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Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

Published online by Cambridge University Press:  19 November 2009

J. M. BEHNKE*
Affiliation:
School of Biology, University of Nottingham, NottinghamNG7 2RD, UK
D. M. MENGE
Affiliation:
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, Kenya
S. NAGDA
Affiliation:
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, Kenya
H. NOYES
Affiliation:
School of Biological Sciences, University of Liverpool, LiverpoolL69 7ZB, UK
F. A. IRAQI
Affiliation:
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, Kenya
S. J. KEMP
Affiliation:
School of Biological Sciences, University of Liverpool, LiverpoolL69 7ZB, UK
R. J. M. MUGAMBI
Affiliation:
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, Kenya
R. L. BAKER
Affiliation:
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, Kenya
D. WAKELIN
Affiliation:
School of Biology, University of Nottingham, NottinghamNG7 2RD, UK
J. P. GIBSON
Affiliation:
International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi, Kenya
*
*Corresponding author: School of Biology, University of Nottingham, NottinghamNG7 2RD, UK Tel: +44(0)115 951 3208. E-mail [email protected]

Summary

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2009

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