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Polymorphism in Plasmodium vivax MSA1 gene – the result of intragenic recombinations?

Published online by Cambridge University Press:  06 April 2009

Q. Cheng ,
A. Stowers ,
T.-Y. Huang ,
D. Bustos ,
Y.-M. Huang ,
C. Rzepczyk  and
A. Saul
Q. Cheng
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
A. Stowers
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
T.-Y. Huang
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
D. Bustos
Affiliation:
Research Institute for Tropical Medicine, Metro Manila, Philippines
Y.-M. Huang
Affiliation:
Guang Xi Institute of Parasitic Diseases Control, Nanning, GuangXi, People's Republic of China
C. Rzepczyk
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
A. Saul
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
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Summary

The diversity in a 925 bp portion of the Plasmodium vivax MSA1 gene in isolates from the Philippines, China, the Solomon Islands and Papua New Guinea was investigated. A total of 74 base pair changes was found in the amplified fragment from 18 isolates. Most of these changes were single or double base pair substitutions. In several regions, these point changes were tightly linked with one set always present or always absent in the different isolates. Seven such blocks were identified. These blocks were present in different combinations in the different isolates indicating that extensive intragenic recombination has occurred.

Keywords

polymorphismPlasmodium vivaxMSA1PCRsequencerecombination.
Type
Research Article
Information
Parasitology , Volume 106 , Issue 4 , May 1993 , pp. 335 - 345
Copyright
Copyright © Cambridge University Press 1993

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