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Radiation-attenuated schistosome vaccination – a brief historical perspective

Published online by Cambridge University Press:  30 March 2009

Q. D. BICKLE
Q. D. BICKLE*
Affiliation:
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
*
*Tel: +0207 927 2609. Fax: 0207 323 5687/636 8739. E-mail: [email protected]
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Summary

The high level of protection which can be induced by vaccination of a range of hosts, from rodents to primates, with live radiation-attenuated schistosome larvae offers great promise for development of a human schistosome vaccine. Studies of the irradiated vaccine models benefitted from significant funding during the 1970–90s and much was learned concerning the inducers, targets and mechanisms of immunity. Less progress was made in definition of the protective antigens involved. The application of new techniques for identifying membrane and secreted antigens has recently provided new vaccine candidates and a new impetus for schistosome vaccine development. This article is intended as an overview of some of the main lessons learned from the studies of the irradiated vaccines as a backdrop to renewed interest in schistosome vaccine development.

Keywords

schistosomiasisradiation attenuationmembrane antigenssecreted antigensvaccine development
Type
Research Article
Information
Parasitology , Volume 136 , Special Issue 12: Special Centenary Issue – Parasitology 1908–2008 , October 2009 , pp. 1621 - 1632
Copyright
Copyright © Cambridge University Press 2009

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