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Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection

Published online by Cambridge University Press:  06 April 2009

G. H. Mitchell ,
D. A. Johnston ,
B. A. Naylor ,
A. M. Knight  and
N. Wedderburn
G. H. Mitchell
Affiliation:
Department of Immunology, UMDS, The Medical School, Guy's Hospital, London SE1 9RT
D. A. Johnston
Affiliation:
Department of Immunology, UMDS, The Medical School, Guy's Hospital, London SE1 9RT Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
B. A. Naylor
Affiliation:
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
A. M. Knight
Affiliation:
Department of Immunology, UMDS, The Medical School, Guy's Hospital, London SE1 9RT
N. Wedderburn
Affiliation:
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
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Summary

Infection with Plasmodium vivax was established in splenectomized Callithrix jacchus marmosets by inoculation of parasitized blood from Aotus trivirgatus carrying the Vietnam Palo-Alto line of P. vivax. Subsequent blood passage through intact marmosets resulted in higher peak parasitaemias (about 1% of red cells infected) and the loss of stainable Schüffner's dots in infected cells. Primary infections with the adapted line were patent for 74 days or more, and induced both a substantial antibody response, as determined by indirect fluorescence, and some lymphocytosis, but no marked anaemia. Marmosets which had recovered from their primary infection (or in which it was drug-cured) suffered abbreviated patency with low-grade parasitaemia on re-infection.

Type
Research Article
Information
Parasitology , Volume 96 , Issue 2 , April 1988 , pp. 241 - 250
Copyright
Copyright © Cambridge University Press 1988

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