecular weapons and their targets. FEBS Letters 540, 1520.CrossRefGoogle ScholarPubMed
Margolis, S. S. and Kornbluth, S. (2004). When the checkpoints have gone: insights into Cdc25 functional activation. Cell Cycle 3, 425428.CrossRefGoogle ScholarPubMed
Maron, R., Palanivel, V., Weiner, H. L. and Harn, D. A. (1998). Oral administration of schistosome egg antigens and insulin B-chain generates and enhances Th2-type responses in NOD mice. Clinical Immunology and Immunopathology 87, 8592.CrossRefGoogle ScholarPubMed
Masyuk, A. I., Masyuk, T. V., Splinter, P. L., Huang, B. Q., Stroope, A. J. and LaRusso, N. F. (2006). Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131, 911920.CrossRefGoogle ScholarPubMed
Mattos, A. C. A., Kusel, J. R., Pimenta, P. F. P. and Coelho, P. M. Z. (2006). Activity of praziquantel on in vitro transformed Schistosoma mansoni sporocysts. Memorias do Instituto Oswaldo Cruz 101 (Suppl.1), 283287.CrossRefGoogle ScholarPubMed
McCallum, K. L., Schoenhals, G., Laakso, B., Clarke, B. and Whitfield, C. (1989). A high-molecular-weight fraction of smooth lipopolysaccharide in Klebsiella serotype O1:K20 contains a unique O-antigen epitope and determines resistance to nonspecific serum killing. Infection and Immunity 57, 38163822.CrossRefGoogle ScholarPubMed
McKerrow, J. J. (2003). Invasion of skin by schistosome cercariae:some neglected facts. Trends in Parasitology 19, 6668.CrossRefGoogle Scholar
McGonigle, S., Beall, M. J., Feeney, E. L. and Pearce, E. J. (2001). Conserved role for 14-3-3 epsilon downstream of type I TGFbeta receptors. FEBS Letters 490, 6569.CrossRefGoogle Scholar
McIntosh, R. S., Jones, F. M., Dunne, D. W., McKerrow, J. H. and Pleass, R. J. (2006). Characterization of immunoglobulin binding by schistosomes. Parasite Immunology 28, 407419.CrossRefGoogle ScholarPubMed
McLaren, D. J. (1980). Schistosoma mansoni: the Parasite Surface in Relation to Host Immunity. Research Studies Press, John Wiley and Sons Ltd, Chichester, UK.Google Scholar
McLaren, D. J. and Terry, R. J. (1982). The protective role of acquired host antigens during schistosome maturation. Parasite Immunology 4, 129148.CrossRefGoogle ScholarPubMed
Mecozzi, B., Rossi, A., Lazzaretti, P., Kady, M., Kaiser, S., Valle, C., Cioli, D. and Klinkert, M.-Q. (2000). Molecular cloning of Schistosoma mansoni calcineurin subunits and immunolocalisation to the excretory system. Molecular and Biochemical Parasitology 110, 333343.CrossRefGoogle Scholar
Mendonca-Silva, D. L., Novozhilova, E., Cobbett, P. J. R., Silva, C. L. M., Totten, M. I. J., Maule, A. G. and Day, T. A. (2006). Role of calcium influx through voltage-operated calcium channels and of calcium mobilisation in the physiology of Schistosoma mansoni muscle contractions. Parasitology 133, 6774.CrossRefGoogle ScholarPubMed
Meyer, S., van Liempt, E., Imberty, A., van Kooyk, Y., Geyer, H., Geyer, R. and van Die, I. (2005). DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGN. Journal of Biological Chemistry 280, 3734937359.CrossRefGoogle ScholarPubMed
Mitchell, G. F., Tiu, W. and Garcia, E. G. (1991). Infection characteristics of Schistosoma japonicum in mice and relevance to the assessment of schistosome vaccines. Advances in Parasitology 30, 167200.CrossRefGoogle Scholar
Modha, J. and Doenhoff, M. J. (1994). Schistosoma mansoni host parasite relationship: interaction of contrapsin with adult worms. Parasitology 109, 487495.CrossRefGoogle ScholarPubMed
Modha, J., Lambertucci, J. R., Doenhoff, M. J. and McLaren, D. J. (1990). Immune dependence of schistosomicidal chemotherapy: an ultrastructural study of Schistosoma mansoni adult worms exposed to praziquantel and immune serum in vivo. Parasite Immunology 12, 321334.CrossRefGoogle ScholarPubMed
Moffat, D. and Kusel, J. R. (1992). Fluorescent lipid uptake and transport in adult Schistosoma mansoni. Parasitology 105, 8189.CrossRefGoogle ScholarPubMed
Mone, H. and Boissier, J. (2004). Sexual biology of schistosomes. Advances in Parasitology 57, 89189.CrossRefGoogle ScholarPubMed
Morris, R., Cox, H., Mombelli, E. and Quinn, P. J. (2004). Rafts, little caves and large potholes: how lipid structures interact with membrane proteins to create functionally diverse membrane environments. Subcellular Biochemistry 37, 35118.CrossRefGoogle ScholarPubMed
Mountford, A. P., Harrop, R. and Wilson, R. A. (1995). Antigens derived from lung-stage larvae of Schistosoma mansoni are efficient stimulators of proliferation and gamma interferon secretion by lymphocytes from mice vaccinated with attenuated larvae. Infection and Immunity 63, 19801986.CrossRefGoogle ScholarPubMed
Mountford, A. P. and Trottein, F. (2004). Schistosomes in the skin: a balance between immune priming and regulation. Trends in Parasitology 20, 221226.CrossRefGoogle ScholarPubMed
Muller, G., Dearey, E. A., Korndorfer, A. and Bandlow, W. (1994). Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport. The Journal of Cell Biology 126, 12671276.CrossRefGoogle ScholarPubMed
Murare, H. M., Agnew, A., Baltz, M., Lucas, S. B. and Doenhoff, M. J. (1987). The response to Schistosoma bovis in normal and T-cell deprived mice. Parasitology 95, 517530.CrossRefGoogle ScholarPubMed
Murare, H. M. and Doenhoff, M. J. (1987). Parasitological observations of Schistosoma bovis in normal and T-cell deprived mice. Parasitology 95, 507516.CrossRefGoogle ScholarPubMed
Ngaiza, J. R. and Doenhoff, M. J. (1987). Schistosoma mansoni-induced thrombocytopenia in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 655656.CrossRefGoogle ScholarPubMed
Ngaiza, J. R. and Doenhoff, M. J. (1990). Blood platelets and schistosome egg excretion. Proceedings of the Society of Experimental Biology and Medicine 193, 7379.CrossRefGoogle ScholarPubMed
Ngaiza, J. R., Doenhoff, M. J. and Jaffe, E. A. (1993). Schistosoma mansoni egg attachment to cultured human umbilical vein endothelial cells: an in vitro model of an early step of parasite egg excretion. Journal of Infectious Diseases 168, 15761580.CrossRefGoogle Scholar
Nutten, S., Trottein, F., Gounni, A. S., Papin, J. P., Capron, A. and Capron, M. (1997). From allergy to schistosomes: role of Fc receptors and adhesion molecules in eosinophil effector function. Memorias do Instituto Oswaldo Cruz 92 (Suppl. 2), 914.CrossRefGoogle ScholarPubMed
Nuttman, C. J. (1971). The fine structure of ciliated nerve endings in the cercaria of Schistosoma mansoni. Journal of Parasitology 57, 855859.CrossRefGoogle Scholar
Nyame, A. K., Debose-Boyd, R., Long, T. D., Tsang, V. C. and Cummings, R. D. (1998). Expression of Lex antigen in Schistosoma japonicum and S. haematobium and immune responses to Lex in infected animals: lack of Lex expression in other trematodes and nematodes. Glycobiology 8, 615624.CrossRefGoogle ScholarPubMed
Nyame, A. K., Lewis, F. A., Doughty, B. L., Correa-Oliveira, R. and Cummings, R. D. (2003). Immunity to schistosomiasis: glycans are potential antigenic targets for immune intervention. Experimental Parasitology 104, 113.CrossRefGoogle ScholarPubMed
O'Hagan, R., Chalfie, M. and Goodman, M. B. (2005). The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nature Neuroscience 8, 4350.CrossRefGoogle ScholarPubMed
Okano, M., Satoskar, A. R., Nishizaki, K., Abe, M. and Harn, D. A. (1999). Induction of Th2 responses and IgE is largely due to carbohydrates functioning as adjuvants on Schistosoma mansoni egg antigens. Journal of Immunology 163, 67126717.CrossRefGoogle ScholarPubMed
Okano, M., Satoskar, A. R., Nishizaki, K. and Harn, D. A. Jr. (2001). Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. Journal of Immunology 167, 442450.CrossRefGoogle ScholarPubMed
Oliveira, F., Kusel, J. R., Ribeiro, F. and Coelho, P. M. Z. (2006). Responses of the surface membrane and excretory system of Schistosoma mansoni to damage and to treatment with praziquantel and other biomolecules. Parasitology 132, 321330.CrossRefGoogle ScholarPubMed
Oliveira, G., Rodrigues, N. B., Romanha, A. J. and Bahia, D. (2004). Genome and genomics of schistosomes. Canadian Journal of Zoology-Revue Canadienne de Zoologie 82, 375390.CrossRefGoogle Scholar
Olsen, D. P., Phu, D., Libby, L. J., Cormier, J. A., Montez, K. M., Ryder, E. F. and Politz, S. M. (2007). Chemosensory control of surface antigen switching in the nematode Caenorhabditis elegans. Genes Brain Behaviour 6, 240252.CrossRefGoogle ScholarPubMed
Osman, A., Niles, E. G., Verjovski-Almeida, S. and LoVerde, P. T. (2006). Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene. Public Library of Science, Pathogens 2, e54.Google ScholarPubMed
Papanikolaou, A., Papafotika, A., Murphy, C., Papamarcaki, T., Tsolas, O., Drab, M., Kurzchalia, T. V., Kaspar, M. and Christophoridis, S. (2005). Cholesterol-dependent lipid assemblies regulate the activities of the ectonucleotidase CD39. Journal of Biological Chemistry 280, 2640626414.CrossRefGoogle Scholar
Patton, E. A., Brunet, L. R., La Flamme, A. C., Pedras-Vasconcelos, J., Kopf, M. and Pearce, E. J. (2001). Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent. Infection and Immunity 69, 589592.CrossRefGoogle ScholarPubMed
Pax, R. A. and Bennett, J. L. (1990). Studies on intrategumental pH and its regulation in adult male Schistosoma mansoni. Parasitology 101, 219226.CrossRefGoogle ScholarPubMed
Pearce, E. J., Zilberstein, D., James, S. L. and Sher, A. (1986). Kinetic correlation of the acquisition of resistance to immune attack in schistosomula of Schistosoma mansoni with a developmental change in membrane potential. Molecular and Biochemical Parasitology 21, 259267.CrossRefGoogle ScholarPubMed
Peerce, B. E., Fleming, R. Y. and Clarke, R. D. (2003). Inhibition of human intestinal brush border membrane vesicle Na+-dependent phosphate uptake by phosphophloretin derivatives. Biochemical and Biophysical Research Communications 31, 812.CrossRefGoogle Scholar
Penna, F. J. and Brasileiro, F. G. (1988). Lack of correlation between jejunal mucosal morphology and intestinal absorption in the hepatosplenic form of schistosomiasis mansoni. Arquivos de Gastroenterologia 25, 224228.Google ScholarPubMed
Perez, H. and Terry, R. J. (1973). The killing of adult Schistosoma mansoni in vitro in the presence of antisera to host antigenic determinants and peritoneal cells. International Journal for Parasitology 3, 499503.CrossRefGoogle ScholarPubMed
Perona-Wright, G., Jenkins, S. J. and MacDonald, A. S. (2006). Dendritic cell activation and function in response to Schistosoma mansoni. International Journal for Parasitology 36, 711721.CrossRefGoogle ScholarPubMed
Pica-Mattoccia, L., Valle, C., Basso, A., Troiani, A. R., Vigorosi, F., Liberti, P., Festucci, A. and Cioli, D. (2007). Cytochalasin D abolishes the schistosomicidal activity of praziquantel. Experimental Parasitology 115, 344351.CrossRefGoogle ScholarPubMed
Pike, L. J. (2004). Lipid rafts: heterogeneity on the high seas. The Biochemical Journal 378, 281292.CrossRefGoogle ScholarPubMed
Pike, L. J. and Casey, L. (2002). Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking. Biochemistry 41, 1031510322.CrossRefGoogle ScholarPubMed
Platts, S. H. and Duling, B. R. (2003). Adenosine A3 receptor activation modulates the capillary endothelial glycocalyx. Proceedings of the National Academy of Sciences, USA 100, 79887995.Google Scholar
Pleass, R. J., Kusel, J. R. and Woof, J. M. (2000). Cleavage of human IgE mediated by Schistosoma mansoni. International Archives of Allergy and Immunology 121, 194204.CrossRefGoogle ScholarPubMed
Popiel, I., Irving, D. L. and Basch, P. F. (1985). Wound healing in the trematode Schistosoma. Tissue Cell 17, 6977.CrossRefGoogle ScholarPubMed
Popovici, C., Isnardon, D., Birnbaum, D. and Roubin, R. (2002). Caenorhabditis elegans receptors related to mammalian vascular endothelial growth factor receptors are expressed in neural cells. Neuroscience Letters 329, 116120.CrossRefGoogle ScholarPubMed
Racoosin, E. L., Davies, S. J. and Pearce, E. J. (1999). Caveolae-like structures in the surface membrane of Schistosoma mansoni. Molecular and Biochemical Parasitology 104, 285297.CrossRefGoogle ScholarPubMed
Ramachandran, H., Skelly, P. J. and Shoemaker, C. B. (1996). The Schistosoma mansoni epidermal growth factor receptor homologue, SER, has tyrosine kinase activity and is localized in adult muscle. Molecular and Biochemical Parasitology 83, 110.CrossRefGoogle ScholarPubMed
Rao, K. V. and Ramaswamy, K. (2000). Cloning and expression of a gene encoding Sm 16, an anti inflammatory protein from Schistosoma mansoni. Molecular and Biochemical Parasitology 30, 101108.CrossRefGoogle Scholar
Reddy, A., Caler, E. V. and Andrews, N. W. (2001). Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell 106, 157169.CrossRefGoogle ScholarPubMed
Redman, C. A., Kennington, S., Spathopoulou, T. and Kusel, J. R. (1997). Interconversion of sphingomyelin and ceramide in adult Schistosoma mansoni. Molecular and Biochemical Parasitology 90, 145153.CrossRefGoogle ScholarPubMed
Redman, C. A. and Kusel, J. R. (1996). Distribution and biophysical properties of fluorescent lipids on the surface of adult Schistosoma mansoni. Parasitology 113, 137143.CrossRefGoogle ScholarPubMed
Remoortere, A., Hokke, C. H., van Dam, G. J., van Die, I., Deelder, A. M. and van den Eijinden, D. H. (2000). Various stages of schistosoma express Lewis(x), LacdiNAc, GalNAcbeta1-4 (Fucalpha1-3)GlcNAc and GalNAcbeta1-4(Fucalpha1-2Fucalpha1-3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins. Glycobiology 10, 601609.CrossRefGoogle Scholar
Rezende, S. A., Silvateixeira, D. N., Drummond, S. C. and Goes, A. M. (1997). IL-10 plays a role in the modulation of human granulomatous hypersensitivity against Schistosoma mansoni eggs induced by immune complexes. Scandinavian Journal of Immunology 46, 96102.CrossRefGoogle Scholar
Ribeiro, F., Coelho, P. M. Z., Vieira, L. Q., Powell, K. and Kusel, J. R. (1998). Membrane internalization processes in different stages of Schistosoma mansoni as shown by a styryl dye (Frei Mao 1-43). Parasitology 116, 5159.CrossRefGoogle ScholarPubMed
Riengrojpitak, S., Vojvodic, M., Boot, C. and Wilson, R. A. (1989). Reactivity of anti-tegument monoclonal antibodies with target epitopes in different worm tissues and developmental stages of Schistosoma mansoni. Parasitology 98, 213225.CrossRefGoogle ScholarPubMed
Roberts, S. M., MacGregor, A. N., Vojvodic, M., Wells, E., Crabtree, J. E. and Wilson, R. A. (1983). Tegument surface membrane of adult Schistosoma mansoni: development of a method for their isolation. Molecular and Biochemical Parasitology 9, 105127.CrossRefGoogle ScholarPubMed
Robertson, A., Kusel, J. R. and Martin, R. J. (1997). A vesicle preparation for resolving single-channel currents in tegument of male Schistosoma mansoni. Parasitology 115, 183192.CrossRefGoogle ScholarPubMed
Robertson, N. P. and Cain, G. D. (1985). Isolation and characterization of glycosaminoglycans from Schistosoma mansoni. Comparative Biochemistry and Physiology B 82, 299306.CrossRefGoogle ScholarPubMed
Robijn, M. L., Wuhrer, M., Kornelis, D., Deelder, A. M., Geyer, R. and Hokke, C. H. (2005). Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs. Parasitology 130, 6777.CrossRefGoogle ScholarPubMed
Rocha, M. O. and Coelho, P. M. Z. (1980). The importance of skin and pulmonary phases to the development of Schistosoma mansoni in albino mice. Revista Instituto de Medicina Tropical de Sao Paulo 22, 157163.Google Scholar
Roepstorff, K., Thomsen, P., Sandvig, K. and van Deurs, B. (2002). Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding. Journal of Biological Chemistry 277, 1895418960.CrossRefGoogle ScholarPubMed
Rook, G. A. W. and Stanford, J. L. (1998). Give us this day our daily germs. Immunology Today 19, 113116.CrossRefGoogle ScholarPubMed
Roth, A. F. and Davis, N. G. (1996). Ubiquitination of the yeast a-factor receptor. The Journal of Cell Biology 134, 661674.CrossRefGoogle ScholarPubMed
Rudnicka, W., Czkwianianc, E., Planeta-Malecka, I., Jurkiewicz, M., Wisniewska, M., Cieslikowski, T., Rozalska, B., Wadstrom, T. and Chmiela, M. (2001). A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases. FEMS Immunological and Medical Microbiology 30, 121125.CrossRefGoogle ScholarPubMed
Rumjanek, F. D. (1987). Biochemistry and physiology. In Biology of Schistosomes, from Genes to Latrines (ed. Rollinson, D. and Simpson, A. J. G.), pp. 163183. Academic Press, London.Google Scholar
Ruppel, A., Rother, U., Vongerichten, H. and Diesfeld, H. J. (1983). Schistosoma mansoni: complement activation in human and rodent sera by living parasites of various developmental stages. Parasitology 87, 7586.CrossRefGoogle ScholarPubMed
Rutitzky, L. I., Hernandez, H. J. and Stadecker, M. J. (2001). Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection. Proceedings of the National Academy of Sciences, USA 98, 1324313248.CrossRefGoogle ScholarPubMed
Ryan, U. S. and Ryan, J. W. (1984). The ultrastructural basis of endothelial cell surface functions. Biorheology 21, 5570.Google ScholarPubMed
Saad, A. A., O'Connor, P. J., Mostafa, M. H., Metwalli, N. E., Cooper, D. P., Margison, G. P. and Povey, A. C. (2006). Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium. Cancer Epidemiological Biomarkers Preview 15, 740743.CrossRefGoogle ScholarPubMed
Sabin, E. A. and Pearce, E. J. (1995). Early IL-4 production by non-CD4(+) cells at the site of antigen deposition predicts the development of a T-helper-2 cell response to Schistosoma mansoni eggs. Journal of Immunology 155, 48444853.CrossRefGoogle ScholarPubMed
Salo, E. and Barguna, J. (1986). Stimulation of cellular proliferation and differentiation in the intact and regenerating planarian Dugresia tigrina by the neuropeptide substance P. Journal of Experimental Biology 237, 129135.Google ScholarPubMed
Salzet, M., Capron, A. and Stefano, G. B. (2000). Molecular crosstalk in host-parasite relationships: schistosome- and leech-host interactions. Parasitology Today 16, 536540.CrossRefGoogle ScholarPubMed
Sanchez, A. A. (2006). Planarian regeneration: its end is its beginning. Cell 124, 241245.CrossRefGoogle Scholar
Sands, W. and Kusel, J. R. (1992). Changes in the lateral diffusion of fluorescent lipid analogues in the surface membrane of adult male Schistosoma mansoni. Molecular and Biochemical Parasitology 53, 233239.CrossRefGoogle ScholarPubMed
Sato, H., Kusel, J. R. and Thornhill, J. A. (2002). Functional visualisation of the excretory system of adult Schistosoma mansoni by the fluorescent marker resorufin. Parasitology 125, 527535.CrossRefGoogle ScholarPubMed
Sato, H., Kusel, J. R. and Thornhill, J. A. (2004). Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system. Parasitology 128, 4355.CrossRefGoogle ScholarPubMed
Saule, P., Vicogne, J., Delacre, M., Macia, L., Tailleux, A., Dissous, C., Auriault, C. and Wolowczuk, I. (2005). Host glucose metabolism mediates T4 and IL-7 action on Schistosoma mansoni development. Journal of Parasitology 91, 737744.CrossRefGoogle ScholarPubMed
Sauma, S. Y., Tanaka, T. M. and Strand, M. (1991). Selective release of a glycosylphosphatidylinositol-anchored antigen from the surface of Schistosoma mansoni. Molecular and Biochemical Parasitology 46, 7380.CrossRefGoogle ScholarPubMed
Saunders, N., Wilson, R. A. and Coulson, P. S. (1987). The outer bilayer of the adult schistosome tegument has a low turnover rate in vitro and in vivo. Molecular and Biochemical Parasitology 25, 123131.CrossRefGoogle Scholar
Schechtman, D., Winnen, R., Tarrab-Hazdai, R., Ram, D., Schinder, V., Grevelding, C. G., Kunz, W. and Arnon, R. (2001). Expression and immunolocalization of the 14-3-3 protein of Schistosoma mansoni. Parasitology 123, 573582.CrossRefGoogle ScholarPubMed
Schmidt, J. (1995). Glycans with N-acetyllactosamine-like residues covering adult Schistosoma mansoni and glycomimesis as a putative mechanism of immune evasion. Parasitology 111, 325336.CrossRefGoogle ScholarPubMed
Schramm, G., Falcone, F. H., Gronow, A., Haisch, K., Mamat, U., Doenhoff, M. J., Oliveira, G., Galle, J., Dahinden, C. A. and Haas, H. (2003). Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs. Journal of Biological Chemistry 278, 1838418392.CrossRefGoogle ScholarPubMed
Schramm, G., Gronow, A., Knobloch, J., Wippersteg, V., Grevelding, C. G., Galle, J., Fuller, H., Stanley, R. G., Chiodini, P. L., Haas, H. and Doenhoff, M. J. (2006). IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 147, 919.CrossRefGoogle Scholar
Schussler, P., Grevelding, C. G. and Kunz, W. (1997). Identification of Ras, MAP kinases and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male-female interaction. Parasitology 115, 629634.CrossRefGoogle Scholar
Shaker, Y. M., Wu, C. H., El-Shobaki, F. A., Ashour, E., Khattab, H. M., Draz, H. M., Kamel, R. and Wu, G. Y. (1998). Human portal serum stimulates cell proliferation in immature Schistosoma mansoni. Parasitology 177, 293299.CrossRefGoogle Scholar
Shaw, J. R., Marshall, I. and Erasmus, D. A. (1977). Schistosoma mansoni: in vitro stimulation of vitelline cell development by extracts of male worms. Experimental Parasitology 42, 1420.CrossRefGoogle ScholarPubMed
Sherman, L. A. and Lara, A. M. (1989). Unrestricted recognition of a nonpeptide antigen by CD8+ cytolytic T lymphocytes. Journal of Immunology 143, 34443447.CrossRefGoogle ScholarPubMed
Shi, Y., Evans, J. E. and Rock, K. L. (2003). Molecular identification of a danger signal that alerts the immune system to dying cells. Nature, London 425, 516521.CrossRefGoogle ScholarPubMed
Siddiqui, A. A., Phillips, T., Charest, H., Podesta, R. B., Quinlin, M. L., Pinkson, J. R., Lloyd, J. D., Paz, M., Villalovos, R. M. and Pompa, J. (2003 a). Induction of protective immunity against Schistosoma mansoni with the large sub-unit of calpain. Infection and Immunity 71, 38443851.CrossRefGoogle Scholar
Siddiqui, A. A., Phillips, T., Charest, H., Podesta, R. B., Quinlin, M. L., Pinkson, J. R., Lloyd, J. D., Pompa, J., Villalovos, R. M. and Paz, M. (2003 b). Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation. Vaccine 21, 28822889.CrossRefGoogle Scholar
Siddiqui, A. A., Zhou, Y., Podesta, R. B., Karcz, S. R., Tognon, C. E., Strejan, G. H., Dekaban, G. A. and Clarke, M. W. (1993). Characterisation of a Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni. Biochimica et Biophysica Acta 1181, 3744.CrossRefGoogle Scholar
Siegel, D. A. and Tracy, J. W. (1988). Effect of pairing in vitro on the glutathione level of male Schistosoma mansoni. Journal of Parasitology 74, 524531.CrossRefGoogle ScholarPubMed
Siegel, D. A. and Tracy, J. W. (1989). Schistosoma mansoni: influence of the female parasite on glutathione biosynthesis in the male. Experimental Parasitology 69, 116124.CrossRefGoogle ScholarPubMed
Silva, C., Lenzi, H., Silva, V., Paulo, F. and Noel, F. (2004). Cellular mechanisms involved in the increased contraction of the portal vein from Schistosoma mansoni infected mice. Parasitology Research 89, 1622.Google Scholar
Simon, S. M., Blobel, G. and Zimmerberg, J. (1989). Large aqueous channels in membrane vesicles derived from the rough endoplasmic reticulum of canine pancreas or the plasma membrane of Escherichia coli. Proceedings of the National Academy of Sciences, USA 86, 61766180.CrossRefGoogle ScholarPubMed
Simons, K. and Ikonen, E. (1997). Functional rafts in cell membranes. Nature, London 387, 569572.CrossRefGoogle ScholarPubMed
Singer, S. J. and Nicolson, G. L. (1972). The fluid mosaic model of the structure of cell membranes. Science 175, 720731.CrossRefGoogle ScholarPubMed
Singleton, P. A. and Bourguignon, L. Y. (2004). CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation. Experimental Cell Research 295, 102118.CrossRefGoogle ScholarPubMed
Skelly, P. (2005). The surface of schistosomes in the vertebrate host. In Schistosomiasis: World Class Parasites, Vol. 10 (ed. Secor, W. E. and Colley, D. G.), pp. 81100. Springer, New York.CrossRefGoogle Scholar
Skelly, P. J. (2004). Intravascular schistosomes and complement. Trends in Parasitology 20, 370374.CrossRefGoogle ScholarPubMed
Skelly, P. J., Da'dara, A. and Harn, D. A. (2003). Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference. International Journal for Parasitology 33, 363369.CrossRefGoogle ScholarPubMed
Skelly, P. J., Pfeiffer, R., Verrey, F. and Shoemaker, C. B. (1999). SPRM1lc, a heterodimeric amino acid permease light chain of the human parasitic platyhelminth, Schistosoma mansoni. Parasitology 119, 569576.CrossRefGoogle ScholarPubMed
Skelly, P. and Shoemaker, C. (2001 a). The Schistosoma mansoni host-interactive tegument forms from vesicle irruptions of a cyton network. Parasitology 122, 6773.CrossRefGoogle Scholar
Skelly, P. J. and Shoemaker, C. B. (1996). Rapid appearance and asymmetric distribution of glucose transporter SGTP4 at the apical surface of intramammalian-stage Schistosoma mansoni. Proceedings of the National Academy of Sciences, USA 93, 36423646.CrossRefGoogle ScholarPubMed
Skelly, P. J. and Shoemaker, C. B. (2001 b). Schistosoma mansoni proteases Sm31 (cathepsin B) and Sm32 (legumain) are expressed in the caecum and protonephridia of cercariae. Journal of Parasitology 87, 12181221.CrossRefGoogle ScholarPubMed
Skelly, P. J. and Wilson, R. A. (2006). Making sense of the schistosome tegument. Advances in Parasitology 63, 185284.CrossRefGoogle Scholar
Smart, D., Johnston, C. F., Maule, A. G., Halton, D. W., Hrckova, G., Shaw, C. and Buchanan, K. D. (1995). Localization of Diploptera punctata allatostatin-like immunoreactivity in helminths: an immunocytochemical study. Parasitology 110, 8796.CrossRefGoogle ScholarPubMed
Smith, H. V. and Kusel, J. R. (1979). The acquisition of antigens in the intercellular substance of mouse skin by schistosomula of Schistosoma mansoni. Clinical and Experimental Immunology 36, 430435.Google ScholarPubMed
Smithers, S. R., Terry, R. J. and Hockley, D. J. (1969). Host antigens in Schistosomiasis. Proceedings of the Royal Society of London, B 171, 483494.Google ScholarPubMed
Smyth, D. J., Glanfield, A., McManus, D. P., Hacker, E., Blair, D., Anderson, G. J. and Jones, M. K. (2006). Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes. Journal of Biological Chemistry 281, 22422248.CrossRefGoogle ScholarPubMed
Snary, D., Smith, M. A. and Clegg, J. A. (1980). Surface proteins of Schistosoma mansoni and their expression during morphogenesis. European Journal of Immunology 10, 573575.CrossRefGoogle ScholarPubMed
Stadecker, M. J., Asahi, H., Finger, E., Hernandez, H. J., Rutitzky, L. I. and Sun, J. (2004). The immunobiology of Th1 polarization in high-pathology schistosomiasis. Immunological Reviews 201, 168179.CrossRefGoogle ScholarPubMed
Stanley, R. G., Ngaiza, J. R., Atieno, E., Jell, G., Francklow, K., Jackson, C. L., Parry, H. and Doenhoff, M. J. (2003 a). Immune-dependent thrombocytopaenia in mice infected with Schistosoma mansoni. Parasitology 126, 225229.CrossRefGoogle ScholarPubMed
Stanley, R. G., Ngaiza, J. R., Wambayi, E., Lewis, J. and Doenhoff, M. J. (2003 b). Platelets as an innate defence mechanism against Schistosoma mansoni infections in mice. Parasite Immunology 25, 467473.CrossRefGoogle ScholarPubMed
Starich, T. A., Herman, R. K., Kari, C. K., Yeh, W. H., Schackwitz, W. S., Schuyler, M. W., Collet, J., Thomas, J. H. and Riddle, D. L. (1995). Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Genetics 139, 171188.CrossRefGoogle ScholarPubMed
Stavrovskaya, A. A. (2000). Cellular mechanisms of multidrug resistance of tumor cells. Biochemistry 65, 95106.Google ScholarPubMed
Steinhardt, R. A., Bi, G. and Alderton, J. M. (1994). Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release. Science 263, 390393.CrossRefGoogle ScholarPubMed
Stirewalt, M. A. (1974). Schistosoma: cercaria to schistosomule. Advances in Parasitology 12, 115182.CrossRefGoogle ScholarPubMed
Stocks, S. C., Albrechtsen, M. and Kerr, M. A. (1990). Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyl-lactosamine, LeX) on putative neutrophil adhesion molecules CR3 and NCA-160. The Biochemical Journal 268, 275280.CrossRefGoogle ScholarPubMed
Strachan, D. P. (1989). Hay-fever, hygiene, and household size. British Medical Journal 299, 12591260.CrossRefGoogle ScholarPubMed
Sukai, M. and Piquette-Miller, M. (2000). Regulation of multidrug resistance genes by stress signals. Journal of Pharmacological Pharmaceutics 3, 268280.Google Scholar
Summers, R. W., Elliott, D. E., Urban, J. F. Jr., Thompson, R. A. and Weinstock, J. V. (2005 a). Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology 128, 825832.CrossRefGoogle ScholarPubMed
Summers, R. W., Elliott, D. E., Urban, J. F., Thompson, R. and Weinstock, J. V. (2005 b). Trichuris suis therapy in Crohn's disease. Gut 54, 8790.CrossRefGoogle ScholarPubMed
Sun, J., Daniel, R., Wagner-Dobler, I. and Zeng, A. P. (2004). Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways. BMC Evolutionary Biology 4, 36.CrossRefGoogle ScholarPubMed
Suzuki, H., Kerr, R., Bianchi, L., Frokjaer-Jensen, C., Slone, D., Xue, J., Gerstbrein, B., Driscoll, M. and Schafer, W. R. (2003). In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 39, 10051017.CrossRefGoogle ScholarPubMed
Tallima, H. (2006). Biochemical exposure of Schistosoma surface membrane antigens. Ph.D. thesis, University of Cairo, Egypt.Google Scholar
Tallima, H. and El Ridi, R. (2005). Methyl-beta cyclodextrin treatment and filipin staining reveal the role of cholesterol in surface membrane antigen sequestration of Schistosoma mansoni and Schistosoma haematobium lung-stage larvae. Journal of Parasitology 91, 720725.CrossRefGoogle ScholarPubMed
Tallima, H., Salah, M. and El Ridi, R. (2005). In vitro effects of unsaturated fatty acids on Schistosoma mansoni and S. haematobium lung-stage larvae. Journal of Parasitology 91, 10941102.CrossRefGoogle ScholarPubMed
Tan, H. H., Thornhill, J. A., Al-Adhami, B. H., Akhkha, A. and Kusel, J. R. (2003). A study of the effect of surface damage on the uptake of Texas Red BSA by schistosomula of Schistosoma mansoni. Parasitology 126, 235240.CrossRefGoogle ScholarPubMed
Taramelli, D., Recalcati, S., Basilico, N., Olliaro, P. and Cairo, G. (2000). Macrophage preconditioning with synthetic malaria pigment reduces cytokine production via heme iron-dependent oxidative stress. Laboratory Investigation 80, 17811788.CrossRefGoogle ScholarPubMed
Tarrab-Hazdai, R., Camacho, M., Mendelovic, F. and Schechtman, D. (1997). An association between activity of the Na/K-pump and resistance of Schistosoma mansoni towards complement-mediated killing. Parasite Immunology 19, 395400.CrossRefGoogle ScholarPubMed
Tauber, R., Park, C. S., Becker, A., Geyer, R. and Reutter, R. (1989). Rapid intramolecular turnover of N-linked glycans in plasma membrane glycoproteins. Extension of intramolecular turnover to the core sugars in plasma membrane glycoproteins of hepatoma. European Journal of Biochemistry 186, 5562.CrossRefGoogle Scholar
Tavares, C. A. P., Gazzinelli, G., Mota-Santos, T. A. and Dias de Silva, W. (1978). Schistosoma mansoni: complement mediated cytotoxic activity in vitro and effect of decomplentation on aquired immunity in mice. Experimental Parasitology 46, 145151.CrossRefGoogle Scholar
Taylor, D. E., Fedorak, R. N. and Sherburne, R. (1999). Antigenic mimicry between Helicobacter pylori and gastric mucosa: failure to implicate heat-shock protein Hsp60 using immunoelectron microscopy. Helicobacter 4, 148153.CrossRefGoogle ScholarPubMed
Testi, R. (1996). Sphingomyelin breakdown and cell fate. Trends in Biochemical Sciences 21, 468471.CrossRefGoogle ScholarPubMed
Teixeira, M. M., Doenhoff, M. J., McNeice, C., Williams, T. J. and Hellewell, P. G. (1993). Mechanisms of the inflammatory response induced by extracts of Schistosoma mansoni larvae in guinea-pig skin. Journal of Immunology 151, 55255534.CrossRefGoogle ScholarPubMed
Thi, M., Tarbell, J. M., Weinbaum, S. and Spray, D. C. (2004). The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress. Proceedings of the National Academy of Sciences, USA 101, 1648316488.CrossRefGoogle ScholarPubMed
Thomas, P. G. and Harn, D. A. (2004). Immune biasing by helminth glycans. Cellular Microbiology 6, 1322.CrossRefGoogle ScholarPubMed
Thors, C., Jokiranta, T. S., Meri, T., Kairemo, K., Meri, S. and Linder, E. (2006). Immunoglobulin uptake and processing by Schistosoma mansoni. Parasite Immunology 28, 421428.CrossRefGoogle ScholarPubMed
Threadgold, L. T. and Arme, C. (1974). Electron microscope studies of Fasciola hepatica XI: autophagy and parenchymal cell function. Experimental Parasitology 35, 389405.CrossRefGoogle ScholarPubMed
Thundimadathil, J., Roeske, R. W. and Guo, L. (2005). A synthetic peptide forms voltage-gated porin-like ion channels in lipid bilayer membranes. Biochemical and Biophysical Research Communications 330, 585590.CrossRefGoogle ScholarPubMed
Tiu, W. U., Ehl, A., Walker, J. C., Garcia, E. G., Smith, D. B. and Mitchell, G. F. (1986). Resistance of 129/J mice to Schistosoma mansoni infection. Australian Journal of Experimental Biology and Medical Science 64, 345349.CrossRefGoogle ScholarPubMed
Tran, M. H., Pearson, M. S., Bethony, J. M., Smyth, D. J., Jones, M. K., Duke, M., Don, T. A., McManus, D. P., Correa-Oliveira, R. and Loukas, A. (2006). Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nature Medicine 12, 835840.CrossRefGoogle ScholarPubMed
Troost, J., Lindenmaier, H., Haefeli, W. E. and Weiss, J. (2004). Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells. Molecular Pharmacology 66, 13321339.CrossRefGoogle ScholarPubMed
Trottein, F., Descamps, L., Nutten, S., Dehouck, M. P., Angeli, V., Capron, A., Cecchelli, R. and Capron, M. (1999 a). Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype. Infection and Immunity 67, 34033409.CrossRefGoogle ScholarPubMed
Trottein, F., Nutten, S., Angeli, V., Delerive, P., Tessier, E., Capron, A., Staels, B. and Capron, M. (1999 b). Schistosoma mansoni schistosomula reduce E-selectin and VCAM-1 expression in TNFalpha stimulated lung microvascular endothelial cell by interfering with NF-kappa B pathway. European Journal of Immunology 29, 36913701.3.0.CO;2-L>CrossRefGoogle Scholar
Tsang, V. C., Hubbard, W. J. and Damian, R. T. (1977). Coagulation factor XIIa (activated Hageman factor) inhibitor from adult Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene 26, 243247.CrossRefGoogle ScholarPubMed
Tweto, J. and Doyle, D. (1975). Turnover of plasma membrane proteins of hepatoma tissue culture cells. Journal of Biological Chemistry 251, 872882.CrossRefGoogle Scholar
Unruh, T. L., Li, H., Mutch, C. M., Sharia, N., Grigoriou, L., Sanval, R., Brown, C. B. and Deans, J. P. (2005). Cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking. Immunology 116, 223232.CrossRefGoogle ScholarPubMed
Valensin, S., Paccani, S. R., Ulivieri, C., Mercati, D., Pacini, S., Patrussi, L., Hirst, T., Lupetti, P. and Baldari, C. T. (2002). F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts. European Journal of Immunology 32, 435446.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Van Dam, G. J., Bergwerff, A. A., Thomasoates, J. E., Rotmans, J. P., Kamerling, J. P., Vliegenthart, J. F. G. and Deelder, A. M. (1994). The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis-X as repeating unit. European Journal of Biochemistry 225, 467482.CrossRefGoogle ScholarPubMed
Van Dam, G. J., Bogitsh, B. J., Vanzeyl, R. J. M., Rotmans, J. P. and Deelder, A. M. (1996 a). Schistosoma mansoni: in vitro and in vivo excretion of CAA and CCA by developing schistosomula and adult worms. Journal of Parasitology 82, 557564.CrossRefGoogle ScholarPubMed
Van Dam, G. J., Claas, F. H., Yazdanbakhsh, M., Kruize, Y. C., van Keulen, A. C., Ferreira, S. T., Rotmans, J. P. and Deelder, A. M. (1996 b). Schistosoma mansoni excretory circulating cathodic antigen shares Lewis-x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes. Blood 88, 42464251.CrossRefGoogle ScholarPubMed
Van Dam, G. J., Seino, J., Rotmans, J. P., Daha, M. R. and Deelder, A. M. (1993). Schistosoma mansoni circulating anodic antigen but not circulating cathodic antigen interacts with complement component C1q. European Journal of Immunology 23, 28072812.CrossRefGoogle Scholar
Van den Biggelaar, A. H. J., Van Ree, R., Rodrigues, L. C., Lell, B., Deelder, A. M., Kremsner, P. G. and Yazdanbakhsh, M. (2000). Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356, 17231727.CrossRefGoogle ScholarPubMed
Vandenbroucke-Grauls, C. M. and Appelmelk, B. J. (1998). Helicobacter pylori LPS: molecular mimicry with the host and role in autoimmunity. Italian Journal of Gastroenterology and Hepatology 30 (Suppl. 3), S259S260.Google ScholarPubMed
Van der Kleij, D., Latz, E., Browers, J. F., Kruize, Y. C., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., Tielens, A. G. and Yazdanbakhsh, M. (2002). A novel host-parasite lipid cross-talk: schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. Journal of Biological Chemistry 277, 4812248129.CrossRefGoogle ScholarPubMed
Van der Kleij, D. and Yazdanbakhsh, M. (2003). Control of inflammatory diseases by pathogens: lipids and the immune system. European Journal of Immunology 33, 29532963.CrossRefGoogle ScholarPubMed
Van Hellemond, J. J., Retra, K., Brouwers, J. F. H. M., van Balco, Kom B. V. M., Yazdanbacksh, M., Shoemaker, C. B. and Tielens, A. G. M. (2006). Functions of the tegument of schistosomes: clues from the proteome and lipidome. International Journal for Parasitology 36, 691699.CrossRefGoogle ScholarPubMed
Vasconcelos, E. G., Nascimento, P. S., Meirelles, M. N., Verjovski-Almeida, S. J. and Ferreira, S. T. (1993). Characterisation and localisation of an ATP-diphosphohydrolase on the external surface of the tegument of Schistosoma mansoni. Molecular and Biochemical Parasitology 58, 205214.CrossRefGoogle ScholarPubMed
Vella, A. T. and Pearce, E. J. (1992). CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage. Journal of Immunology 148, 22832290.CrossRefGoogle ScholarPubMed
Velupillai, P. and Harn, D. A. (1994). Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets. Proceedings of the National Academy of Sciences, USA 91, 1822.CrossRefGoogle ScholarPubMed
Vengesa, P. B. and Leese, H. J. (1979). Sugar absorption by the mouse small intestine following infection with Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 73, 5560.CrossRefGoogle ScholarPubMed
Verjovski-Almeida, S., DeMarco, R., Martins, E. A. L., Guimarães, P. E. M., Ojopi, E. P. B., Paquola, A. C. M., Piazza, J. P., Nishiyama, M. Y. Jr., Kitajima, J. P., Adamson, R. E., Ashton, P. D., Bonaldo, M. F., Coulson, P. S., Dillon, G. P., Farias, L. P., Gregorio, S. P., Ho, P. L., Leite, R. A., Malaquias, L. C. C., Marques, R. C. P., Miyasato, P. A., Nascimento, A. L. T. O., Ohlweiler, F. P., Reis, E. M., Ribeiro, M. A., , R. G., Stukart, G. C., Soares, M. B., Gargioni, C., Kawano, T., Rodrigues, V., Madeira, A. M. B. N., Wilson, R. A., Menck, C. F. M., Setubal, J. C., Leite, L. C. C. and Dias-Neto, E. (2003). Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni. Nature Genetics 35, 148157.CrossRefGoogle ScholarPubMed
Vicogne, J., Pin, J. P., Lardans, V., Capron, M., Noel, C. and Dissous, C. (2003). An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module. Molecular and Biochemical Parasitology 126, 5162.CrossRefGoogle ScholarPubMed
Vieira, L. Q. and Kusel, J. R. (1991). Schistosoma mansoni and Biomphalaria glabrata share some epitopes; common epitopes are present on early stages of Schistosoma mansoni. Comparative Biochemistry and Physiology B 100, 507516.CrossRefGoogle Scholar
Villalba, M., Bi, K., Rodriguez, F., Tanaka, Y., Schoenberger, S. and Altman, A. (2001). Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. Journal of Cell Biology 155, 331338.CrossRefGoogle ScholarPubMed
Von Lichtenberg, F. (1964). Studies on granuloma formation. III. Antigen sequestration and destruction in the schistosome pseudotubercle. American Journal of Pathology 45, 7594.Google ScholarPubMed
Wang, W., Kirschfink, M. and Ruppel, A. (2006). Schistosoma japonicum and S. mansoni cercariae: different effects of protein in medium, of mechanical stress, and of an intact complement system on in vitro transformation to schistosomula. Parasitology Research 99, 269274.CrossRefGoogle ScholarPubMed
Warren, K. (1975). Hepatosplenic Schistosomiasis mansoni: an immunologic disease. Bulletin of the New York Academy of Medicine 51, 545550.Google ScholarPubMed
Weller, P. F. and Dvorak, A. M. (1994). Lipid bodies: intracellular sites for eicosanoid formation. Journal of Allergy and Clinical Immunology 94, 11511156.CrossRefGoogle ScholarPubMed
Whitfield, P. J., Bartlett, A. Q., Khammo, N., Brain, A. P., Brown, M. B., Marriott, C. and Clothier, R. (2003). Delayed tail loss during the invasion of human skin by schistosome cercariae. Parasitology 126, 135140.CrossRefGoogle ScholarPubMed
Wills-Karp, M., Santeliz, J. and Karp, C. L. (2001). The germless theory of allergic disease: revisiting the hygiene hypothesis. Nature Reviews Immunology 1, 6975.CrossRefGoogle ScholarPubMed
Wilson, B. S., Pfeiffer, J. R. and Oliver, J. M. (2002). FcepsilonRI signaling observed from the inside of the mast cell membrane. Molecular Immunology 38, 12591268.CrossRefGoogle ScholarPubMed
Wilson, B. S., Steinberg, S. L., Liederman, K., Pfeiffer, J. R., Surviladze, Z., Zhang, J., Samelson, L. E., Yang, L. H., Kotula, P. G. and Oliver, J. M. (2004). Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes. Molecular Biology of the Cell 15, 25802592.CrossRefGoogle ScholarPubMed
Wilson, M. S. and Maizels, R. M. (2004). Regulation of allergy and autoimmunity in helminth infection. Clinical Reviews in Allergy and Immunology 26, 3550.CrossRefGoogle ScholarPubMed
Wilson, R. A. (1987). Cercariae to liver worms: development and migration in the mammalian host. In Biology of Schistosomes, from Genes to Latrines (ed. Rollinson, D. and Simpson, A. J. G.), pp. 115141. Academic Press, London.Google Scholar
Wilson, R. A. (1990). Leaky livers, portal shunting and immunity to schistosomes. Parasitology Today 6, 354358.CrossRefGoogle ScholarPubMed
Wilson, R. A. and Barnes, P. E. (1977). The formation and turnover of the membranocalyx on the tegument of Schistosoma mansoni. Parasitology 74, 6171.CrossRefGoogle ScholarPubMed
Wilson, R. A. and Webster, L. A. (1974). Protonephridia. Biological Reviews 49, 127160.CrossRefGoogle ScholarPubMed
Wippersteg, V., Kapp, K., Kunz, W., Jackstadt, W. P., Zahner, H. and Grevelding, C. G. (2002). HSP70-controlled GFP expression in transiently transformed schistosomes. Molecular and Biochemical Parasitology 120, 141150.CrossRefGoogle ScholarPubMed
Wippersteg, V., Ribeiro, F., Liedke, S., Kusel, J. R. and Grevelding, C. G. (2003). The uptake of Texas Red BSA in the excretory system of schistosomes and its colocalisation with ER60 promoter induced GFP in transiently transformed adult males. International Journal for Parasitology 33, 11391143.CrossRefGoogle ScholarPubMed
Wolowczuk, I., Nutten, S., Roye, O., Delacre, M., Capron, M., Murray, R. M., Trottein, F. and Auriault, C. (1999). Infection of mice lacking interleukin-7 (IL-7) reveals an unexpected role for IL-7 in the development of the parasite Schistosoma mansoni. Infection and Immunity 67, 41834190.CrossRefGoogle ScholarPubMed
Wood, L. M. and Bacha, W. J. Jr. (1983). Distribution of eggs and the host response in chickens infected with Austrobilharzia variglandis (Trematoda). Journal of Parasitology 69, 682688.CrossRefGoogle ScholarPubMed
Wuhrer, M., Dennis, R. D., Doenhoff, M. J. and Geyer, R. (2000). A fucose-containing epitope is shared by keyhole limpet haemocyanin and Schistosoma mansoni glycosphingolipids. Molecular and Biochemical Parasitology 110, 237246.CrossRefGoogle ScholarPubMed
Wuhrer, M., Balog, C. I. A., Catalina, M. I., Jones, F. M., Schramm, G. S., Haas, H., Doenhoff, M. J., Dunne, D. W., Deelder, A. M. and Hokke, C. H. (2006 a). IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans. FEBS Journal 273, 22762292.CrossRefGoogle Scholar
Wuhrer, M., Koeleman, C. A., Fitzpatrick, J. M., Hoffmann, K. F., Deelder, A. M. and Hokke, C. H. (2006 b). Gender-specific expression of complex-type N-glycans in schistosomes. Glycobiology 16, 9911006.CrossRefGoogle ScholarPubMed
Wynn, T. A., Thompson, R. W., Cheever, A. W. and Mentink-Kane, M. M. (2004). Immunopathogenesis of schistosomiasis. Immunological Reviews 201, 156167.CrossRefGoogle ScholarPubMed
Yazdanbakhsh, M., Kremsner, P. G. and Van Ree, R. (2002). Immunology: allergy, parasites, and the hygiene hypothesis. Science 296, 490494.CrossRefGoogle ScholarPubMed
Yazdanbakhsh, M. and Matricardi, P. M. (2004). Parasites and the hygiene hypothesis: regulating the immune system? Clinical Review of Allergy and Immunology 26, 1523.CrossRefGoogle ScholarPubMed
Young, B. W. and Podesta, R. B. (1986). Complement and 5-HT increase phosphatidylcholine incorporation into the outer bilayers of Schistosoma mansoni. Journal of Parasitology 72, 802803.CrossRefGoogle ScholarPubMed
Zaccone, P., Fehervari, Z., Jones, F. M., Sidobre, S., Kronenberg, M., Dunne, D. W. and Cooke, A. (2003). Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. European Journal of Immunology 33, 14391449.CrossRefGoogle ScholarPubMed
Zhang, Y., Bickle, Q. D. and Taylor, M. G. (2000). Cloning of Schistosoma japonicum 14-3-3 epsilon (Sj14-3-3 epsilon), a new member of the 14-3-3 family of proteins from schistosomes. International Journal for Parasitology 30, 991994.CrossRefGoogle ScholarPubMed
Zhou, Y. and Podesta, R. B. (1989). Effects of serotonin and complement on the synthesis of the surface membrane precursors of adult Schistosoma mansoni. Journal of Parasitology 75, 333343.CrossRefGoogle ScholarPubMed