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Schistosoma mansoni: a histological study of migration in the laboratory mouse

Published online by Cambridge University Press:  06 April 2009

P.R. Wheater  and
R. A. Wilson
P.R. Wheater
Affiliation:
Department of Pathology, Medical School, University of Nottingham
R. A. Wilson
Affiliation:
Department of Biology, University of York
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Summary

Quantitative histological methods were applied in a study of the migratory route of schistosomula within the definitive mammal host. The observations are consistent with an entirely intravascular mode of migration in the direction of blood flow. They do not support a trans-diaphragm route. Schistosomula can be identified in low numbers in systemic organs, in the left side of the heart and in the venous compartment of the pulmonary circulation. They were not observed penetrating the diaphragm or the capsule of the liver. No histopathological evidence was found to suggest that the tissue responses of previously unexposed hosts affect migrating schistosomula at any stage during migration. These non-specific tissue responses were marked only in the skin phase of migration.

Type
Research Article
Information
Parasitology , Volume 79 , Issue 1 , August 1979 , pp. 49 - 62
Copyright
Copyright © Cambridge University Press 1979

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