Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-27T19:20:24.110Z Has data issue: false hasContentIssue false
  • English
  • Français

Reinfection with hookworm after chemotherapy in Papua New Guinea

Published online by Cambridge University Press:  06 April 2009

R. J. Quinnell ,
A. F. G. Slater ,
P. Tighe ,
E. A. Walsh ,
A. E. Keymer  and
D. I. Pritchard
R. J. Quinnell
Affiliation:
Department of Zoology, South Parks Road, Oxford OX1 3PS
A. F. G. Slater
Affiliation:
Department of Zoology, South Parks Road, Oxford OX1 3PS
P. Tighe
Affiliation:
Department of Life Science, Nottingham University, Nottingham NG7 2RD
E. A. Walsh
Affiliation:
Department of Life Science, Nottingham University, Nottingham NG7 2RD
A. E. Keymer
Affiliation:
Department of Zoology, South Parks Road, Oxford OX1 3PS
D. I. Pritchard
Affiliation:
Department of Life Science, Nottingham University, Nottingham NG7 2RD
Get access Rights & Permissions [Opens in a new window]

Summary

Reinfection with hookworm (Necator americanus) following chemotherapy was studied over 2 years in a rural village in Madang Province, Papua New Guinea. The prevalence of hookworm infection had returned to pre-treatment levels after 2 years, and the geometric mean hookworm burden had returned to 58 % of the pre-treatment value. The rate of acquisition of adult worms was independent of host age, and was estimated as a geometric mean of 2·9–3·3 worms/host/year (arithmetic mean 7·9–8·9 worms/host/year). There was significant predisposition to hookworm infection; the strength of this predisposition did not vary significantly between age or sex classes.

Keywords

hookwormNecator americanusreinfectionpredispositionchemotherapyPapua New Guinea
Type
Research Article
Information
Parasitology , Volume 106 , Issue 4 , May 1993 , pp. 379 - 385
Copyright
Copyright © Cambridge University Press 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anderson, R. M. (1986). The population dynamics and epidemiology of intestinal nematode infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 686–96.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1985). Helminth infections of humans: mathematical models, population dynamics and control. Advances in Parasitology 24, 1–101.CrossRefGoogle ScholarPubMed
Anderson, R. M. & Medley, G. F. (1985). Community control of helminth infections of man by mass and selective chemotherapy. Parasitology 90, 629–60.Google Scholar
Anderson, R. M. & Schad, G. A. (1985). Hookworm burdens and faecal egg counts: an analysis of the biological basis of variation. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 812–25.CrossRefGoogle ScholarPubMed
Ashford, R. W. & Barnish, G. (1989). Strongyloides and hookworm in Papua New Guinea: longitudinal studies on treated and untreated children. Annals of Tropical Medicine and Parasitology 83, 583–9.Google Scholar
Ashford, R. W., Hall, A. J. & Babona, D. (1981). Distribution and abundance of intestinal helminths in man in western Papua New Guinea with special reference to Strongyloides. Annals of Tropical Medicine and Parasitology 75, 269–79.Google Scholar
Barnish, G. & Ashford, R. W. (1989 a). Strongyloides cf.fuelleborni in Papua New Guinea: epidemiology in an isolated community, and results of an intervention study. Annals of Tropical Medicine and Parasitology 83, 499–506.Google Scholar
Barnish, G. & Ashford, R. W. (1989 b). Strongyloides cf.fuelleborni and hookworm in Papua New Guinea: patterns of infection within the community. Transactions of the Royal Society of Tropical Medicine and Hygiene 83, 684–8.CrossRefGoogle ScholarPubMed
Bearup, A. J. & Lawrence, J. J. (1950). A parasitological survey of five New Guinea villages. Medical Journal of Australia 1, 724–32.CrossRefGoogle ScholarPubMed
Bradley, M. & Chandiwana, S. K. (1990). Age-dependency in predisposition to hookworm infection in the Burma valley area of Zimbabwe. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 826–8.Google Scholar
Bradley, M., Chandiwana, S. K., Bundy, D. A. P. & Medley, G. F. (1992). The epidemiology and population biology of Necator americanus infection in a rural community in Zimbabwe. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 73–6.Google Scholar
Bundy, D. A. P. (1988). Population ecology of intestinal helminth infections in human communities. Philosophical Transactions of the Royal Society, B 321, 405–20.Google Scholar
Bundy, D. A. P. (1990). Is the hookworm just another geohelminth? In Hookworm Disease: Current Status and New Directions (ed. Schad, G. A. & Warren, K. S.), pp. 147–64. London: Taylor & Francis.Google Scholar
Chandler, A. C. (1929). Hookworm Disease. London: Macmillan.Google Scholar
Elliott, J. M. (1977). Some Methods for the Statistical Analysis of Samples of Benthic Invertebrates. Ambleside, Cumbria: Freshwater Biological Association, Scientific Publication no. 25.Google Scholar
Ettling, J. (1990). The role of the Rockefeller Foundation in hookworm research and control. In Hookworm Disease: Current Status and New Directions (ed. Schad, G. A. & Warren, K. S.), pp. 3–14. London: Taylor & Francis.Google Scholar
Hall, A. (1981). Quantitative variability of nematode egg counts in faeces: a study among rural Kenyans. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 682–7.Google Scholar
Haswell-Elkins, M. R., Elkins, D. B., Manjula, K., Michael, E. & Anderson, R. M. (1988). An investigation of hookworm infection and reinfection following mass anthelminthic treatment in the South Indian fishing community of Vairavankuppam. Parasitology 96, 565–77.Google Scholar
Hill, R. B. (1926). Hookworm reinfestation for three years after treatment in a sanitated area in Porto Rico, and its bearing on permanent hookworm control in the group studied. American Journal of Hygiene 6, 103–17.Google Scholar
Hoagland, K. E. & Schad, G. A. (1978). Necator americanus and Ancylostoma duodenale: life history parameters and epidemiological implications of two sympatric hookworms of humans. Experimental Parasitology 44, 36–49.Google Scholar
Hornabrook, R. W., Kelly, A. & McMillan, B. (1975). Parasitic infection of man on Kar Kar Island, New Guinea. American Journal of Tropical Medicine and Hygiene 24, 590–5.Google Scholar
Jones, H. I. (1976). A study of human helminthiasis on Karkar Island, Madang Province. Papua New Guinea Medical Journal 19, 165–72.Google Scholar
Keymer, A. E. & Pagel, M. (1990). Predisposition to helminth infection. In Hookworm Disease: Current Status and New Directions (ed. Schad, G. A. & Warren, K. S.), pp. 177–209. London: Taylor & Francis.Google Scholar
Pritchard, D. I., Quinnell, R. J., Slater, A. F. G., McKean, P. G., Dale, D. D. S., Raiko, A. & Keymer, A. E.(1990). The epidemiological significance of acquired immunity to Necator americanus: humoral responses to parasite collagen and excretory–secretory antigens. Parasitology 100, 317–26.Google Scholar
Quinnell, R. J. (1992). The population dynamics of Heligmosomoides polygyrus in an enclosure population of wood mice. Journal of Animal Ecology 61, 669–79.CrossRefGoogle Scholar
Schad, G. A. & Anderson, R. M. (1985). Predisposition to hookworm infection in humans. Science 228, 1537–40.Google Scholar
Schad, G. A., Nawalinski, T. A. & Kochar, V. K. (1983). Human ecology and the distribution and abundance of hookworm populations. In Human Ecology and Infectious Disease (ed. Croll, N. A. & Cross, J.), pp.187–223. New York: Academic Press.Google Scholar
Shield, J. M., Vaterlaws, A. L., Kimber, R. J., Payne, R., Casey, G. J., Blunden, R. W. & Kutkaite, D. (1981). The relationship of hookworm infection, anaemia and iron status in a Papua New Guinea highland population and the response to treatment with iron and mebendazole. Papua New Guinea Medical Journal 24, 19–34.Google Scholar
Sokal, R. R. & Rohlf, F. J. (1981). Biometry. SanFrancisco: W. H. Freeman & Co.Google Scholar
Sweet, W. C. (1924). The intestinal parasites of man in Australia and its Dependencies as found by the Australia Hookworm Campaign. Medical Journal of Australia 1, 405–7.Google Scholar
Sweet, W. C. (1925). Hookworm reinfection; an analysis of 8,239 Ceylon egg counts. Ceylon Journal of Science, Section D 1, 129–40.Google Scholar
Vines, A. P. (1970). An epidemiological sample survey of the highlands, mainland and island regions of the territory of Papua New Guinea. M.D. thesis, University of Sydney. Port Moresby: Department of Public Health.Google Scholar
Vines, A. P. & Kelly, A. (1966). Highlands Regional Survey of intestinal parasites. Medical Journal of Australia 2, 635–3.Google Scholar
Zigas, V. (1973). Hookworm anaemia in the Southern Highlands. Papua New Guinea Medical Journal 16, 51–3.Google Scholar