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The role of the spleen in relation to natural and acquired immunity to infections of Babesia rodhaini in the rat

Published online by Cambridge University Press:  06 April 2009

R. S. Phillips
R. S. Phillips
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Madingley Road, Cambridge
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Extract

In the system investigated the spleen was essential in most rats for the acquisition of immunity and its maintenance in the presence of the piroplasm.

It is stressed that model immunological systems involving the role of the spleen do not simulate the complexity of a parasitic infection. The roles of the spleen as an antibody producer, and as a site of phagocytosis and haemopoiesis are discussed in relation to the control of Babesia rodhaini by the rat. The possibility that the piroplasm may be able to undergo antigenic variation is considered.

Type
Research Article
Information
Parasitology , Volume 59 , Issue 3 , August 1969 , pp. 637 - 648
Copyright
Copyright © Cambridge University Press 1969

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References

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