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Programmed cell death in African trypanosomes

Published online by Cambridge University Press:  03 October 2006

S. C. WELBURN ,
E. MACLEOD ,
K. FIGARELLA  and
M. DUZENSKO
S. C. WELBURN
Affiliation:
Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, EH25 9RG
E. MACLEOD
Affiliation:
Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, EH25 9RG
K. FIGARELLA
Affiliation:
Department of Biochemistry, University of Tubingen, Hoppe-Seyler-Str. 4, 72076 Tubingen, Germany
M. DUZENSKO
Affiliation:
Department of Biochemistry, University of Tubingen, Hoppe-Seyler-Str. 4, 72076 Tubingen, Germany
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Abstract

Until recently it had generally been assumed that apoptosis and other forms of programmed cell death evolved during evolution of the metazoans to regulate growth and development in these multicellular organisms. However, recent research is adding strength to the original phenotypic observations described almost a decade ago which indicated that some parasitic protozoa may have evolved a cell death pathway analogous to the process described as apoptosis in metazoa. Here we explore the implications of a programmed cell death pathway in the African tsetse-transmitted trypanosomes.

Keywords

Apoptosisprogrammed cell deathTrypanosoma bruceitrypanosomatids
Type
Research Article
Information
Parasitology , Volume 132 , Supplement S1: Programmed cell death and the protozoan parasite , March 2006 , pp. S7 - S18
Copyright
© 2006 Cambridge University Press

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