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The relationship between worm burden and levels of a circulating antigen (CAA) of five species of Schistosoma in mice

Published online by Cambridge University Press:  06 April 2009

A. Agnew ,
A. J. C. Fulford ,
N. De Jonge ,
F. W. Krijger ,
M. Rodriguez-Chacon ,
V. Gutsmann  and
A. M. Deelder
A. Agnew
Affiliation:
Wellcome Centre for Parasitic Infections, Imperial College of Science, Technology and Medicine, London SW7 2BB, UK
A. J. C. Fulford
Affiliation:
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
N. De Jonge
Affiliation:
Laboratory for Parasitology, University of Leiden, Wassenaarseweg 52, Leiden, The Netherlands
F. W. Krijger
Affiliation:
Laboratory for Parasitology, University of Leiden, Wassenaarseweg 52, Leiden, The Netherlands
M. Rodriguez-Chacon
Affiliation:
Wellcome Centre for Parasitic Infections, Imperial College of Science, Technology and Medicine, London SW7 2BB, UK
V. Gutsmann
Affiliation:
Wellcome Centre for Parasitic Infections, Imperial College of Science, Technology and Medicine, London SW7 2BB, UK
A. M. Deelder
Affiliation:
Laboratory for Parasitology, University of Leiden, Wassenaarseweg 52, Leiden, The Netherlands
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Summary

This study examines the ability of an assay which measures the amount of a schistosome specific antigen (CAA) in the host circulation to reliably reflect relative worm burden. Mice were infected with 5 species of schistosome with a range of infection dose. The levels of serum CAA increased during schistosome maturation. In all species tested CAA levels correlated well with adult worm burden once the parasites achieved sexual maturity and remained relatively stable during the establishment of egg production. The amount of CAA produced varied between species but within each species CAA levels were proportional to worm numbers: no density-dependent effects on CAA levels were observed even when mice carried worm burdens that were very large relative to host size. T-cell deprivation of the host had no effect on the CAA/worm burden relationship in either Schistosoma mansoni or S. haematobium infections and the CAA equilibrium was unaltered in intact mice when reduction of worm fecundity occurred. These data support the use of the CAA as an accurate and robust estimate of relative schistosome burden in man.

Keywords

Schistosomacirculating antigenCAAworm burdenfecundity.
Type
Research Article
Information
Parasitology , Volume 111 , Issue 1 , July 1995 , pp. 67 - 76
Copyright
Copyright © Cambridge University Press 1995

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