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The population dynamics of acquired immunity to Heligmosomoides polygyrus in the laboratory mouse: strain, diet and exposure

Published online by Cambridge University Press:  06 April 2009

A. E. Keymer  and
A. B. Tarlton
A. E. Keymer
Affiliation:
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS
A. B. Tarlton
Affiliation:
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS
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Extract

An experiment was designed to investigate aspects of the population dynamics of acquired immunity to Heligmosomoides polygyrus in laboratory mice. The influence of host strain (CBA or NIH), rate of exposure (5 or 40 L3/mouse/2 weeks) and diet (3 or 16% protein w/w) on the population dynamics of repeated infection and the response to a standard challenge infection were investigated. The time delay between the end of the period of repeated infection and the subsequent challenge (between 1 and 24 weeks) had no effect on worm recovery. The effects of both exposure and diet were significant and similar whether assessed on the basis of the dynamics of repeated infection or response to challenge: low rates of exposure and low dietary protein were both associated with low levels of acquired immunity. Mouse strain was the most important determinant of worm recovery after challenge, but had no significant effect on the degree to which parasite population growth was constrained by acquired immunity during repeated infection. It is suggested that both CBA and NIH mice raise immune responses which act on parasite survival, but that only NIH mice raise responses operative against larval establishment.

Keywords

Heligmosomoides polygyruspopulation dynamicsstraindietimmunity
Type
Research Article
Information
Parasitology , Volume 103 , Issue 1 , August 1991 , pp. 121 - 126
Copyright
Copyright © Cambridge University Press 1991

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References

Anderson, R. M. (1987). The population dynamics and epidemiology of intestinal nematode infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 686–96.CrossRefGoogle Scholar
Anderson, R. M. & May, R. M. (1985). Herd immunity to helminth infection: implications for parasite control. Nature, London 315, 494–6.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Robinson, M. (1985). Genetic control of immunity to Nematospiroides dubius: a 9-day anthelminthic abbreviated immunizing regime that separates weak and strong responder strains of mice. Parasite Immunology 7, 235–53.CrossRefGoogle ScholarPubMed
Berding, C., Keymer, A. E., Murray, J. D. & Slater, A. F. G. (1986). The population dynamics of acquired immunity to helminth infection. Journal of Theoretical Biology 122, 459–71.CrossRefGoogle ScholarPubMed
Berding, C., Keymer, A. E., Murray, J. D. & Slater, A. F. G. (1987). The population dynamics of acquired immunity to helminth infection: experimental and natural transmission. Journal of Theoretical Biology 126, 167–82.CrossRefGoogle ScholarPubMed
Brindley, P. J., He, S., Dobson, C., Pattie, W. A. & Sitepu, P. (1986). Genetic control of resistance to infection with Nematospiroides dubius: segregation of genes influencing parasite population growth. Heredity 57, 53–8.CrossRefGoogle Scholar
Bundy, D. A. P. & Golden, J. (1987). The impact of host nutrition on gastrointestinal helminth populations Parasitology 95, 623–35.CrossRefGoogle ScholarPubMed
Crombie, J. A. & Anderson, R. M. (1985). Population dynamics of Schistosoma mansoni in mice repeatedly exposed to infection. Nature, London 315, 491–3.CrossRefGoogle ScholarPubMed
Crompton, D. W. T., Walters, D. E. & Arnold, S. (1981). Changes in the food intake and body weight of protein-malnourished rats infected with Nippostrongylus brasiliensis (Nematoda). Parasitology 82, 23–38.CrossRefGoogle ScholarPubMed
Keymer, A. E. & Hiorns, R. W. (1986). Heligmosomoides polygyrus (Nematoda): the dynamics of primary and repeated infection in outbred mice. Proceedings of the Royal Society, B 229, 47–67.Google ScholarPubMed
Keymer, A. E. & Slater, A. F. G. (1991). Experimental epidemiology. In Hookworm Disease: Current Status and New Directions (ed. Schad, G. A. and Warren, K. S.). London: Taylor and Francis.Google Scholar
Maema, M. (1987). Dynamics of repeated infections of high and low responder inbred mice with Heligmosomoides polygyrus. Ph.D. thesis, University of London.Google Scholar
Pritchard, D. I., Maizels, R. M., Behnke, J. M. & Appleby, P. (1984). Stage-specific surface antigens of Nematospiroides dubius. Immunology 53, 325–35.Google ScholarPubMed
Slater, A. F. G. & Keymer, A. E. (1988). The influence of protein deficiency on immunity to Heligmosomoides polygyrus (Nematoda) in mice. Parasite Immunology 10, 507–22.CrossRefGoogle ScholarPubMed
Wakelin, D. (1987). Helminth infections. In Genetics of Resistance to Bacterial and Parasitic Infections (ed. Wakelin, D. M. and Blackwell, J. M.). London: Taylor and Francis.Google Scholar