Hostname: page-component-f554764f5-44mx8 Total loading time: 0 Render date: 2025-04-15T07:54:11.140Z Has data issue: false hasContentIssue false
  • English
  • Français

The release of antigens by Plasmodium falciparum

Published online by Cambridge University Press:  06 April 2009

R. J. M. Wilson  and
R. K. Bartholomew
R. J. M. Wilson
Affiliation:
National Institute for Medical Research, Mill Hill, London NW7 1AA, and MRC Laboratories, Fajara, The Gambia, West Africa
R. K. Bartholomew
Affiliation:
National Institute for Medical Research, Mill Hill, London NW7 1AA, and MRC Laboratories, Fajara, The Gambia, West Africa
Get access Rights & Permissions [Opens in a new window]

Extract

Antigens were released in vitro from human red cells infected with Plasmodium falciparum only when parasites reached a late stage of schizogony (probably at rupture of infected red cells during reinvasion). Immune complexes formed if antibody was present. Serum from immune Aotus monkeys opsonized parasite debris from artificially disrupted infected Aotus red cells.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 2 , October 1975 , pp. 183 - 192
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Brown, K. N. & Brown, I. N. (1965). Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature, London 208, 1286–8.CrossRefGoogle ScholarPubMed
Cohen, S., Butcher, G. A. & Crandall, R. B. (1969). Action of malarial antibody in vitro. Nature, London 223, 368–71.CrossRefGoogle ScholarPubMed
Cooper, N. R. & Fogel, B. J. (1966). Complement in acute experimental malaria II. Alterations in the components of complement. Military Medicine 131, 1180–90.CrossRefGoogle ScholarPubMed
Geiman, Q. M., Siddiqui, W. A. & Schnell, J. V. (1966). Plasma replacement for in vitro culture of Plasmodium knowlesi. Science 153, 1129–30.CrossRefGoogle ScholarPubMed
Houba, V. & Williams, A. I. O. (1972). Soluble serum antigens of P. falciparum in Nigerians. II. Immunochemical studies. African Journal of Medical Science 3, 309–17.Google ScholarPubMed
McGregor, I. A., Hall, P. J., Williams, K., Hardy, C. L. S. & Turner, M. W. (1966). Demonstration of circulating antibodies to Plasmodium falciparum by gel diffusion techniques. Nature, London 210, 1384–6.CrossRefGoogle ScholarPubMed
Mcgregor, I. A., Turner, M. W., Williams, K. & Hall, P. (1968). Soluble antigens in the blood of African patients with severe Plasmodium falciparum malaria. Lancet 1, 881–4.CrossRefGoogle ScholarPubMed
McGregor, I. A. & Wilson, R. J. M. (1971). Precipitating antibodies and immunoglobulins in P. falciparum infections in the Gambia, West Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 65, 136–45.CrossRefGoogle Scholar
Nelson, D. S. (1969). Macrophages and Immunity, pp. 94–137. Amsterdam: North-Holland Publishing Co.Google Scholar
Spitznagel, J. K. & Allison, A. C. (1970). Mode of action of adjuvants: effects on antibody responses to macrophage-associated bovine serum albumin. Journal of Immunology 104, 128–39.CrossRefGoogle ScholarPubMed
Unanue, E. R. (1972). The regulatory role of macrophages in antigenic stimulation. Advances in Immunology 15, 95–165.CrossRefGoogle ScholarPubMed
Voller, A. & Bray, R. S. (1962). Fluorescent antibody staining as a measure of malarial antibody. Proceedings of the Society of Experimental Biology and Medicine 110, 907–10.CrossRefGoogle ScholarPubMed
Wilson, R. J. M. (1974 a). The production of antigens by Plasmodium falciparum in vitro. International Journal of Parasitology 4, 537–47.CrossRefGoogle ScholarPubMed
Wilson, R. J. M. (1974 b). Soluble antigens as blocking antigens. Ciba Foundation Symposium 25 (new series), pp. 185–203. Associated Scientific Publishers: Amsterdam.Google Scholar
Wilson, R. J. M., McGregor, I. A., Hall, P.Williams, K., & Bartholomew, R. (1969). Antigens associated with Plasmodium falciparum infections in man. Lancet 2, 201–5.CrossRefGoogle ScholarPubMed
Wilson, R. J. M., McGregor, I. A. & Wilson, M. E. (1973). The stability and fractionation of malarial antigens from the blood of Africans infected with Plasmodium falciparum. International Journal of Parasitology 3, 511–20.CrossRefGoogle ScholarPubMed
Wilson, R. J. M., McGregor, I. A., Hall, P., Williams, K. & Bartholomew, R. (1975). Precipitating antibody response to malarial S-antigens. Transactions of the Royal Society of Tropical Medicine and Hygiene. (In the Press.)Google Scholar