Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-29T02:03:38.487Z Has data issue: false hasContentIssue false
  • English
  • Français

Preface: Positive interactions between anti-infection drugs and the immune response: an emerging paradigm

Published online by Cambridge University Press:  06 April 2009

M. J. Doenhoff  and
L. H. Chappell
M. J. Doenhoff
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwnyedd, LL57 2UW, UK
L. H. Chappell
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB9 2TN, Scotland
Get access Rights & Permissions [Opens in a new window]

Summary

In the third and fourth decades of this century chemotherapy began to be established as one of the greatest success stories in medicine. Now unfortunately severe problems compromise the efficacy of drugs used to treat infectious diseases, two of the most serious handicaps being the rapidity with which target pathogens can develop drug-resistance and the slow rate at which replacement products are appearing on the market. Increased understanding of the ways in which existing drugs act may help both to prolong their usefulness and to generate novel therapeutic strategies.

Type
Research Article
Information
Parasitology , Volume 105 , Issue S1: Chemotherapy and the immune system , January 1992 , pp. S1 - S2
Copyright
Copyright © Cambridge University Press 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Badaro, R., Falcoff, E., Badaro, F. S., Carvalho, E. M., Pedral-Sampaio, D., Barrai, A., Carvalho, J. S., Barral-Netto, M., Brandley, M., Silva, L., Bina, J. C., Teixeira, R., Falcoff, R., Rocha, H., Ho, J. L. & Johnson, W. D. (1990). Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. New England Journal of Medicine 322, 16–21.CrossRefGoogle ScholarPubMed
Berger, B. J. & Fairlamb, A. H. (1992). Interactions between immunity and chemotherapy in the treatment of the trypanosomiases and leishmaniases. Parasitology S105, S71–8.CrossRefGoogle Scholar
Buckley, R. H. & Schiff, R. I. (1991). The use of intravenous immunoglobulin in immunodeficiency diseases. New England Journal of Medicine 325, 110–7.Google ScholarPubMed
Carter, R. L., Connors, T. A., Weston, B. J. & Davies, A. J. S. (1973). Treatment of a mouse lymphoma by Lasparaginase: success depends on the host's immune response. International journal of Cancer 11, 345–57.CrossRefGoogle ScholarPubMed
Chappell, L. H. & Wastling, J. M. (1992). Cyclosporin A: antiparasite drug, modulator of the host-parasite relationship and immunosuppressant. Parasitology S105, S25–40.CrossRefGoogle Scholar
Cox, F. E. G. (1992). Interactions between chemotherapy and immunity in bovine theileriosis. Parasitology S105, S79–84.CrossRefGoogle Scholar
Doenhoff, M. J. & Davies, A. J. S. (1992). Hypothesis: impaired immunity as a factor which contributes to the spread of drug-resistance. Parasitology S105, S1O3–5.Google Scholar
Ehrlich, P. (1909). chemotherapie von Infektionskrankheiten. Zeitschrift für arzneimittel Fortbildung 6, 721–33.Google Scholar
Fallon, P. G., Cooper, R. O., Probert, A. J. & Doenhoff, M. J. (1993). Immune-dependent chemotherapy of schistosomiasis. Parasitology S105, S41–8.Google Scholar
Glatt, A. E., Ghirgwin, K. & Landesman, S. H. (1988). Treatment of infrections associated with immunodeficiency virus. New England Journal of Medicine 318, 1439–8.CrossRefGoogle Scholar
Koziel, M. J. & Walker, B. D. (1992). Viruses, chemotherapy and immunity. Parasitology S105, S85–92.CrossRefGoogle Scholar
Maizels, R. M. & Denham, D. A. (1992). Diethylcarbamazine (DEC): immunopharmacological interactions of an antifilarial drug. Parastiology S10S, S49–60.CrossRefGoogle Scholar
Nussler, A. K. & Thomson, A. W. (1992). Immunomodulatory agents in the laboratory and clinic. Parasitology S105, S5–23.CrossRefGoogle Scholar
Osman, A. S., Jennings, F. W. & Holmes, P. H. (1992). The rapid development of drug-resistant Trypanosoma evansi in immunosuppressed mice. Acta Tropica 50, 249–57.CrossRefGoogle ScholarPubMed
Ringoir, S. (1992). The “infection equation”. Infection 20, Suppl. 1, S75–7.CrossRefGoogle Scholar
Stanford, J. L., Bahr, G. M. & Rook, G. A. W. (1990). Immunotherapy with Mycobacterium vaccae as an adjunct to chemotherapy in the treatment of pulmonary tuberculosis. Tubercle 71, 87–93.Google Scholar
Taliaferro, W. H. (1948). The role of the spleen and the lymphoid-macrophage system in the quinine treatment of gallinaceum malaria. Journal of Infectious Diseases 83, 164–80.CrossRefGoogle ScholarPubMed
Targett, G. A. T. (1992). Malaria: drug use and the immune response. Parasitology S105, S61–70.Google Scholar
Zumla, A. & Croft, S. L. (1992). Chemotherapy and immunity in opportunistic parasitic infections in AIDS. Parasitology S105, S93–101.CrossRefGoogle Scholar