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The role of drugs in the control of parasitic nematode infections: must we do without?

Published online by Cambridge University Press:  01 June 1997

M. H. ROOS
M. H. ROOS
Affiliation:
Institute for Animal Science and Health (ID-DLO), Department of Molecular Recognition, P.O. Box, 65, 8200 AB, Lelystad, The Netherlands
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Abstract

Parasitic helminths (worms) cause serious infectious diseases in humans and domestic animals. Control of these infections relies mostly on chemotherapeutics (the anthelmintics), but resistance has developed against most of these broad-spectrum drugs in many parasite species. These resistant parasites are being used to elucidate the molecular mechanisms of drug resistance and drug action. This has led to the development of sensitive assays to detect resistant parasites, but this has not delayed the emergence of additional drug resistant parasite populations. Therefore, as development of new drugs by pharmaceutical companies is slow, we may have to be prepared for a time when broad-spectrum drugs are no longer effective, especially against worms of sheep.

Keywords

drug resistancegenetic resistanceparasitenematodeanthelmintics
Type
Research Article
Information
Parasitology , Volume 114 , Issue 7 , June 1997 , pp. 137 - 144
Copyright
© 1997 Cambridge University Press

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